Oxygen-Self-Produced Nanoplatform for Relieving Hypoxia and Breaking Resistance to Sonodynamic Treatment of Pancreatic Cancer

Chen, Jie; Luo, Honglin; Liu, Yan; Zhang, Wei; Li, Hongxue; Luo, Tao; Zhang, Kun; Zhao, Yongxiang; Liu, Junjie

doi:10.1021/acsnano.7b08225

Cited by 388 publications

(265 citation statements)

References 52 publications

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“…US‐triggered SDT has been extensively explored for cancer therapy, which depends on the reactive oxygen species (ROS) production but the tumor hypoxia unfortunately induces the low ROS‐production efficacy . To solve this critical issue, an oxygen‐self‐produced nanoplatform was constructed for relieving the tumor hypoxia and enhancing the SDT‐therapeutic efficacy . Fluorocarbon (FC)‐chain‐functionalized hollow mesoporous organosilica nanoparticles (FHMONs) were chosen because the FC chain was similar to traditional PFC compounds for the affinity to oxygen via the hydrophobic interaction and hydrogen bonding ( Figure a), which could store oxygen molecules, deliver them into tumor tissue, and alleviate the hypoxia afterward.…”

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

“…Especially, US could enhance intracellular uptake of nanosonosensitizers by “sonoporation effect” and further improve the therapeutic efficacy because of the high tissue‐penetrating depth of US. This strategy could break the barriers for nanoparticle delivery, deliver oxygen for modulating the tumor hypoxia, mitigate the hypoxia‐induced resistance to SDT, and improve the SDT‐therapeutic efficacy subsequently, which has achieved the high tumor‐suppression outcome and improved survival rate on tumor‐bearing mice …”

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

“…b) The scheme of in vivo therapeutic principles of oxygen‐self‐produced IR780@O 2 ‐FHMON on combating hypoxia PANC‐1 solid tumor via SDT, including breaking hypoxia‐specific transport barriers, releasing O 2 to relief hypoxia, mitigating the hypoxia‐induced resistance to SDT, and enhancing the SDT efficacy subsequently. Reproduced with permission . Copyright 2017, American Chemical Society.…”

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

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Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

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Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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“…[343][344][345][346] Chen's team has been aggressively explored synergistic SDT for cancer therapeutics based on nanomedicine. SDT has the advantages in deeper tissue penetration and nonphototoxicity to NT compared with PDT, providing a promising cancer therapy paradigm and receiving an increasing amount of research attention.…”

Section: Other Synergistic Surgerymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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“…A comprehensive understanding of TME is a prerequisite of establishing high‐efficient treatment approaches 2. Therefore, monitoring TMEs' biomarkers using many clinically noninvasive medical imaging technologies, e.g., ultrasound (US), photoacoustic (PA), magnetic resonance imaging (MRI), has aroused considerable attention with the progress of bio‐nanotechnology 3.…”

Section: Introductionmentioning

confidence: 99%

Coordination‐Responsive Longitudinal Relaxation Tuning as a Versatile MRI Sensing Protocol for Malignancy Targets

et al. 2018

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Biomarkers (e.g., acidity, H2O2, hypoxia, and specific molecules) as one primary component of tumor microenvironments are closely associated with occurrence, invasion, and metastasis of malignancy, thus can act as biological targets. However, their monitoring remains a challenging task. Herein, a coordination‐dependent longitudinal relaxation tuning (CLRT) that occurs between a Mn2+ “donor” and a Mn2+ “acceptor” is established to enable biological target sensing. Relying on the differences of coordination ability and spatial structure between donors and acceptors, the biological targets as Mn2+ acceptor can take Mn2+ away from the donors (i.e., modified ligands) in nanoscale probes, which consequently varies T1‐weighted (T1W) magnetic resonance imaging (MRI) signal. The coordination ability and spatial structure of the modified Mn2+ “donor” and the pore diameter of donor carrier are demonstrated to determine the feasibility, specificity, and generality of CLRT. With CLRT, this MRI‐based ruler is demonstrated for the successful specific detection of biological targets (i.e., hyaluronic acid and glutathione) of malignancy, and its potential in quantitative measurement of hyaluronic acid is further demonstrated. CLRT can serve as a novel and general sensing principle to augment the exploration of a wide range of biological systems.

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Oxygen-Self-Produced Nanoplatform for Relieving Hypoxia and Breaking Resistance to Sonodynamic Treatment of Pancreatic Cancer

Cited by 388 publications

References 52 publications

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Coordination‐Responsive Longitudinal Relaxation Tuning as a Versatile MRI Sensing Protocol for Malignancy Targets

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