Oxytocin and Anxiety Disorders

Gottschalk, Michael G.; Domschke, Katharina

doi:10.1007/7854_2017_25

Cited by 50 publications

(34 citation statements)

References 167 publications

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“…OT has been proposed to be a promising treatment for several psychiatric disorders including substance abuse, autism spectrum disorders, anxiety, stress-related disorders, and schizophrenia [168][169][170][171][172]. If the inverted U hypothesis of a sex-dependent relationship between OT dose and its effects on social reward (and perhaps other factors important in the etiology of mental disorders) is correct, then consideration of gender differences in OT administration will be particularly important.…”

Section: Synthesismentioning

confidence: 99%

Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

Borland

Rilling

Frantz

et al. 2018

Neuropsychopharmacol

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The rewarding properties of social interactions are essential for the expression of social behavior and the development of adaptive social relationships. Here, we review sex differences in social reward, and more specifically, how oxytocin (OT) acts in the mesolimbic dopamine system (MDS) to mediate the rewarding properties of social interactions in a sex-dependent manner. Evidence from rodents and humans suggests that same-sex social interactions may be more rewarding in females than in males. We propose that there is an inverted U relationship between OT dose, social reward, and neural activity within structures of the MDS in both males and females, and that this dose-response relationship is initiated at lower doses in females than males. As a result, depending on the dose of OT administered, OT could reduce social reward in females, while enhancing it in males. Sex differences in the neural mechanisms regulating social reward may contribute to sex differences in the incidence of a large number of psychiatric and neurodevelopmental disorders. This review addresses the potential significance of a sex-dependent inverted U dose-response function for OT's effects on social reward and in the development of gender-specific therapies for these disorders.

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Section: Synthesismentioning

confidence: 99%

Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

Borland

Rilling

Frantz

et al. 2018

Neuropsychopharmacol

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“…In addition, neuroticism not only predicts psychopathology over time (Kendall et al, 2015), but it's also associated with negative interpersonal outcomes such as increased reactivity to stressful events following conflict (Suls et al, 1998), a tendency to use negative forms of coping following interpersonal stress (Gunthert et al, 1999), and negative marital outcomes including divorce (Kelly and Conley, 1987). As studies continue to elucidate potential relationships between oxytocin and psychopathology (McQuaid et al, 2014;Gottschalk and Domschke, 2018), the present results suggest that neuroticism should be a target of future oxytocin research. This enhanced focus on neuroticism The addition of robustness covariates or their interactions did not alter the significance of the primary interaction effects or the significance of simple slopes.…”

Section: Discussionmentioning

confidence: 72%

Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity

et al. 2020

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CD38 genetic variation has been associated with autism spectrum disorders and social anxiety disorder, which may result from CD38's regulation of oxytocin secretion. Converging evidence has found that the rs3796863 A-allele contributes to increased social sensitivity compared to the CC genotype. The current study examined the moderating role of CD38 genetic variants (rs3796863 and rs6449182) that have been associated with enhanced (or reduced) social sensitivity on neural activation related to neuroticism, which is commonly elevated in individuals with social anxiety and depression. Adults (n = 72) with varying levels of social anxiety and depression provided biological samples for DNA extraction, completed a measure of neuroticism, and participated in a standardized emotion processing task (affect matching) while undergoing fMRI. A significant interaction effect was found for rs3796863 x neuroticism that predicted right amygdala-subgenual anterior cingulate cortex (sgACC) functional connectivity. Simple slopes analyses showed a positive association between neuroticism and right amygdala-sgACC connectivity among rs3796863 A-allele carriers. Findings suggest that the more socially sensitive rs3796863 A-allele may partially explain the relationship between a known risk factor (i.e., neuroticism) and promising biomarker (i.e., amygdala-sgACC connectivity) in the development and maintenance of social anxiety and depression.

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“…It could help to diagnose deficits or asymmetries of trust between partners, monitor the effects of therapeutic interventions, or help to initiate constructive communication on relationship-relevant issues presented in the TGC items (for research on the importance of communication in romantic relationships, see [48][49][50][51]). One could further identify dysfunctional trust in relationships in case of one partner or both partners suffering from a mental disorder that hampers the development of interpersonal trust (e.g., separation anxiety; [52]). Moreover, the TGC enables researchers to investigate experimental manipulations of various social contexts (e.g., couple conflict; [53,54]) and trust-related hormones (e.g., oxytocin; [8]) on partner-specific trust.…”

Section: Plos Onementioning

confidence: 99%

The Trust Game for Couples (TGC): A new standardized paradigm to assess trust in romantic relationships

et al. 2020

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Trust between couples is a prerequisite for stable and satisfactory romantic relationships. However, there has been no valid research tool to assess partner-specific trust behavior including costly investments in the trustworthiness of the romantic partner. We here present a comprehensive validation of the newly developed Trust Game for Couples (TGC) by means of various self-report and implicit relationship-related measures. The TGC operationalizes trust by measuring an individual's willingness to invest his or her own financial resources in pro-relationship attitudes of their romantic partner (collected by dichotomous responses to relationship-relevant items, e.g., answering yes to "I am absolutely sure that I love my partner"). Thirty-five healthy couples between 20 and 34 years completed the TGC in an interactive (both partners present), but anonymous setting (no information on the partner's responses revealed). Trust, as measured by the TGC, correlates positively with selfreported trust, satisfaction, and felt closeness in the relationship, but not with general interpersonal trust, confirming both its convergent and discriminant validity. In addition to explicit criteria for construct validity, implicit measures of partner valence and confidence explained variance in the TGC, demonstrating that it constitutes an economical measure of implicit and explicit ingredients of trust between couples. In sum, the TGC provides a novel, specific behavioral tool for a sensitive assessment of trust in dyadic relationships with potential for numerous research fields.

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Oxytocin and Anxiety Disorders

Cited by 50 publications

References 167 publications

Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity

The Trust Game for Couples (TGC): A new standardized paradigm to assess trust in romantic relationships

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