Oxygen Reverses Deficits of Cognitive Function and Memory and Increased Heart Rate Induced by Acute Severe Isovolemic Anemia

Weiskopf, Richard B.; Feiner, John; Hopf, Harriet W.; Viele, Maurene; Watson, J. Throck; Kramer, Joel H.; Ho, Rachel; Toy, Pearl

doi:10.1097/00000542-200204000-00014

Cited by 147 publications

(107 citation statements)

References 4 publications

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“…These data suggest that limited oxygen delivery impacted neurological function at Hb values near 50-60 gÁL -1 . 63 Fig. 2 Schematic representation of arterial, microvascular, and tissue oxygen gradients in control, anemic, and anemic b-blocked rats derived from previously published experimental data.…”

Section: Hemodilution Results In Reduced Microvascular Tissue Pomentioning

confidence: 99%

Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle

Tsui

Dattani

Marsden

et al. 2010

Can J Anesth/J Can Anesth

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Section: Hemodilution Results In Reduced Microvascular Tissue Pomentioning

confidence: 99%

Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle

Tsui

Dattani

Marsden

et al. 2010

Can J Anesth/J Can Anesth

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“…It is appealing to correlate the Ht level to quality of life and energy scores as it has already been demonstrated in renal insufficiency and after chemotherapy. [21][22][23][24][25] Furthermore, Ht on the day following surgery and on the day of discharge were significantly higher in the EPO than in the ABD group. Assessment of early postoperative recovery, (vigour and functional ability) in surgical patients is considered to be important for optimizing patient rehabilitation, discharge planning and health system resource utilization.…”

mentioning

confidence: 86%

Deux injections d’érythropoïétine corrigent une anémie modérée chez la plupart des patients en attente d’une opération orthopédique

Rosencher

Poisson²,

Albi

et al. 2005

Can J Anesth/J Can Anesth

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B Ba ac ck kg gr ro ou un nd d: : The primary objective of this study was to assess the number of erythropoietin (EPO) injections required to reach a hematocrit (Ht) of 40% in moderately anemic patients. The secondary objective was to compare this strategy with autologous blood donation (ABD) in elective orthopedic surgery in terms of red blood cell (RBC) production.S St tu ud dy y d de es si ig gn n a an nd d m me et th ho od ds s: : 93 patients with a baseline Ht between 30 and 39% were randomized into two groups the day of the preoperative assessment. In the EPO group, patients received 40,000 UI/week sc until they reached a maximal Ht of 40%. In the ABD group, a RBC pack was collected every week as long as the Ht was above 33%.R Re es su ul lt ts s: : Two EPO injections were necessary to reach a 40% Ht in 63% of the patients. It was possible to collect two RBC packs in 45% of the patients in the ABD group. Volume of RBC production was significantly higher in the EPO group: 268 ± 142 mL vs 141 ± 129 (P = 0.0001). In the EPO group, Ht was significantly higher on days one and three after surgery and at discharge. The energy score was better in the EPO group. In the ABD group, 12.6% patients vs 6.5% in the EPO group received allogeneic transfusion (ns).C Co on nc cl lu us si io on n: : Only two EPO injections were sufficient to reach a Ht of 40% in the majority of patients. Therefore, to improve cost/effectiveness, the number of EPO injections should be related to baseline Ht instead of the four injections recommended in the product monograph. Objectif : Évaluer le nombre d'injections d'érythropoïétine (EPO) nécessaires pour atteindre un hématocrite (Ht) de 40 % chez des patients modérément anémiques. Aussi, comparer cette stratégie avec le don de sang autologue (DSA) en chirurgie orthopédique réglée en termes de production de globules rouges (GR). Méthode : Des patients (n = 93) présentant un Ht de base de 30 à 39 % ont été répartis en deux groupes le jour de l'évaluation

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“…Cognitive function and memory are usually affected at 6 g per 100 ml but can be partially corrected with supplemental oxygen. 45,46 Electrocardiographic changes occurred in only 5% of normal volunteers at Hb of 5 g per 100 ml. 47 A 1988 case-control study of surgical patients refusing blood transfusion found a 61.5% mortality with preoperative Hb o6.0 g per 100 ml.…”

Section: Rbc Transfusion In Stem Cell Transplantationmentioning

confidence: 99%