Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy

Abstract

Radiotherapy (RT), the most commonly used treatment method in clinic, shows its unique advantages such as strong penetration, high energy intensity, and low systemic side effects. However, in vivo tumor...

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs

“…It is often challenging to completely eradicate tumors using a single method, and employing multiple modes of therapy can effectively destroy the tumor while reducing side effects. , CBN can be used for multimodal cancer therapy (Table ), including chemodynamic therapy (CDT), RT, PTT, PDT, sonodynamic therapy (SDT), chemotherapy, immunotherapy, starvation therapy, and gas therapy. ,, Due to their excellent drug-loading capability, CBN are well-suited for multimode cancer treatment. External stimulation can activate cell stress reactions (CSR), which counteract the antitumor effect.…”

Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics

“…Actually, Ferrihydrites, functioning as inorganic CAT, have demonstrated in vivo their ability to produce O 2 within the tumor microenvironment, leading to a substantial enhancement of the therapeutic effect of radiotherapy. 49 , 52 …”

Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors

“…The combination of oxygen microcapsules and RT suppressed HIF-1α expression and induced M2-type TAM polarization into M1-type [ 200 ]. Notably, the hypoxic TME significantly impedes the efficacy of RT, and the RT process further depletes oxygen within the tumor tissue [ 294 ]. Hence, through hypoxia mitigation, nanomaterials serve as inhibitors of the HIF-1α signaling pathway and demonstrate a significant enhancement in RT efficacy.…”