Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study

de Sire, Alessandro; Marotta, Nicola; Sconza, Cristiano; Lippi, Lorenzo; Drago Ferrante, Vera; Respizzi, Stefano; Invernizzi, Marco; Ammendolia, Antonio

doi:10.1080/09638288.2024.2342491

Disability and Rehabilitation

2024

DOI: 10.1080/09638288.2024.2342491

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Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study

Alessandro de Sire,

Nicola Marotta,

Cristiano Sconza

et al.

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Cited by 2 publications

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Oxygen-ozone therapy for musculoskeletal pain in rehabilitation: Evidence and future perspectives

Invernizzi,

de Sire

2024

BMR

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Dear colleagues,Musculoskeletal pain is a common issue in several pathological conditions like osteoarthritis and low back pain, with relevant negative implications in terms of chronic pain development, disability and increased sanitary costs worldwide [?]. As the search for minimally invasive treatment options intensifies, oxygen-ozone therapy has emerged as a promising intervention and its anti-inflammatory and tissue-regenerative properties makes it as a viable alternative to more conventional treatments like corticosteroid injections [?,?].This editorial focusses on the current evidence supporting oxygen-ozone therapy, in particular in osteoarthritis and low back pain treatment, and explores its potential integration with other therapeutic strategies like physical rehabilitation interventions.Recent studies highlighted the role of oxygen-ozone therapy in the management of knee [?

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Oxygen-ozone therapy for musculoskeletal pain in rehabilitation: Evidence and future perspectives

Invernizzi,

de Sire

2024

BMR

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The Effect of Intra-Articular Injections of Hyaluronic Acid for the Treatment of Trapezio-Metacarpal Joint Osteoarthritis

Agostini,

Bressanin,

de Sire

et al. 2024

JPM

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Background: Osteoarthritis of the basal thumb joint is a debilitating disease with a high prevalence. Among pharmacological treatments, intra-articular injections of hyaluronic acid have been clinically applied. This study aimed to investigate the effectiveness and safety of intra-articular injections of hyaluronic acid for the treatment of trapezio-metacarpal joint osteoarthritis (TMOA), over a one-year period. Methods: Patients with TMOA were enrolled and treated with five consecutive intra-articular injections of hyaluronic acid (20 mg/2 mL, 500–750 KDa, HyalganBio) at weekly intervals. Primary outcomes were pain during different activities (changes in numerical rating scale) and function (pinch and grip strength), and secondary outcomes were safety (adverse events) and patient-reported outcomes (quick-DASH and SF-12). The outcomes were evaluated at baseline and 1-, 3-, 6-, and 12- months after the last injection. Results: A total of 29 patients were included. All participants completed the five injective sessions and the first follow-up. A total of 15 patients completed the study. During the follow-up period, intra-articular injections of hyaluronic acid have significantly reduced spontaneous and provoked pain and improved disability. No severe systemic adverse events were reported. Conclusions: At a follow-up of up to 12 months, patients with TMOA treated with intra-articular hyaluronic acid injections reported improvements in pain relief and quality of life.

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Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study

Cited by 2 publications

References 48 publications

Oxygen-ozone therapy for musculoskeletal pain in rehabilitation: Evidence and future perspectives

Oxygen-ozone therapy for musculoskeletal pain in rehabilitation: Evidence and future perspectives

The Effect of Intra-Articular Injections of Hyaluronic Acid for the Treatment of Trapezio-Metacarpal Joint Osteoarthritis

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