Oxygen enhancement ratios (OERS) for somatic mutations in tradescantia stamen hairs

Underbrink, A. G.; Sparrow, A.H.; Sautkulis, Diane; Mills, Robert E.

doi:10.1016/s0033-7560(75)80004-4

Cited by 19 publications

(6 citation statements)

References 15 publications

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“…Figure 7. The induction of mutations in Tradescantia stamen hairs after gamma and neutron exposures under oxygen and nitrogen which reveals the same peak height in each case (Underbrink et al 1975).…”

Section: The Data and Its Interpretationmentioning

confidence: 63%

Radiation induced cancer arises from a somatic mutation

Chadwick¹,

Leenhouts²

2011

J. Radiol. Prot.

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Experimental data from the literature are presented to create a chain which links radiation induced cancer in animals to cell reproductive death and then to chromosomal aberrations and somatic mutations. The cancer data reveal the same peak value of cancer induction following different radiation exposures which leads to an association between cancer induction and cell killing. Other data show a direct correlation between cell survival and chromosomal aberration yield independent of whether a sensitiser is used or not. Data on the induction of somatic mutations in mammalian cultured cells show the same direct relationship between mutation frequency and cell killing following neutron and gamma ray exposures. Taken as a whole, the experimental data provide convincing evidence that radiation induced cancer arises from chromosomal damage.

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Section: The Data and Its Interpretationmentioning

confidence: 63%

Radiation induced cancer arises from a somatic mutation

Chadwick¹,

Leenhouts²

2011

J. Radiol. Prot.

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“…The reason is that extremely large numbers of exposed cells can be examined. Accordingly, it has been possible in earlier studies [1][2][3][4] to determine not only the dose-effect relations for neutrons but to obtain also accurate results concerning the initial linear component of the dose-effect relation for X rays [1,2]. The present study goes one step further.…”

Section: Introductionmentioning

confidence: 75%

“…Previous extensive experiments with monoenergetic neutrons and with X rays have led to the conclusion that the induction of pink somatic mutations in stamen hairs of Tradescantia clone 02 follows a linear-quadratic relation in absorbed dose at low and intermediate dose levels [1][2][3][4]. The linear component in the dose-effect relation represents the intra-track effect, i.e., it results from the synergism of lesions produced by the same particle track.…”

Section: Introductionmentioning

confidence: 99%

Comparison of X-ray and gamma-ray dose-response curves for pink somatic mutations in Tradescantia clone 02

Underbrink

Kellerer

Mills

et al. 1976

Radiat Environ Biophys

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Summary.Microdosimetric data indicate that the mean specific energy, ~, produced by individual charged particles from X rays and gamma rays is different for the two radiation qualities by nearly a factor of two. In order to test whether this influences the initial, linear component in the dose-effect relations, a comparison was made between dose-response curves for pink somatic mutations in Tradescantia clone 02 stamen hairs following X and gamma irradiations. Absorbed doses ranged from 2.66 to 300 rad. The results are in agreement with predictions made on the basis of microdosimetric data. At low doses gamma rays are substantially less effective than X rays. The RBE of gamma rays vs. X rays at low doses was approximately 0.6, a value lower than those usually reported in other experimental systems.

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“…1972, Underbrink and Sparrow 1974, Underbrink et al . 1975) and have all been plotted in a standard fashion, that is, by computing the slope and fitting a regression line through the data points for each dose-response curve, with standard errors for each point .…”

Section: Presentation Of Datamentioning

confidence: 99%

“…When experiments at this energy were repeated with a different type of exposure fixture designed to determine o .e .r . values (Underbrink, Sparrow, Sautkulis and Mills 1975), the r.b .e . at 0 .…”

mentioning

confidence: 99%

An Elusive Factor Affecting Mutation Frequency inTradescantiaStamen Hairs: Its Influence on R.B.E.

Underbrink

Sparrow

Sautkulis

et al. 1975

International Journal of Radiation Biology and Related Studies

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A comparison of data from several experiments designed to determine either relative biological effectiveness (r.b.e.) or oxygen-enhancement ratios (o.e.r.) as a function of neutron energy revealed a puzzling variability in mutational response for pink mutations in Tradescantia stamen hairs. For some reason that we cannot determine, when the exposure fixtures and accompanying experimental procedures were changed as necessitated by the two studies, the expected mutation frequencies changed for X-rays and for four neutron energies. The other four neutron energies gave the expected results. As a consequence of these changes in mutation frequencies, the magnitude of r.b.e. values changed as well as the relationship of r.b.e. to neutron energy. Consequently, when r.b.e. values were determined using a closed but aerated exposure fixture instead of exposures made in free air, the resulting r.b.e. versus neutron-energy curve more closely paralleled that found by others for the inhibiton of root growth in Vicia faba.

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Oxygen enhancement ratios (OERS) for somatic mutations in tradescantia stamen hairs

Cited by 19 publications

References 15 publications

Radiation induced cancer arises from a somatic mutation

Radiation induced cancer arises from a somatic mutation

Comparison of X-ray and gamma-ray dose-response curves for pink somatic mutations in Tradescantia clone 02

An Elusive Factor Affecting Mutation Frequency inTradescantiaStamen Hairs: Its Influence on R.B.E.

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