Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach

Wade, Mark; Hoffmann, Thomas J.; Knafo‐Noam, Ariel; O’Connor, Thomas G.; Jenkins, Jennifer M.

doi:10.1016/j.yhbeh.2016.05.002

Cited by 4 publications

(11 citation statements)

References 82 publications

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“…However, contrary to expectation, there was no evidence of an interaction with maternal CM. In line with our results, previous results indicated that the rs2740210 polymorphism was associated with externalizing psychiatric symptoms in children ( Wade et al, 2016 ). However, the study only investigated children and therefore it could not be determined if the effect was moderated by early adverse maternal experiences.…”

Section: Discussionsupporting

confidence: 93%

“…Previous research in children further revealed that the rs2740210 polymorphism is related to children's psychological development (Wade et al, 2016;Smarius et al, 2020). In a study with 320 pre-school aged children, a two-marker OXT haplotype, including the rs2740210 SNP, was associated with the amount of externalizing symptoms (Wade et al, 2016). Prospective research showed that children carrying the C (risk) allele were more likely to develop general anxiety symptoms at the age of 5-6 and emotional symptoms at the age of 11-12 when exposed to maternal verbal aggressive behavior in the 13th postnatal week (Smarius et al, 2020).…”

Section: Intergenerational Cycle Of Maltreatment and Child Biological...mentioning

confidence: 99%

“…Studies showed that the interaction affected breastfeeding duration ( Jonas et al, 2013 ) and the quality of maternal care independently and in interaction with negative early life experiences ( Mileva-Seitz et al, 2013 ). Previous research in children further revealed that the rs2740210 polymorphism is related to children’s psychological development ( Wade et al, 2016 ; Smarius et al, 2020 ). In a study with 320 pre-school aged children, a two-marker OXT haplotype, including the rs2740210 SNP, was associated with the amount of externalizing symptoms ( Wade et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

Buchheim

Ziegenhain

Kindler

et al. 2022

Front. Hum. Neurosci.

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IntroductionChildhood maltreatment (CM) is a developmental risk factor and can negatively influence later psychological functioning, health, and development in the next generation. A comprehensive understanding of the biopsychosocial underpinnings of CM transmission would allow to identify protective factors that could disrupt the intergenerational CM risk cycle. This study examined the consequences of maternal CM and the effects of psychosocial and biological resilience factors on child attachment and stress-regulatory development using a prospective trans-disciplinary approach.MethodsMother-child dyads (N = 158) participated shortly after parturition (t0), after 3 months (t1), and 12 months later (t2). Mothers’ CM experiences were assessed at t0, attachment representation at t1 and psychosocial risk and social support were assessed at t1 and t2. At t2, dyads participated in the Strange Situation Procedure (SSP). Children’s attachmen status were classified as organized vs. disorganized, including their level of disorganized behavior, and heart rate (HR) and respiratory sinus arrhythmia (RSA) were recorded as stress response measures of the autonomic nervous system. Maternal caregiving during SSP was assessed using the AMBIANCE scale. Child’s single nucleotide polymorphisms rs2254298 within the oxytocin receptor (OXTR) and rs2740210 of the oxytocin gene (OXT) were genotyped using DNA isolated from cord blood.ResultsMaternal CM experiences (CM+) were significantly associated with an unresolved attachment status, higher perceived stress and more psychological symptoms. These negative effects of CM were attenuated by social support. As expected, maternal unresolved attachment and child disorganized attachment were significantly associated. Maternal caregiving did not mediate the relationship between maternal and child attachment but influenced children’s HR and RSA response and disorganized behavior. Moreover, the rs2254298 genotype of the OXTR gene moderated the stress response of children from mothers with CM. Children carrying the rs2740210 risk allele of the OXT gene showed more disorganized behavior independent from maternal CM experiences.ConclusionWe replicated and extended existing CM and attachment models by co-examining maternal attachment, social support, and child genetic susceptibility on child attachment and cardiovascular stress regulation. The findings contribute to an extended understanding of risk and resilience factors and enable professionals to target adequate services to parents and children at risk.

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Section: Discussionsupporting

confidence: 93%

Section: Intergenerational Cycle Of Maltreatment and Child Biological...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

Buchheim

Ziegenhain

Kindler

et al. 2022

Front. Hum. Neurosci.

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“…The dopamine D4 receptor gene ( DRD4 ) [ 69 , 70 , 71 , 72 , 73 ]; the dopamine reuptake transporter polymorphisms in the 3′ UTR ( DAT1 ) [ 70 , 72 , 73 ]; Zinc-finger protein gene polymorphism rs1344706 ( ZNF804A ) [ 74 , 75 ]; the catechol-O-methyltransferase enzyme gene polymorphism Val158Met ( COMT ) [ 70 , 71 , 73 , 76 ]; the serotonin carrier gene polymorphism 5-HTTLPR ( SCL6A4 ) [ 73 , 77 ]; the oxytocin receptor gene polymorphisms ( OXTR ) and the oxytocin gene polymorphisms ( OXT ) [ 71 , 78 , 79 , 80 , 81 , 82 , 83 ]; the arginine vasopressin hormonal genes polymorphisms ( AVP ) and the arginine vasopressin subtype 1A receptor gene polymorphisms ( AVPR1A ) [ 79 , 84 ]; other polymorphisms including the ones belonging to MAO-A genes, EFHC2 genes, and GTF2I genes [ 85 , 86 , 87 ].…”

Section: Resultsmentioning

confidence: 99%

Theory of Mind: A Brief Review of Candidate Genes

Silvestri,

Scaini,

Giani

et al. 2024

Genes

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Deficits in theory of mind (ToM), known as the ability to understand the other’s mind, have been associated with several psychopathological outcomes. The present systematic review aims to summarize the results of genetic studies that investigated gene polymorphisms associated with mentalization performance tasks in children and adults. The systematic review was carried out following PRISMA guidelines, and the literature search was conducted in PubMed and EBSCOhost using the following keywords: ‘theory of mind, mentalizing, mindreading’ and ‘gene, genetic basis’. Nineteen studies met the eligibility criteria for inclusion. Most of the literature focused on the role of DRD4, DAT1, OXTR, OXT, COMT, ZNF804A, AVP, AVPR, SCL6A4, EFHC2, MAO-A, and the family of GTF2I genes in influencing ToM. However, controversial results emerged in sustaining the link between specific genetic polymorphisms and mentalization abilities in children and adults. Available data show heterogeneous outcomes, with studies reporting an association between the same family genes in subjects of the same age and other studies reporting no correlation. This does not allow us to draw any solid conclusions but paves the way for exploring genes involved in ToM tasks.

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“…Os instrumentos de avaliação dos comportamentos (SDQ e CBCL) foram aplicados para confirmar as crianças do grupo clínico, visto que apenas a identificação pelos professores ou pais poderia implicar no viés de avaliação, ou mesmo para os casos em que a criança fosse novata na escola e os professores não tivessem conhecimento sobre os comportamentos dela (Jones et al, 2013;Boxmeyer et al, 2021;Wade et al, 2016). Além disso, buscou-se assegurar que as crianças do grupo controle não apresentavam problemas de comportamento externalizante.…”

Section: Confirmação Do Grupo Clínicounclassified

Relação entre cognição social e pró-socialidade em crianças com problemas de comportamento externalizante

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AGRADECIMENTOSA Deus, ao Universo, a Vida! À minha perfeita orientadora, Profa. Betânia Alves Veiga Dell'Agli, pelos ensinamentos, pelo acolhimento e apoio durante a minha jornada na Pós-Graduação. Aprendi com você para além da dimensão acadêmica, sua sensibilidade e acolhimento me ensinaram mais do que livros e artigos são capazes. Você tem minha gratidão e respeito.À profa. Luciana Maria Caetano, que junto com minha orientadora me ajudou a ser uma melhor pesquisadora e pessoa. Luciana, você foi a primeira a acreditar em mim, ainda na entrevista de seleção, e desde então nunca me deixou sozinha. Obrigada por tudo que fez e vem fazendo em prol dos seus "filhos" e "filhas" do GPDM.Aos funcionários do Instituto de Psicologia da USP, em especial ao Gustavo Carneiro da Silva, que sempre foi atencioso e solícito, me ajudando mais vezes do que ele pode imaginar.

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Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach

Cited by 4 publications

References 82 publications

Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

Theory of Mind: A Brief Review of Candidate Genes

Relação entre cognição social e pró-socialidade em crianças com problemas de comportamento externalizante

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