Oxytetracycline Residue in Striped Bass Muscle

Xu, De‐Hai; Rogers, Wilmer A.

doi:10.1577/1548-8667(1994)006<0349:orisbm>2.3.co;2

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Regardless, Kosoff et al (2007) conducted a study to monitor sulfadimethoxine and ormetoprim residues in Nile Tilapia, Summer Flounder, and Walleyes after administering the standard therapeutic dose for 10 d and found that (1) neither component could be detected in samples of the edible portion of Walleyes (muscle plus skin) collected on day 10 posttreatment or thereafter, (2) only one Summer Flounder had a detectable concentration of either component on day 21 or thereafter, and (3) the elimination of Romet-30 by Nile Tilapia was extremely rapid. Similar results have shown that drug residues accrued after administration of the standard treatment regimen deplete very quickly (i.e., within hours to days) from fish tissues, including blood plasma, kidney, and muscle (e.g., Allen 1988;Xu 1994;Zhang and Li 2007;Bowser et al 2009;Gaikowski et al 2010). The withdrawal period for Romet-30 is as long as 42 d, depending on the use pattern.…”

Section: Myth I: Hatchery Fish Are "Festooned" With Drug Residuessupporting

confidence: 54%

Mythbusters: What's Real and What's Not When It Comes to Fish Drugs

Bowker

Trushenski

2015

N American J Aquac

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Successful fish culture programs take a comprehensive approach to disease management, broodstock conditioning and spawning, marking progeny, and reducing handling stress. Occasionally, drugs are needed to facilitate these tasks, and the only drugs legally available are those that have been approved for such use by the U.S. Food and Drug Administration. A lack of understanding of the approval process and how these products are actually used in fish culture has led to unfounded concerns regarding potential human health issues, unsafe drug residue levels in fish stocked into public waters, and the discharge of elevated concentrations of drugs in hatchery effluents. The rigorous drug approval process requires extensive data to demonstrate that a drug is safe and effective for fish as well as safe to humans and the environment, that it is manufactured and packaged properly, and that it is labeled to avoid misuse. Further, the approval process assumes a naive user and is structured to ensure that, if a drug is approved, even inexperienced personnel could be expected to apply it safely and effectively. If inexperienced personnel can apply these products successfully, experienced fisheries professionals certainly can. In this paper, concerns and misconceptions regarding the drug approval process and use of drugs in fish culture are addressed from a fishery biologist's perspective.

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Section: Myth I: Hatchery Fish Are "Festooned" With Drug Residuessupporting

confidence: 54%

Mythbusters: What's Real and What's Not When It Comes to Fish Drugs

Bowker

Trushenski

2015

N American J Aquac

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“…The elimination half‐life of OTC in E. sinensis was longer than that in fish (Xu & Rogers 1995; Namdari, Abedini & Law 1999; Zhang & Li 2007). Similarly, the elimination half‐lives of OTC in E. sinensis were longer than the corresponding values in M. rosenbergii and Penaeus chinensis (Wang, Lin, Xue & Khalid 2004a; Poapolathep et al.…”

Section: Discussionmentioning

confidence: 92%

Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration

Feng

Gao

et al. 2010

Journal of Fish Diseases

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Crab culture is a very important economic industry in China. An epidemic of tremor disease of Chinese mitten crabs, Eriocheir sinensis, has become a serious problem in recent years. A spiroplasm has been proved to be the causative agent of this disease. Oxytetracycline (OTC) is used widely in aquaculture and was confirmed to be very effective against this pathogen. In this study, the distribution and depletion patterns of OTC in crab muscle were evaluated following single intramuscular doses of 2, 8 and 40 mg kg(-1) body weight. OTC was detected with a validated HPLC method. Concentration-time profiles were well described by a three-compartment model with first-order absorption after a single dose of 8 and 40 mg kg(-1). For comparison, a non-compartment model was employed. A withdrawal time of 48.29 and 55.92 days was suggested prior to consumption after receiving 8 and 40 mg kg(-1). A recommended therapeutic dose of OTC in theory was calculated to be 36.37 mg kg(-1). OTC was distributed well throughout the body. The elimination of OTC in muscle was slower compared with fish and other crustaceans. A dose of 40 mg kg(-1) is suggested for practical use.

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“…After withdrawing OTC in feed, the residues in the muscles were decreased to 37, 10 and 3–7 ng g −1 on 3rd, 7th and 14th days. Xu and Rogers (1994) recommended that by raising fish for 16–24 days at a water temperature of 23°C, OTC could be eliminated from fish muscle. Rigos, Alexis, Andriopoulou and Nengas (2002) showed that OTC is eliminated faster from fish tissue when fish are raised at higher water temperature.…”

Section: Discussionmentioning

confidence: 99%

The fate of chlortetracycline residues in a simulated chicken-fish integrated farming systems

2005

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Two experiments were conducted at the Asian Institute of Technology, Pathumthani, Thailand to investigate the fate of chlortetracycline (CTC) residue in chicken manure and its effect on integrated chicken–fish farming system. During the first experiment, broiler chickens were raised and CTC residues in their manure were analysed. Chicken fed diets containing 0, 50, 200 and 800 CTC mg kg−1 had CTC residue levels of 0, 0.9, 3.8 and 6.5 CTC ng g−1. Once the diet containing CTC was withdrawn, CTC in the manure dropped to negligible amounts (0, 0, 0.2 and 0.5 CTC ng g−1) within 1 day. Integrated chicken–fish farming systems were simulated during the second experiment to determine the fate of antibiotic residues in chicken manure in aquaculture environment. Chickens were fed a CTC‐free diet and a feed containing CTC at 200 mg kg−1. Ten 4 m3 square concrete tanks (2 × 2 × 1 m) were used for the experiment. Five tanks were fertilized with CTC‐contaminated manure and the remaining five tanks were fertilized with CTC‐free manure at a rate of 100 kg dry matter ha−1 day−1. Sex‐reversed Nile tilapia (Oreochromis niloticus) was stocked at 12 fish tank−1 on the 14th day after chicken manure application. The immuno‐radio microbial receptor assay (Charm II test) revealed that edible fish muscle, fish intestinal tract and sediment were contaminated by CTC at rates of 7.21, 22.104 and 1.788 ng g−1, respectively, after 45 days. Chlortetracycline was detected on day 20 in the water column and gradually increased from 0.26 to 12.13 ng g−1. Chlortetracycline residues were not detected in fish or the aquatic environment of the CTC‐free treatment. The results demonstrate the potential for antibiotic residue accumulation in fish and aquatic environment when CTC‐contaminated chicken manure is used for pond fertilization.

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Oxytetracycline Residue in Striped Bass Muscle

Cited by 11 publications

References 14 publications

Mythbusters: What's Real and What's Not When It Comes to Fish Drugs

Mythbusters: What's Real and What's Not When It Comes to Fish Drugs

Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration

The fate of chlortetracycline residues in a simulated chicken-fish integrated farming systems

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