Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

González, Lydia; Martin-Romera, Javier D.; Sánchez-Sánchez, Purificación; Navarro, Jorge A. R.; Barea, Elisa; Maldonado, Carmen R.; Carmona, Francisco javier García

doi:10.1021/acs.inorgchem.3c00121

Cited by 4 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The consequences of AChE inhibition are paralysis, respiratory failures, seizures, or even death. In this regard, MOF-808 has also proved to act as a potential antidote for the treatment of OP-poisoning by removing a toxic OP-compound from simulated physiological media and, therefore, avoiding the interaction of the toxic molecule with the targeted AChE enzyme …”

Section: Resultsmentioning

confidence: 99%

Short-Peptide Supramolecular Hydrogels for In Situ Growth of Metal–Organic Framework-Peptide Biocomposites

Illescas‐Lopez

Martin-Romera

Mañas‐Torres

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

The development of bio-MOFs or MOF biocomposites through the combination of MOFs with biopolymers offers the possibility of expanding the potential applications of MOFs, making use of more environmentally benign processes and reagents and giving rise to a new generation of greener and more bio-oriented composite materials. Now, with the increasing use of MOFs for biotechnological applications, the development of new protocols and materials to obtain novel bio-MOFs compatible with biomedical or biotechnological uses is needed. Herein, and as a proof of concept, we have explored the possibility of using short-peptide supramolecular hydrogels as media to promote the growth of MOF particles, giving rise to a new family of bio-MOFs. Short-peptide supramolecular hydrogels are very versatile materials that have shown excellent in vitro and in vivo biomedical applications such as tissue engineering and drug delivery vehicles, among others. These peptides self-assemble by noncovalent interactions, and, as such, these hydrogels are easily reversible, being more biocompatible and biodegradable. These peptides can self-assemble by a multitude of stimuli, such as changes in pH, temperature, solvent, adding salts, enzymatic activity, and so forth. In this work, we have taken advantage of this ability to promote peptide self-assembly with some of the components required to form MOF particles, giving rise to more homogeneous and well-integrated composite materials. Hydrogel formation has been triggered using Zn 2+ salts, required to form ZIF-8, and formic acid, required to form MOF-808. Two different protocols for the in situ MOF growth have been developed. Finally, the MOF-808 composite hydrogel has been tested for the decontamination of water polluted with phosphate ions as well as for the catalytic degradation of toxic organophosphate methyl paraoxon in an unbuffered solution.

show abstract

Section: Resultsmentioning

confidence: 99%

Short-Peptide Supramolecular Hydrogels for In Situ Growth of Metal–Organic Framework-Peptide Biocomposites

Illescas‐Lopez

Martin-Romera

Mañas‐Torres

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…Organophosphate (OP)-based pesticides and chemical warfare nerve agents are extremely toxic compounds, as a consequence of the central nervous system damage by irreversible inhibition of acetylcholinesterase (AChE) activity. , In this regard, much effort has been devoted to develop materials for protection against exposure to OP compounds, particularly filters and detoxication catalysts. − However, disruptive antidotes for OP poisoning are underexplored. , In this regard, current OP poisoning treatment is based on the nucleophilic attack of oxime-based drugs on the phosphorylated AChE (OP@AChE) adduct with the aim to restore AChE function and recover a normal neurotransmission process. However, while low oxime concentrations lead to an inefficient AChE reactivation, large amounts of reactivators have shown to inhibit the enzyme and lead to severe toxicity issues. , In addition, poor permeability through the blood–brain barrier limits the efficiency of the oxime treatment …”

Section: Introductionmentioning

confidence: 99%

“… 3 − 7 However, disruptive antidotes for OP poisoning are underexplored. 8 , 9 In this regard, current OP poisoning treatment is based on the nucleophilic attack of oxime-based drugs on the phosphorylated AChE (OP@AChE) adduct with the aim to restore AChE function and recover a normal neurotransmission process. However, while low oxime concentrations lead to an inefficient AChE reactivation, large amounts of reactivators have shown to inhibit the enzyme and lead to severe toxicity issues.…”

Section: Introductionmentioning

confidence: 99%

Organophosphate Detoxification and Acetylcholinesterase Reactivation Triggered by Zeolitic Imidazolate Framework Structural Degradation

Martin-Romera,

Borrego-Marin,

Jabalera-Ortiz

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Organophosphate (OP) toxicity is related to inhibition of acetylcholinesterase (AChE) activity, which plays a key role in the neurotransmission process. In this work, we report the ability of different zinc zeolitic imidazolate frameworks (ZIFs) to behave as potential antidotes against OP poisoning. The Zn−L coordination bond (L = purine, benzimidazole, imidazole, or 2methylimidazole) is sensitive to the G-type nerve agent model compounds diisopropylfluorophosphate (DIFP) and diisopropylchlorophosphate, leading to P−X (X = F or Cl) bond breakdown into nontoxic diisopropylphosphate. P−X hydrolysis is accompanied by ZIF structural degradation (Zn−imidazolate bond hydrolysis), with the concomitant release of the imidazolate linkers and zinc ions representing up to 95% of ZIF particle dissolution. The delivered imidazolate nucleophilic attack on the OP@AChE adduct gives rise to the recovery of AChE enzymatic function. P−X bond breakdown, ZIF structural degradation, and AChE reactivation are dependent on imidazolate linker nucleophilicity, framework topology, and particle size. The best performance is obtained for 20 nm nanoparticles (NPs) of Zn(2-methylimidazolate) 2 (sod ZIF-8) exhibiting a DIFP degradation half-life of 2.6 min and full recovery of AChE activity within 1 h. 20 nm sod ZIF-8 NPs are not neurotoxic, as proven by in vitro neuroblastoma cell culture viability tests.

show abstract

“…Metal–organic frameworks (MOFs) make up a class of porous and crystalline inorganic materials characterized by large surface area, abundant adsorption sites, tailorable structures, and semiconducting properties. − These unique structures and intriguing properties have made them useful photocatalysts in the past several decades. However, the low separation rate of photoinduced charge carriers and poor stability lead to limited light availability and photocatalytic properties .…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Catalytic Activity of Laccase@Copper–Metal–Organic Framework Nanofractal Microspheres: Synergistic Contribution of the Mass Transfer and Electron Transfer Pathway

Yang,

Wang,

Huang

et al. 2024

Inorg. Chem.

View full text Add to dashboard Cite

Metal−organic frameworks (MOFs) are limited by small pores and buried active sites, and their enzyme-like catalytic activity is still very low. Herein, laccase was employed as the organic component to construct laccase@Cu 3 (BTC) 2 nanofractal microspheres. During the preparation process, laccase adsorbed Cu 2+ by electrostatic attractive interaction, then combined with Cu 2+ by coordination interaction, and finally induced the in situ growth of H 3 BTC 2 in multiple directions by electrostatic repulsion. Interestingly, electrostatic repulsion was tuned efficiently by adjusting the Cu 2+ concentration to obtain laccase@Cu 3 (BTC) 2 nanofractal microspheres (nanosheet microspheres, nanorod microspheres, and nanoneedle microspheres). Laccase@Cu 3 (BTC) 2 nanorod microspheres exhibited the highest catalytic efficiency, which was 14-fold higher than that of smooth microspheres. The mechanism of the improvement of catalytic activity in the degradation of BPA was proposed for the first time. The enhanced catalytic activity depended on the adsorption effect of the nanorod framework and dual cycle synergistic catalysis of Cu + /Cu 2+ active sites, which accelerated substrate diffusion and electron transfer. The catalytic mechanism of enzyme@MOF nanofractal microspheres not only deepens our understanding of enzyme and MOF synergistic catalysis but also provides new insights into the design of catalysts.

show abstract

Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

Cited by 4 publications

References 18 publications

Short-Peptide Supramolecular Hydrogels for In Situ Growth of Metal–Organic Framework-Peptide Biocomposites

Short-Peptide Supramolecular Hydrogels for In Situ Growth of Metal–Organic Framework-Peptide Biocomposites

Organophosphate Detoxification and Acetylcholinesterase Reactivation Triggered by Zeolitic Imidazolate Framework Structural Degradation

Enhancing the Catalytic Activity of Laccase@Copper–Metal–Organic Framework Nanofractal Microspheres: Synergistic Contribution of the Mass Transfer and Electron Transfer Pathway

Contact Info

Product

Resources

About