Oxysophoridine rescues spinal cord injury via anti‑inflammatory, anti‑oxidative stress and anti‑apoptosis effects

Abstract

Oxysophoridine (OSR) is an alkaloid extracted from Sophora alopecuroides L and has various pharmacological activities. The present study aimed to investigate the protective effects and underlying mechanisms of OSR on spinal cord injury (SCI), a clinically common serious trauma, in a rat model. The results of the present study demonstrated that the anti‑inflammatory effect of OSR improved Basso, Beatie and Bresnahan Locomotor Rating Scale scores and reduced spinal cord tissue water contents in an SCI rat model. Inflammatory activation was measured by ELISA, and Prostaglandin E2 (PGE2), intercellular adhesion molecule‑1 (ICAM‑1), cyclooxygenase‑2 (COX‑2), nuclear factor‑κB (NF‑κB) and B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X (Bax) protein expression levels using western blotting. The results revealed that treatment with OSR reduced tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, IL‑8 and malondialdehyde, and increased superoxide dismutase and glutathione peroxidase levels in the serum of an SCI rat model. OSR significantly reduced the protein expression of inflammation‑associated proteins PGE2, ICAM‑1, COX‑2, NF‑κB and Bcl‑2/Bax ratio in the spinal cord tissue of an SCI rat model. Furthermore, the results of the current study demonstrate that OSR ameliorates SCI via anti‑inflammatory, anti‑oxidative stress and anti‑apoptosis effects.

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective

“…Inflammation, apoptosis, and oxidative stress contribute to the secondary damage of SCI [180]. Pharmacological interventions that mitigate the secondary phase process may provide the therapeutic efficacy for SCI [181]. Shi et al indicated that the administration of naringenin ameliorated SCI by down-regulating mir-223, and decreasing tissue myeloperoxidase, as a marker of neutrophil infiltration, as well as abrogating inflammatory cytokines [182].…”

İnguinal herni hastalarında açık mı kapalı teknik mi daha fazla stres yaratır ?

“…Travma sonucu oluşan hücresel zedelenme, serbest radikallerin oluşumunu arttırır [8]. MDA düzeyi, oksidatif stresin bir göstergesi olarak bilinmektedir [4,5,9]. Gal ve arkadaşlarının çalışmasında postoperatif erken dönemde MDA değerleri laparoskopik grupta anlamlı olarak düşük bulunmuştur [4].…”

“…MDA düzeyi, oksidatif stresin bir göstergesi olarak bilinmektedir [4,5,9]. Gal ve arkadaşlarının çalışmasında postoperatif erken dönemde MDA değerleri laparoskopik grupta anlamlı olarak düşük bulunmuştur [4]. Çalışmamızda ise gruplar içinde MDA değerleri açısından anlamlı farklılık bulunmamakla birlikte postoperatif 24. saatteki değerler literatürle uyumlu olarak açık operasyonlarda anlamlı olarak daha yüksekti.…”

“…Travma sonucu oluşan hücresel zedelenme, serbest radikallerin oluşumunu arttırır. Antioksidan bir enzim olan malonilaldehit (MDA) düzeyi oksidatif stresin bir göstergesi olarak bilinmektedir [4,5]. MDA diğer streslerde artış gösterdiği gibi ameliyatın oluşturduğu streste de kanda düzeyi artış gösteren bir parametredir.…”

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

“…Oxysophoridine is an alkaloid extracted from Sophora alopecuroides Linn. Many studies based on in vitro cellular or in vivo animal assays have shown that oxysophoridine has various pharmacological activities, including suppression of the growth of hepatocellular carcinoma [ 10 ] and colorectal cancer cells [ 11 ] by regulating apoptosis associated with the Bcl-2/Bax/caspase-3 signalling pathway, and alleviation of spinal cord injury via anti-inflammatory, anti-oxidative stress and anti-apoptosis effects [ 12 ]. In the present study, we found a new indication for oxysophoridine as a compound inhibiting SARS-CoV-2 infection in cell culture.…”