Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology

Pantić, Igor; Cumic, Jelena; Škodrić, Sanja Radojević; Dugalić, Stefan; Brodski, Claude

doi:10.1016/j.cbi.2021.109380

Cited by 22 publications

(16 citation statements)

References 54 publications

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“…In some previous works, it was demonstrated that this compound even in small, sublethal concentrations leads to the reduction of nuclear angular second moment and inverse difference moment (30,31). These changes are probably related to DNA and chromatin damage that takes place due to the effects of reactive oxygen species and oxidative stress as it has been hypothesized recently (34).…”

Section: Fractal Dimension and Textural Features Of Nuclear Chromatinmentioning

confidence: 73%

Application of fractal and textural analysis in medical physiology, pathophysiology and pathology

Pantić¹,

Paunovic²,

Radojević-Škodrić³

2022

Medicinska istraživanja

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Fractal and textural analyses represent a rapidly developing class of computational and mathematical methods with potential wide applications in medicine and biology. In recent years, they have been successfully used for the evaluation of subtle alterations in cell and tissue morphology associated with various physiological and pathological processes. It has been shown that cells in early stages of apoptosis exhibit changes in chromatin fractal and textural features. Cellular senescence is also sometimes associated with changes in textural patterns in some cell populations. So far, artificial intelligence approaches based on co-occurrence matrix textural data were successfully implemented in predicting cell damage in in vitro conditions, with artificial neural networks achieving the best performance. In the future, several methodological issues and challenges related to the use of fractal and textural methods will have to be resolved before their introduction into contemporary clinical practice. This concise review focuses on the recent research on the application of fractal and textural methods in experimental physiology and related fields.

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Section: Fractal Dimension and Textural Features Of Nuclear Chromatinmentioning

confidence: 73%

Application of fractal and textural analysis in medical physiology, pathophysiology and pathology

Pantić¹,

Paunovic²,

Radojević-Škodrić³

2022

Medicinska istraživanja

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“…We have demonstrated that the proapoptotic chemical derivative of dopamine, 6-hydroxydopamine, induces a dose-dependent reduction of chromatin ASM and IDM, while at the same time increasing the values of chromatin GLCM correlation and variance. 6-hydroxydopamine is known for its ability to increase the production of hydrogen peroxide, superoxide anion, and hydroxyl radical in many cell populations, as well as the ability to induce programmed cell death as the consequence of DNA damage (Pantic et al, 2021). Other experiments also suggested that toxins and processes that contribute to ROS generation may increase chromatin homogeneity and decrease ASM and IDM (Nikolovski et al, 2019; Paunovic et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Association between Chromatin Structural Organization of Peripheral Blood Neutrophils and Self-Perceived Mental Stress: Gray-Level Co-occurrence Matrix Analysis

et al. 2021

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“…It is known that the dopamine and serotonin tissue levels in the striatum and other brain areas such as the cerebral cortex and the hippocampus, decrease as a consequence of 6-OHDA intrastriatal injection [ 23 , 24 , 25 ]. 6-OHDA selectively destroys dopaminergic neurons due to its high affinity to the dopamine transporter [ 26 , 27 ]. 6-OHDA can also destroy adjacent cells as a result of the formation of ROS [ 16 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Transcranial Focal Electrical Stimulation Modifies Biogenic Amines’ Alterations Induced by 6-Hydroxydopamine in Rat Brain

Santana-Gomez

Pérez-Pérez²,

Fonseca-Barriendos³

et al. 2021

Pharmaceuticals

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Transcranial focal stimulation (TFS) is a non-invasive neuromodulation strategy with neuroprotective effects. On the other hand, 6-hidroxidopamine (6-OHDA) induces neurodegeneration of the nigrostriatal system producing modifications in the dopaminergic, serotoninergic, and histaminergic systems. The present study was conducted to test whether repetitive application of TFS avoids the biogenic amines’ changes induced by the intrastriatal injection of 6-OHDA. Experiments were designed to determine the tissue content of dopamine, serotonin, and histamine in the brain of animals injected with 6-OHDA and then receiving daily TFS for 21 days. Tissue content of biogenic amines was evaluated in the cerebral cortex, hippocampus, amygdala, and striatum, ipsi- and contralateral to the side of 6-OHDA injection. Results obtained were compared to animals with 6-OHDA, TFS alone, and a Sham group. The present study revealed that TFS did not avoid the changes in the tissue content of dopamine in striatum. However, TFS was able to avoid several of the changes induced by 6-OHDA in the tissue content of dopamine, serotonin, and histamine in the different brain areas evaluated. Interestingly, TFS alone did not induce significant changes in the different brain areas evaluated. The present study showed that repetitive TFS avoids the biogenic amines’ changes induced by 6-OHDA. TFS can represent a new therapeutic strategy to avoid the neurotoxicity induced by 6-OHDA.

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Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology

Cited by 22 publications

References 54 publications

Application of fractal and textural analysis in medical physiology, pathophysiology and pathology

Application of fractal and textural analysis in medical physiology, pathophysiology and pathology

Association between Chromatin Structural Organization of Peripheral Blood Neutrophils and Self-Perceived Mental Stress: Gray-Level Co-occurrence Matrix Analysis

Transcranial Focal Electrical Stimulation Modifies Biogenic Amines’ Alterations Induced by 6-Hydroxydopamine in Rat Brain

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