Oxygen-Producing Gellan Gum Hydrogels for Dual Delivery of Either Oxygen or Peroxide with Doxorubicin

Newland, Ben; Baeger, Marcel; Eigel, Dimitri; Newland, Heike; Werner, Carsten

doi:10.1021/acsbiomaterials.7b00078

Cited by 49 publications

(40 citation statements)

References 37 publications

(64 reference statements)

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“… 5 Materials that carry and release oxygen, such as fluorinated oils and hemoglobin based oxygen carriers, have long been studied, especially in the context of blood substitues. 6 Biomaterials that produce oxygen require an oxygen source such as sodium percarbonate, 7 calcium peroxide 8 – 11 or sodium peroxide. 12 Upon contact with water, and/or catalase, these oxygen sources break down to yield molecular oxygen and water.…”

mentioning

confidence: 99%

Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

et al. 2018

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confidence: 99%

Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

et al. 2018

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“…Previously, scaffolds loaded with CP have been used for oxygen release 98 . Converting hydrogen peroxide from CP to water and oxygen can be useful for tissue engineering applications 99 , 100 .…”

Section: Discussionmentioning

confidence: 99%

Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties

Joshi‐Navare

Colombani

Rezaeeyazdi

et al. 2020

Sci Rep

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Porous three-dimensional hydrogel scaffolds have an exquisite ability to promote tissue repair. However, because of their high water content and invasive nature during surgical implantation, hydrogels are at an increased risk of bacterial infection. Recently, we have developed elastic biomimetic cryogels, an advanced type of polymeric hydrogel, that are syringe-deliverable through hypodermic needles. These needle-injectable cryogels have unique properties, including large and interconnected pores, mechanical robustness, and shape-memory. Like hydrogels, cryogels are also susceptible to colonization by microbial pathogens. To that end, our minimally invasive cryogels have been engineered to address this challenge. Specifically, we hybridized the cryogels with calcium peroxide microparticles to controllably produce bactericidal hydrogen peroxide. Our novel microcomposite cryogels exhibit antimicrobial properties and inhibit antibiotic-resistant bacteria (MRSA and Pseudomonas aeruginosa), the most common cause of biomaterial implant failure in modern medicine. Moreover, the cryogels showed negligible cytotoxicity toward murine fibroblasts and prevented activation of primary bone marrow-derived dendritic cells ex vivo. Finally, in vivo data suggested tissue integration, biodegradation, and minimal host inflammatory responses when the antimicrobial cryogels, even when purposely contaminated with bacteria, were subcutaneously injected in mice. Collectively, these needle-injectable microcomposite cryogels show great promise for biomedical applications, especially in tissue engineering and regenerative medicine.

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“…Sun & Zhou, ), cutaneous delivery systems (Musazzi et al, ), and for antibiotic delivery during wound healing (Shukla & Shukla, ). Additionally, oxygen‐producing biomaterials were developed based on gellan gum (Newland, Baeger, Eigel, Newland, & Werner, ). Chitosan‐gellan gum systems (S. Kumar, Kaur, Bernela, Rani, & Thakur, ), and pectin‐gellan gum systems (Bera, Kumar, & Maiti, ; Fernandes, Fortes, da Cruz Fonseca, Breitkreutz, & Ferraz, ; Prezotti et al, ) are popular choices for smart drug delivery systems.…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Oxygen-Producing Gellan Gum Hydrogels for Dual Delivery of Either Oxygen or Peroxide with Doxorubicin

Cited by 49 publications

References 37 publications

Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties

Carbohydrate‐based nanomaterials for biomedical applications

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