Oxytocin, a main breastfeeding hormone, prevents hypertension acquired in utero: A therapeutics preview

Vargas-Martínez, Froylán; Schanler, Richard J.; Abrams, Steven A.; Hawthorne, Keli M.; Landers, Susan; Guzmán-Bárcenas, José; Muñoz, Onofre; Henriksen, Tore; Petersson, Maria; Uvnäs‐Moberg, Kerstin; Jiménez‐Estrada, Ismael

doi:10.1016/j.bbagen.2016.09.020

Cited by 6 publications

(3 citation statements)

References 175 publications

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“…Oxytocin is deeply involved in body defense against hypertension. As reported, intrauterine growth restriction, caused by excessive glucocorticoid exposure to the fetus, produced hypertension later in life due to damages to OTR signaling (Vargas-Martinez et al, 2017). In hypertensive rats, a decreased expression of OT mRNA and protein was found in hypothalamus.…”

Section: Mechanisms Underlying the Protective Effects Of Otmentioning

confidence: 81%

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

Wang

Yang

et al. 2019

Front. Neurosci.

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Coronary artery disease (CAD) is a major cardiovascular disease responsible for high morbidity and mortality worldwide. The major pathophysiological basis of CAD is atherosclerosis in association with varieties of immunometabolic disorders that can suppress oxytocin (OT) receptor (OTR) signaling in the cardiovascular system (CVS). By contrast, OT not only maintains cardiovascular integrity but also has the potential to suppress and even reverse atherosclerotic alterations and CAD. These protective effects of OT are associated with its protection of the heart and blood vessels from immunometabolic injuries and the resultant inflammation and apoptosis through both peripheral and central approaches. As a result, OT can decelerate the progression of atherosclerosis and facilitate the recovery of CVS from these injuries. At the cellular level, the protective effect of OT on CVS involves a broad array of OTR signaling events. These signals mainly belong to the reperfusion injury salvage kinase pathway that is composed of phosphatidylinositol 3-kinase-Akt-endothelial nitric oxide synthase cascades and extracellular signal-regulated protein kinase 1/2. Additionally, AMP-activated protein kinase, Ca 2+ /calmodulin-dependent protein kinase signaling and many others are also implicated in OTR signaling in the CVS protection. These signaling events interact coordinately at many levels to suppress the production of inflammatory cytokines and the activation of apoptotic pathways. A particular target of these signaling events is endoplasmic reticulum (ER) stress and mitochondrial oxidative stress that interact through mitochondria-associated ER membrane. In contrast to these protective effects and machineries, rare but serious cardiovascular disturbances were also reported in labor induction and animal studies including hypotension, reflexive tachycardia, coronary spasm or thrombosis and allergy. Here, we review our current understanding of the protective effect of OT against varieties of atherosclerotic etiologies as well as the approaches and underlying mechanisms of these effects. Moreover, potential cardiovascular disturbances following OT application are also discussed to avoid unwanted effects in clinical trials of OT usages.

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Section: Mechanisms Underlying the Protective Effects Of Otmentioning

confidence: 81%

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

Wang

Yang

et al. 2019

Front. Neurosci.

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“…Oxytocin exerts diverse central and peripheral effects, though the most known and established roles are stimulating uterine contractions during childbirth and milk production during lactation (Augustine et al, 2018). Oxytocin is also involved in cardiovascular regulation and various stress-related neuropsychiatric disorders (Vargas-Martínez et al, 2017, Iovino et al, 2018). Oxytocin peptide mRNA was significantly elevated in the prefrontal cortex of male subjects with alcohol use disorder compared to controls, using post-mortem brain tissue (Lee et al, 2017b).…”

Section: Discussionmentioning

confidence: 99%

GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network

Xiang

Yang

Zhou

et al. 2018

American J of Med Genetics Pt B

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Alcohol dependence (AD) and nicotine dependence (ND) co-occur frequently (AD+ND). We integrated SNP-based, gene-based, and protein-protein interaction (PPI) network analyses to identify shared risk genes or gene subnetworks for AD+ND in African Americans (AAs, N=2094) and European Americans (EAs, N=1207). The DSM-IV criterion counts for AD and ND were modeled as two dependent variables in a multivariate linear mixed model, and analyzed separately for the two populations. The most significant SNP was rs6579845 in EAs (p<1.29×10−8) in GM2A, which encodes GM2 ganglioside activator, and is a cis-expression quantitative locus (eQTL) that affects GM2A expression in blood and brain tissues. However, this SNP was not replicated in another small sample. We identified a subnetwork of 24 genes that contributed to the AD+ND criterion counts. In the gene-set analysis for the subnetwork in an independent sample, the Study of Addiction: Genetics and Environment project (SAGE) (predominately EAs), these 24 genes as a set differed in AD+ND versus control subjects in EAs (p=0.041). Functional enrichment analysis for this subnetwork revealed that the gene enrichment involved primarily nerve growth factor pathways, and cocaine and amphetamine addiction. In conclusion, we identified a genomewide significant variant at GM2A and a gene subnetwork underlying the genetic trait of shared AD+ND. These results increase our understanding of the shared (pleiotropic) genetic risk that underlies AD+ND.

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“…Increased plasma oxytocin has also been linked to an increased risk of pregnancy-induced hypertension[ 14 ], and exogenous oxytocin administration has been associated with angiotensin II-induced hypertension[ 15 ]. Interestingly, though, there is also a potential link between increased oxytocin and reduced risk of hypertension (which might be acquired in utero in association with intrauterine growth retardation)[ 16 ], so that oxytocin has been attributed with eliciting a reduction in blood pressure[ 17 , 18 ].…”

Section: Physiological Functions Of Oxytocinmentioning

confidence: 99%

Oxytocin and cancer: An emerging link

Lerman¹,

Harricharran²,

Ogunwobi³

2018

WJCO

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The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker. This review summarizes observations linking oxytocin and cancer, with a special emphasis on prostate cancer, where it may promote cell proliferation. Research suggests that oxytocin effects may depend on cell type, concentration of the hormone, its interactions with other hormones in the microenvironment, and the precise localization of its receptor on the cell membrane. Future research is needed to further elucidate the involvement of oxytocin in cancer, and whether it could be a clinical cancer biomarker or therapeutic target.

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Oxytocin, a main breastfeeding hormone, prevents hypertension acquired in utero: A therapeutics preview

Cited by 6 publications

References 175 publications

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network

Oxytocin and cancer: An emerging link

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