Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types

Wrobel, Ludovic J.; Reymond-Marron, I.; Dupré, Anouk; Raggenbass, Mario

doi:10.1016/j.neuroscience.2009.11.001

Cited by 26 publications

(20 citation statements)

References 33 publications

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“…ParvOT neurones have been implicated to orchestrate and control the activity of magnOT cells via PVN‐SON connections. The OTR is expressed in many different cells throughout the brain and, in most cases, OTR distribution could be matched with OT‐ergic projections in rodents and primates in the periaqueductal grey, hypoglossal nucleus of the medulla, brainstem, NTS and spinal cord . However, it is not clear whether these parvOT projections are terminating exclusively in the respective brain regions or whether they are simultaneously projecting to other brain regions by forming collaterals.…”

Section: Parvocellular Ot Cellsmentioning

confidence: 99%

“…Out of 2417 ± 69.5 OT neurones counted, only 71 ± 9.5 cells were Fluorogold‐negative, indicating that approximately 3% of all OT neurones in the PVN are parvOT cells. Considering the discrepancy between the relative low number of parvOT neurones and the strong innervation of various hindbrain areas, it is tempting to propose that parvOT neurones form multiple collaterals and project to several hindbrain regions simultaneously.…”

Section: Discrimination Between Ot Cell Typesmentioning

confidence: 99%

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Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?

Althammer

Grinevich

2018

J Neuroendocrinology

110

123

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The hypothalamic neuropeptide oxytocin (OT), which is evolutionarily conserved among different species throughout the animal kingdom, is a key modulator of a variety of socio-emotional behaviors such as fear, trust and empathy. OT cells in the mammalian hypothalamus have been traditionally divided into two distinct typesmagnocellular (magnOT) and parvocellular (parvOT) or preautonomic neurons. This distinction is based on OT cell sizes and shapes, projections, electrophysiological activity and functions. Indeed, while neuroendocrine magnOT neurons are known to primarily project their axons to the posterior pituitary and to a number of forebrain Accepted Article Accepted ArticleThis article is protected by copyright. All rights reserved. Furthermore, unexpected axonal projections of parvOT neurons to the forebrain and magnOT neurons to the midbrain have been newly reported. In this review, we focus on the detailed analysis of methods of distinction between OT cell types, in-and output sites, morphology as well as on the direct connectivity between OT neurons and its physiological significance. At the end, we propose a hypothesis that the central OT system is composed of more than just two OT cell types, which should be further verified by the application of available genetic and anatomical techniques.

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Section: Parvocellular Ot Cellsmentioning

confidence: 99%

Section: Discrimination Between Ot Cell Typesmentioning

confidence: 99%

Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?

Althammer

Grinevich

2018

J Neuroendocrinology

110

123

View full text Add to dashboard Cite

show abstract

“…Spontaneous synaptic events were automatically screened with a current threshold of 15 pA. Then, the detected synaptic events were visually inspected for acceptance or rejection based on the rise and decay times; the rise time was 10–90%, and the decay time was measured from the peak amplitude by fitting with a single exponential function. As the amplitudes of IPSCs were distributed log‐normally, the mean (μ) and standard deviation (σ) of the amplitudes were calculated using the following equations: μ = exp( M + S 2 /2) and σ 2 = exp(2 M + 2 S 2 ) − exp(2 M + S 2 ), where M and S are the mean and standard deviation of the normally distributed log‐transformed amplitudes, respectively (Hirasawa et al ., ; Liu et al ., ; Reymond‐Marron et al ., ; Wrobel et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature‐sensitive and temperature‐insensitive neurons in the rat preoptic area

Sun

et al. 2018

Eur J of Neuroscience

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The preoptic area (POA) of the hypothalamus, containing temperature-sensitive and temperature-insensitive neurons, plays a key role in specific thermoregulatory responses. Although arginine vasopressin (AVP) has been shown to induce hypothermia by increasing the firing activities of warm-sensitive neurons and decreasing those of cold-sensitive and temperature-insensitive neurons, the effects of AVP on POA GABAergic transmission remain unknown. Herein, inhibitory postsynaptic currents (IPSCs) of temperature-sensitive and temperature-insensitive neurons in POA slices were recorded using whole-cell patch clamp. By monitoring changes in GABAergic transmission during AVP treatment, we showed that AVP decreased the amplitudes and frequencies of spontaneous IPSCs in mostly warm-sensitive neurons and in some temperature-insensitive neurons but increased these parameters in other temperature-insensitive neurons. The IPSC amplitude was reduced for only cold-sensitive neurons. RT-PCR and Western blot analyses further confirmed the POA expression of V1a receptors and GABA receptors, including the subunits α1, α2, α3, β2, β3 and γ2. The effects of AVP on IPSCs in temperature-sensitive and temperature-insensitive neurons were dependent on G proteins and intracellular Ca . AVP-mediated modulation was associated with changes in the kinetic parameters (decay time, 10-90% rise time, half-width). Together, these results suggest that AVP, acting via V1a receptors but not V1b receptors, differentially modulates GABAergic synaptic transmission and fine-tunes the firing activities of temperature-sensitive and temperature-insensitive neurons in the rat POA.

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“…TRH depolarized 12N neurons, increased spontaneous activity, and potentiated responses evoked by iontophoresis of NMDA (Rekling, 1990(Rekling, , 1992. Both oxytocin and vasopressin also modulate 12N activity, but this is likely due to receptors on nearby pre-hypoglossal neurons rather than on axonal projections (Wrobel et al, 2010). Immunohistochemical labeling for another neuromodulator, adenosine deaminase was restricted to the dorsal division of 12N (Senba et al, 1987a) but was transient, disappearing by postnatal day 25.…”

Section: Brainstem and Cerebellummentioning

confidence: 96%

Oromotor Nuclei

Travers

2015

The Rat Nervous System

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Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types

Cited by 26 publications

References 33 publications

Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?

Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?

Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature‐sensitive and temperature‐insensitive neurons in the rat preoptic area

Oromotor Nuclei

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