Oxygen in Wound Healing

Eisenbud, David E.

doi:10.1016/j.cps.2012.05.001

Cited by 77 publications

(42 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Controversy exists as to whether continued prosthetic use is indicated for amputees with RL ulcerations because ambulation has many physiological benefits that improve wound healing (15), such as increased circulation (16), tissue oxygenation (16,17), and fluid filtration (17). Prolonged inactivity, which is often associated with prosthetic disuse, is associated with several deleterious effects on health, including reduced functional capacity, respiratory function, skin integrity, and oxygen transportation (17) as well as muscle atrophy (18).…”

Section: Discussionmentioning

confidence: 99%

Interventions to Manage Residual Limb Ulceration Due To Prosthetic Use in Individuals with Lower Extremity Amputation: A Systematic Review of the Literature

Highsmith¹,

Kahle²,

Klenow³

et al. 2016

technol innov

View full text Add to dashboard Cite

Patients with lower extremity amputation (LEA) experience 65% more dermatologic issues than non-amputees, and skin problems are experienced by ≈75% of LEA patients who use prostheses. Continuously referring LEA patients to a dermatologist for every stump related skin condition may be impractical. Thus, physical rehabilitation professionals should be prepared to recognize and manage common non-emergent skin conditions in this population. The purpose of this study was to determine the quantity, quality, and strength of available evidence supporting treatment methods for prosthesis-related residual limb (RL) ulcers. Systematic literature review with evidence grading and synthesis of empirical evidence statements (EES) was employed. Three EESs were formulated describing ulcer etiology, conditions in which prosthetic continuance is practical, circumstances likely requiring prosthetic discontinuance, and the consideration of additional medical or surgical interventions. Continued prosthetic use is a viable option to manage minor or early-stage ulcerated residual limbs in compliant patients lacking multiple comorbidities. Prosthetic discontinuance is also a viable method of residual limb ulcer healing and may be favored in the presence of severe acute ulcerations, chronic heavy smoking, intractable pain, rapid volume and weight change, history of chronic ulceration, systemic infections, or advanced dysvascular etiology. Surgery or other interventions may also be necessary in such cases to achieve restored prosthetic ambulation. A short bout of prosthetic discontinuance with a staged re-introduction plan is another viable option that may be warranted in patients with ulceration due to poor RL volume management. High-quality prospective research with larger samples is needed to determine the most appropriate course of treatment when a person with LEA develops an RL ulcer that is associated with prosthetic use.

show abstract

Section: Discussionmentioning

confidence: 99%

Interventions to Manage Residual Limb Ulceration Due To Prosthetic Use in Individuals with Lower Extremity Amputation: A Systematic Review of the Literature

Highsmith¹,

Kahle²,

Klenow³

et al. 2016

technol innov

View full text Add to dashboard Cite

show abstract

“…The wound bed of acute and chronic wounds involves a well - orchestrated and finely balanced milieu of proteins, cytokines and chemokines that ensure a timely return to local and gross homeostasis. Dynamic reciprocity and wound bed redox signaling are essential components of a healthy, healing wound bed [31, 32, 33, 34]. Redox signaling, and in particular the roles of reactive oxygen species (ROS)/free radicals, free radical quenchers/antioxidants (e.g.…”

Section: Introductionmentioning

confidence: 99%

Pig dorsum model for examining impaired wound healing at the skin-implant interface of percutaneous devices

Holt

Betz

Ford

et al. 2013

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Percutaneous medical devices are indispensable in contemporary clinical practice, but the associated incidence of low to moderate mortality infections represents a significant economic and personal cost to patients and healthcare providers. Percutaneous osseointegrated prosthetics also suffer from a similar risk of infection, limiting their clinical acceptance and usage in patients with limb loss. We hypothesized that transepidermal water loss management (TEWL) at the skin-implant interface may improve and maintain a stable skin-to-implant interface. In this study, skin reactions in a 3-month, pig dorsum model were assessed using standard histology, immunohistochemistry, and quantitative image analysis. Immunohistochemical analysis of peri-implant tissue explants showed evidence of: continuous healing (cytokeratin 6+), hypergranulation tissue (procollagen+), hyper-vascularity (Collagen 4+), and the presence of fibrocytes (CD45+ and procollagen type 1+). Importantly, the gross skin response was correlated to a previous load-bearing percutaneous osseointegrated prosthetic sheep study conducted in our lab. The skin responses of the two models indicated a potentially shared mechanism of wound healing behavior at the skin-implant interface. Although TEWL management did not reduce skin migration at the skin-implant interface, the correlation of qualitative and quantitative measures validated the pig dorsum model as a high-throughput platform for translational science based percutaneous interface investigations in the future.

show abstract

“…As well as being required for energy production in mitochondria (ATP), oxygen plays an important role in many other processes like antimicrobial defence, cell proliferation, generation and maintenance of extracellular matrix, angiogenesis and cell movement. 12,13,15,16 In an acute wound, the disruption of capillaries leads to a transient local decrease of oxygen within the wound resulting in inadequate oxygenation of the tissue (hypoxia). It is well known that hypoxia serves as one of the initial stimuli to accelerate wound healing mainly via the transcription factor hypoxia-inducible factor-1 (HIF-1).…”

Section: Chronic Woundsmentioning

confidence: 99%

<p>Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox<sup>®</sup>) in the Management of Chronic Wounds</p>

Kröger¹,

Gäbel²,

Juntermanns³

2020

CWCMR

View full text Add to dashboard Cite

Wound healing is a complex and orchestrated process. Oxygen is one of the molecules that is required throughout the wound healing continuum for various underlying processes from innate immune response at the inflammatory phase to building of collagen type III at the remodelling phase. Therefore, it is not surprising that, due to primary diseases like venous insufficiency and diabetes mellitus, hypoxia caused by sustained lack of oxygen is common in chronic wounds. Adjunct to systemic therapies of the primary disease aimed at revascularizing the tissue, recently developed technologies are now available that provide topical oxygen-enhanced wound healing. Several devices are designed to provide pure oxygen directly to the wound either with or without pressure. Another approach to the provision of additional topical oxygen is to use haemoglobin to facilitate oxygen diffusion. This phenomenon was first shown more than 50 years ago, but it has only recently been discovered as a means of improving wound healing. In vitro and in vivo studies have shown that haemoglobin is capable of transporting oxygen outside of erythrocytes. Furthermore, several clinical studies have shown a beneficial effect on wound healing in different wound types. In this review, we summarise publicly available in vitro and in vivo clinical data and discuss the acceptability and ease of use of haemoglobin spray (Granulox ® ) in the management of chronic wounds. In conclusion, currently available data are promising, demonstrating that purified haemoglobin in an aqueous solution is able to serve as an oxygen shuttle by facilitating diffusion. No severe side effects have been reported in the literature, implying that it is a safe product. In clinical studies, it has been observed to improve the speed of healing of different types of chronic wounds. As a simple spray, it can be used as adjunct treatment in many standard-of-care settings with only a few limitations.

show abstract

Oxygen in Wound Healing

Cited by 77 publications

References 56 publications

Interventions to Manage Residual Limb Ulceration Due To Prosthetic Use in Individuals with Lower Extremity Amputation: A Systematic Review of the Literature

Interventions to Manage Residual Limb Ulceration Due To Prosthetic Use in Individuals with Lower Extremity Amputation: A Systematic Review of the Literature

Pig dorsum model for examining impaired wound healing at the skin-implant interface of percutaneous devices

<p>Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox<sup>®</sup>) in the Management of Chronic Wounds</p>

Contact Info

Product

Resources

About