Oxytocin and social context moderate social support seeking in women during negative memory recall

Cardoso, Christopher; Valkanas, Helen; Serravalle, Lisa; Ellenbogen, Mark A.

doi:10.1016/j.psyneuen.2016.05.001

Cited by 23 publications

(20 citation statements)

References 30 publications

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“…Our findings provide insight in the neurobiological mechanisms underlying the previously observed effects of oxytocin on social approach behavior (Harari-Dahan and Bernstein, 2014; Preckel et al , 2014; Auyeung et al , 2015), trust (Bakermans-Kranenburg and van I Jzendoorn 2013) and social support (Heinrichs et al , 2003; Cardoso et al , 2016). More importantly however, our findings specifically support the hypothesis that intranasal oxytocin administration can enhance neural sensitivity to social reward in PTSD patients, which could potentially increase treatment response by applying oxytocin in addition to psychotherapy (MEP).…”

Section: Discussionmentioning

confidence: 52%

“…A meta-analysis showed that in healthy individuals oxytocin increases (in-group) trust (Van IJzendoorn and Bakermans-Kranenburg, 2012). Also, intranasal oxytocin increased social approach behavior, such as reduced social distance between participants and the experimenter (Preckel et al , 2014), increased feelings of social support during recall of negative memories (Cardoso et al , 2016), and increased eye contact with the experimenter (Auyeung et al , 2015). Furthermore, oxytocin increased the ability to benefit from social support during stressful situations (Heinrichs et al , 2003).…”

Section: Introductionmentioning

confidence: 99%

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Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder

Nawijn

Zuiden

Koch

et al. 2016

Social Cognitive and Affective Neuroscience

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Therapeutic alliance and perceived social support are important predictors of treatment response for post-traumatic stress disorder (PTSD). Intranasal oxytocin administration may enhance treatment response by increasing sensitivity for social reward and thereby therapeutic alliance and perceived social support. As a first step to investigate this therapeutical potential, we investigated whether intranasal oxytocin enhances neural sensitivity to social reward in PTSD patients. Male and female police officers with (n = 35) and without PTSD (n = 37) were included in a double-blind, randomized, placebo-controlled cross-over fMRI study. After intranasal oxytocin (40 IU) and placebo administration, a social incentive delay task was conducted to investigate neural responses during social reward and punishment anticipation and feedback. Under placebo, PTSD patients showed reduced left anterior insula (AI) responses to social rewards (i.e. happy faces) compared with controls. Oxytocin administration increased left AI responses during social reward in PTSD patients, such that PTSD patients no longer differed from controls under placebo. Furthermore, in PTSD patients, oxytocin increased responses to social reward in the right putamen. By normalizing abberant insula responses and increasing putamen responses to social reward, oxytocin administration may enhance sensitivity for social support and therapeutic alliance in PTSD patients. Future studies are needed to investigate clinical effects of oxytocin.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder

Nawijn

Zuiden

Koch

et al. 2016

Social Cognitive and Affective Neuroscience

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“…Repeated oxytocin administration may have increased social support seeking behaviour (Cardoso, Valkanas, Serravalle, & Ellenbogen, 2016; Preckel et al, 2014) – potentially by affecting neural reward functioning (Groppe et al, 2013; e.g. Nawijn et al, 2016a, 2016b) – or may have affected autonomic or glucocorticoid stress reactivity (Cohen et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals

Frijling

2017

European Journal of Psychotraumatology

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Background: Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which develops in approximately 10% of trauma-exposed individuals. Currently, there are few early preventive interventions available for PTSD. Intranasal oxytocin administration early posttrauma may prevent PTSD symptom development, as oxytocin administration was previously found to beneficially impact neurobiological (e.g. amygdala reactivity) and socio-emotional PTSD vulnerability factors. Objective: The overall aim of this dissertation was to investigate the potential of intranasal oxytocin administration as early preventive intervention for PTSD. Methods: We performed a functional magnetic resonance imaging (fMRI) study to assess the acute effects of a single administration of oxytocin on the functional fear neurocircuitry – consisting of the amygdala and (pre)frontal brain regions – in recently trauma-exposed emergency department patients (range n = 37–41). In addition, we performed a multicentre randomized double-blind placebo-controlled clinical trial (RCT) to assess the efficacy of repeated intranasal oxytocin administration early after trauma for preventing PTSD symptom development up to six months posttrauma (n = 107). Results: In our fMRI experiments we observed acutely increased amygdala reactivity to fearful faces and attenuated amygdala-ventromedial and ventrolateral prefrontal cortex functional connectivity after a single oxytocin administration in recently trauma-exposed individuals. However, in our RCT we found that repeated intranasal oxytocin administration early posttrauma reduced subsequent PTSD symptom development in recently trauma-exposed emergency department patients with high acute PTSD symptoms. Conclusions: These findings indicate that repeated intranasal oxytocin is a promising early preventive intervention for PTSD for individuals at increased risk for PTSD due to high acute symptom severity. Administration frequency dependent effects of oxytocin or the effects of oxytocin administration on salience processing may serve as explanatory frameworks for the contrasting oxytocin effects on anxiety-related measures in our clinical and neuroimaging studies.

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“…The interaction of oxytocin and social support had more prominent effects to suppress the stress-induced cortisol response and anxiety than social support or oxytocin alone [24]. In contrast, a negative or null effect was observed while the administration of oxytocin was in a negative or non-social context [38–40]. In sum, the effects of oxytocin are social environment dependent [13] and vary in different level of social support.…”

Section: Discussionmentioning

confidence: 99%

The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression

Tsai

Tseng

Hung

et al. 2019

Clin Psychopharmacol Neurosci

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ObjectiveLoneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness and hypothalamic-pituitary-adrenal (HPA)-axis activity in drug-naïve patients with major depressive disorder (MDD).MethodsTwenty-six patients with MDD (male:female = 3:23; mean age, 45.54 ± 12.97 years) were recruited. The 17-item Hamilton Depression Rating Scale, UCLA Loneliness Scale and self-reported Measurement of Support Function Questionnaire were administered. Serum oxytocin and cortisol levels were assessed using a commercial immunoassay kits.ResultsIn MDD patients, a negative association was found between degrees of social support and loneliness (β = −0.39, p = 0.04). The interaction between social support and serum oxytocin level was negatively associated with loneliness (β = −0.50, p = 0.017) and serum cortisol level (β = −0.55, p = 0.020) after adjusting for age. Follow-up analyses showed that the association between higher social support and lower loneliness was observed only in the higher-oxytocin group (r = −0.75, p = 0.003) but not in the lower group (r = −0.19, p = 0.53). The significance remained after further adjusting for sex and depression severity.ConclusionLow oxytocin level is a vulnerability factor for the buffering effect of social support for loneliness and aberrant HPA-axis activity in MDD patients.

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Oxytocin and social context moderate social support seeking in women during negative memory recall

Cited by 23 publications

References 30 publications

Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder

Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder

Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals

The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression

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