Oxyresveratrol ameliorates allergic airway inflammation via attenuation of IL-4, IL-5, and IL-13 expression levels

Ashraf, Muhammad Imran; Shahzad, Muhammad; Shabbir, Arham

doi:10.1016/j.cyto.2015.09.013

Cited by 43 publications

(27 citation statements)

References 45 publications

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“…As we know, IFN-γ is involved in the allergic inflammation, such as asthma and DTH ( 19 , 20 ). However, it is worth noting that IL-4 also participates in the immune progress ( 21 , 22 ). The Th1/Th2 paradigm assumes that a dominance of Th1 cell activation and an inadequate Th2 cell response are responsible for the development of inflammation, suggesting the balance of Th1/Th2 is important to regulate immune response ( 23 – 25 ).…”

Section: Discussionmentioning

confidence: 99%

Puerarin alleviates delayed-type hypersensitivity via cytokine inhibition by modulating Th1/Th2 balance

Tong

Cai

et al. 2018

Exp Ther Med

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Puerarin has long been used as a traditional Chinese medicine, which possesses various physiological properties, including anti-inflammation, anti-oxidative, anti-diabetic and anti-cancer activities. The aim of the current study was to investigate the effect of puerarin on delayed-type hypersensitivity (DTH) induced by ovalbumin (OVA) in mice and explore its underlying mechanisms. The results showed that puerarin significantly attenuated DTH, resulting from a decrement in footpad swelling, reduction in inflammatory cell as well as a decline in anti-OVA IgG in serum. In the homogenized supernatant of footpad tissues, the classic Th1-cytokines, including interferon (IFN)-γ was suppressed following puerarin treatment. Furthermore, a high dose of puerarin inhibited interleukin (IL)-4 production, the classic Th2-cytokine. The concanavalin A stimulation and MTT assays indicated a suppressive effect of puerarin on Th1 response via decreasing IFN-γ production in OVA-primed lymphocytes. Detailed studies revealed that puerarin modulated the Th1/Th2 balance in DTH responses, attributing to lower T-bet/GATA binding protein-3 mRNA and protein level ratios, which led to the shift change of IFN-γ/IL-4 with puerarin treatment. These findings demonstrate that puerarin alleviated inflammation in DTH triggered by OVA application via curbing inflammatory cytokines by modulating the Th1/Th2 balance. These results suggest that puerarin may be an alternative therapeutic option for the treatment of DTH.

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Section: Discussionmentioning

confidence: 99%

Puerarin alleviates delayed-type hypersensitivity via cytokine inhibition by modulating Th1/Th2 balance

Tong

Cai

et al. 2018

Exp Ther Med

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“…The present study demonstrated that oxyresveratrol significantly increased the SCI-mediated activities. Andrabi et al (15) demonstrated that oxyresveratrol inhibits apoptotic cell death during transient cerebral ischemia, whereas Ashraf et al (23) indicated that the compound ameliorates inflammation in the airways following an allergic response.…”

Section: Discussionmentioning

confidence: 99%

The effects of oxyresveratrol abrogates inflammation and oxidative stress in rat model of spinal cord injury

Chen

et al. 2017

Mol Med Report

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Oxyresveratrol and its glycoside are important natural active materials. As an effective tyrosine kinase inhibitor, oxyresveratrol may prevent herpes virus infection, inflammation and oxidative stress, as well as protect nerves. In addition, it is known to inhibit cell apoptosis following cerebral ischemia. In recent years, oxyresveratrol and its glycoside have been widely investigated, and their useful biological activities have been explored, indicating that they may be worthy of further comprehensive research. The aim of the present study was to evaluate the photoprotective effects of oxyresveratrol and its ability to abrogate inflammation and oxidative stress in a rat model of spinal cord injury (SCI). The authors identified that oxyresveratrol significantly reversed the SCI‑induced inhibition of Basso, Beattie, and Bresnahan scores, inhibited the SCI‑mediated increase in spinal cord water content, significantly suppressed SCI‑induced nuclear factor‑κB/p65, tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6 activities and reversed the malondialdehyde, superoxide dismutase, glutathione (GSH) and GSH peroxidase activities in SCI rats. SCI‑induced granulocyte‑macrophage colony‑stimulating factor (GM‑CSF), inducible nitric oxide synthase (iNOS) and cyclo‑oxygenase‑2 (COX‑2) protein expression was significantly suppressed by oxyresveratrol, and SCI‑mediated inhibition of nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) protein expression was significantly increased by oxyresveratrol. In conclusion, these results suggest that the effects of oxyresveratrol restores SCI, and abrogates inflammation and oxidative stress in rat model of SCI via the GM‑CSF, iNOS, COX‑2 and Nrf2 signaling pathway.

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“…Resveratrol induced apoptosis of human keratinocyte by activating Sirt1 while attenuating inflammation in house dust mite‐induced AD in mice by down‐regulating high mobility group box (HMGB)1 protein expression (Lee et al , ; Karuppagounder et al , ). Other SCR constituents that were shown to have immunosuppressive and antiinflammatory activities with potential for modulation of AD include astilbin (Guo et al , ), oxyresveratrol (Ashraf et al , ), catechin (Hisano et al , ), taxifolin (Kim et al , ), engeletin (Huang et al , ), and quercetin (Vijayalakshmi et al , ; Karuppagounder et al , ; Weng et al , ). Thus, it appears that the various beneficial effects of hot‐water extract of SCR against AD are attributed to the additive and/or synergistic effects of some or all of these biologically active constituents, with the relative contribution depending on their potency and abundance in the extract.…”

Section: Discussionmentioning

confidence: 99%

The Hot‐Water Extract of Smilacis Chinae Rhizome Suppresses 2,4‐Dinitrochlorobenzene and House Dust Mite‐Induced Atopic Dermatitis‐Like Skin Lesions in Mice

Park

Sung

et al. 2016

Phytotherapy Research

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Smilacis Chinae Rhizome (SCR) has been used as an oriental folk medicine for various biological activities. However, its effect on atopic dermatitis (AD) remains undetermined to date. We assessed the effect of orally administered hot-water extract of SCR on AD-like skin lesions in mice and its underlying mechanisms. AD-like murine model was prepared by repeated alternate application of house dust mite (Dermatophagoides farinae) extract (DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks, topically to the ears. Daily oral administration of SCR for 3 and 4 weeks significantly reduced inflammatory ear thickening, with the effect being enhanced at the earlier start and longer period of administration. This effect was accompanied by a significant decrease in both Th2 and Th1 serum antibodies (total IgE, DFE-specific IgE, and IgG2a). Histological analysis showed that SCR markedly decreased the epidermal/dermal ear thickening and the dermal infiltration of inflammatory cells. Furthermore, SCR suppressed DFE/DNCB-induced expression of IL-4, IL-13, IL-17, IL-18, TSLP, and IFN-γ genes in the ear tissue. Taken together, our observations demonstrate that chronic oral administration of SCR exerts beneficial effect in mouse AD model, suggesting that SCR has the therapeutic potential as an orally active treatment of AD by modulating both Th1 and Th2 responses.

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Oxyresveratrol ameliorates allergic airway inflammation via attenuation of IL-4, IL-5, and IL-13 expression levels

Cited by 43 publications

References 45 publications

Puerarin alleviates delayed-type hypersensitivity via cytokine inhibition by modulating Th1/Th2 balance

Puerarin alleviates delayed-type hypersensitivity via cytokine inhibition by modulating Th1/Th2 balance

The effects of oxyresveratrol abrogates inflammation and oxidative stress in rat model of spinal cord injury

The Hot‐Water Extract of Smilacis Chinae Rhizome Suppresses 2,4‐Dinitrochlorobenzene and House Dust Mite‐Induced Atopic Dermatitis‐Like Skin Lesions in Mice

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