Oxytetracycline Residues in Tissue, Organs, and Eggs of Poultry Fed Supplemented Rations

Katz, Stanley E; Fassbender, Carol A; Dowling, John J

doi:10.1093/jaoac/56.1.77

Cited by 7 publications

(6 citation statements)

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“…Multiple studies [48][49][50][51][52][53][54][55][56][57][58][59][60] have been performed to evaluate depletion of oxytetracycline residues in the eggs of treated hens. In Canada, oxytetracycline soluble powder is approved for use in the drinking water of laying hens at concentrations ranging from 50 to 112 mg/L (190 to 424 mg/gal) with 60-hour to 5-day egg withdrawal intervals, respectively.…”

Section: Farad Poultry Statisticsmentioning

confidence: 99%

Egg residue considerations during the treatment of backyard poultry

Marmulak¹,

Tell²,

Gehring³

et al. 2015

javma

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The purpose of this digest was to provide US veterinarians guidance on the responsible treatment of backyard poultry flocks. The treatment of backyard poultry can be a daunting task for veterinarians because only limited resources are available; however, it is likely to become an increasingly common task owing to the increasing popularity of backyard poultry throughout the United States, especially in urban and suburban areas. Although backyard poultry flock owners may consider their birds pets, the FDA considers them food-producing animals, and veterinarians should follow all regulations that pertain to food-producing animals when administering or prescribing drugs to those birds. The lack of FDA-approved drugs for use in laying hens frequently necessitates the use of drugs in an extralabel manner in backyard poultry. Unfortunately, information regarding the depletion of drug residues in eggs from hens treated with various drugs in an extralabel manner is sparse or lacking, and veterinarians need to be cognizant of this issue, especially when the eggs from treated hens are intended for human consumption.

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Section: Farad Poultry Statisticsmentioning

confidence: 99%

Egg residue considerations during the treatment of backyard poultry

Marmulak¹,

Tell²,

Gehring³

et al. 2015

javma

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“…The low mobility of 15 N-CCC could also be a factor (Bohring, 1972;1982) as it promotes tissue retention of the compound without any metabolism to the other compounds (Bier & Dedek, 1970;1972). Other authors (Katz, et al, 1973;Beale et al, 1990;Shaikh & Chu, 2000;Furusawa et al, 2002) reported varying levels of drug residues in tissues, organs and eggs of poultry at different days after drug withdrawal. The residue levels were attributed to the body fat content that affects drug release back into the blood.…”

Section: Resultsmentioning

confidence: 99%

Chlorocholine chloride residue distribution in eggs, breast and femur meat of laying hens determined by labelled-<sup>15</sup>N estimates

Kabasa¹,

Thinggaard²,

Meulen³

2004

SA J. An. Sci.

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The distribution of chlorocholine chloride (CCC) residue or its metabolites in the meat and eggs of laying hens was studied using the 15 N delta value (δ 15 N) and 15 N atom % derived from 15 N-CCC containing diets. In a completely randomised design, 20 laying hens were divided into four groups allocated four different diets namely; 0 mg 15 N-CCC /kg feed a control diet (group A); 5 mg 15 N-CCC /kg feed (group B), 50 mg 15 N-CCC /kg (group C) and 100 mg 15 N-CCC /kg (group D) for 11 days. During the seven days that followed, 15 N-CCC diets were withdrawn and all hens were restored to feeding on the control diet. The δ 15 N excess and 15 N atom % excess in meat and eggs of hens fed diets containing 15 N-CCC, were higher than in the control diet after 11 days of treatment and seven days after withdrawal of 15 N-CCC, except for the egg yolk values of hens fed 5 mg 15 N-CCC /kg feed. The δ 15 N excess and 15 N atom % excess of meat, egg yolk and egg albumen were dependent on dietary 15 N-CCC concentrations and differed significantly between tissues for each of the three 15 N-CCC concentrations examined. Femur meat δ 15 N excess and 15 N atom % excess were similar to that of breast meat but differed significantly from that of other tissues. The results show that tissue type is a factor in CCC residue/metabolite accumulation in chicken products suggesting differences in exposure or risk of CCC on consumers.

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“…Finally, there is very little is known about the partitioning of these antimicrobial drugs into the various milk fractions (e. g., whey proteins, butter fat) following processing and whether cooking can influence the stability of these antimicrobials. Older studies have reported that chlortetracycline can be converted to isochlortetracyline which lacks sensitizing properties (Shirk et al, 1956) and that oxytetracyline is converted to α and βapooxytetracylines (Katz et al, 1973) which may reduce the risk to adverse health effects to tetraccylines.…”

Section: Risk Managementmentioning

confidence: 99%

Health concerns and management of select veterinary drug residues

Baynes

DeDonder

Kissell

et al. 2016

Food and Chemical Toxicology

240

131

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The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals. Our other objectives are to briefly inform the reader of why many of these drugs are or were approved for use in livestock production and how drug residues can be mitigated for these drugs. The selected drugs include several antimicrobials, beta agonists, and phenylbutazone. The antimicrobials continue to be of regulatory concern not only because of their acute adverse effects but also because their use as growth promoters have been linked to antimicrobial resistance. Furthermore, nitroimidazoles and arsenicals are no longer approved for use in food animals in most jurisdictions. In recent years, the risk assessment and risk management of beta agonists, have been the focus of national and international agencies and this manuscript attempts to review the pharmacology of these drugs and regulatory challenges. Several of the drugs selected for this review can cause noncancer effects (e.g., penicillins) and others are potential carcinogens (e.g., nitroimidazoles). This review also focuses on how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments.

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Oxytetracycline Residues in Tissue, Organs, and Eggs of Poultry Fed Supplemented Rations

Cited by 7 publications

References 0 publications

Egg residue considerations during the treatment of backyard poultry

Egg residue considerations during the treatment of backyard poultry

Chlorocholine chloride residue distribution in eggs, breast and femur meat of laying hens determined by labelled-<sup>15</sup>N estimates

Health concerns and management of select veterinary drug residues

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