Oxytocin is expressed throughout the human gastrointestinal tract

Ohlsson, Bodil; Truedsson, Mikael; Djerf, Pauline; Sundler, F.

doi:10.1016/j.regpep.2006.03.008

Cited by 86 publications

(95 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The unique Met-enkephalin (OGF)-induced functions have led to the proposal that Met-enkephalin (OGF) may best be considered to be one of the cytokines of the immune system [27] . As our biopsies have been used for immunohistochemical analyses [28] , we have seen that there is very sparse expression of immune cells in the various tissues, which excludes the possibility that the proenkephalin-A mRNA expression observed in this study may originate from immune cells.…”

Section: Discussionmentioning

confidence: 81%

Proenkephalin-A mRNA Is Widely Expressed in Tissues of the Human Gastrointestinal Tract

Monstein¹,

Grahn²,

Ohlsson

2006

Eur Surg Res

Self Cite

View full text Add to dashboard Cite

Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level.

show abstract

Section: Discussionmentioning

confidence: 81%

Proenkephalin-A mRNA Is Widely Expressed in Tissues of the Human Gastrointestinal Tract

Monstein¹,

Grahn²,

Ohlsson

2006

Eur Surg Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Plasma ghrelin levels are under the control of both cholinergic and adrenergic fibers (Hosoda & Kangawa 2008). Peripherally administered OXT can bind to specific receptors distributed in several organs and throughout the gastrointestinal tract (Gimpl & Fahrenholz 2001, Ohlsson et al 2006. Nevertheless, there are no studies investigating the localization of the OXT receptor in ghrelin-secreting cells of the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men

Vila¹,

Riedl²,

Resl³

et al. 2009

Journal of Endocrinology

View full text Add to dashboard Cite

Oxytocin (OXT) and ghrelin have several common properties such as the involvement in the first phase response to stressors, in appetite regulation, and in the modulation of neural functions. Despite a recent study showing that intraventricular administration of ghrelin activates OXT neurons, little is known on the cross-talk between these two peptides. Here, we investigated the role of the i.v. administration of OXT on circulating ghrelin concentrations under fasting conditions and during the lipopolysaccharide (LPS)-induced endotoxemia. A randomized placebo-controlled cross-over study was performed in ten healthy men. In four study sessions, the participants received once placebo, once OXT (1 pmol/kg per min over 90 min), once LPS (2 ng/kg), and once both OXT and LPS. Plasma ghrelin, glucose, and free fatty acid (FFA) levels were measured at regular intervals during the first 6 h following the LPS bolus. Systemic administration of OXT decreased within 1 h plasma ghrelin levels (611G54 vs 697 G52 pg/ml in placebo days, PZ0 . 013) and increased plasma glucose and FFA concentrations (PZ0 . 002 and PZ0 . 005 respectively). OXT also reduced the LPS-induced surge in ghrelin at time point 2 h (PZ0 . 021). In summary, i.v. administration of OXT decreases circulating levels of ghrelin during fasting, as well as following LPS-induced endotoxemia in healthy men. The cross-talk between OXT and ghrelin might be important in the regulation of energy homeostasis and stress responses.

show abstract

“…Over the past 20 years, preclinical studies have revealed a role for OT in gut function. OT is expressed in the myenteric and submucousal ganglia and nerve fibres along the entire human GI tract (Ohlsson, Truedsson, Djerf, & Sundler, 2006). The role for OT, however, in the physiology and pathophysiology of the bowel has been largely unexplored.…”

Section: Visceral Oxytocin and Emotional Behaviormentioning

confidence: 99%

Calming Cycle Theory and the Co-Regulation of Oxytocin

Welch

Ludwig

2017

Psychodynamic Psychiatry

View full text Add to dashboard Cite

Abstract:The biological functions of oxytocin in attachment and bonding between mother and infant in parturition and breastfeeding and between adults have been studied extensively. However, most current authors have proposed that infant attachment to the mother is learned through operant conditioning mechanisms via the infant's brain and central nervous system. We propose that oxytocin levels in the mother and infant are co-regulated by emotional connection or disconnection, and that the autonomic co-conditioning learning mechanism can be exploited to change a negative physiological and behavioral response between mother and infant into a positive one. Lack of efficacy and scalability of child development therapies that have come out of the attachment theoretical framework have prompted calls for new ideas. Here, we review calming cycle theory, which takes a new view of the emotional relationship of mother and infant, and predicts ways to positively intervene when problems arise. The theory builds upon the research and ideas of Pavlov and his followers and proposes that subcortical Pavlovian co-conditioning of the autonomic nervous systems of mother and infant is the key to maintaining emotional connection between the two and to shaping emotional behavior of the infant into adulthood. We review evidence in support of calming cycle theory from a randomized controlled trial of Family Nurture Intervention (FNI), which is designed to overcome adverse emotional, behavioral, and developmental outcomes in prematurely born infants. Finally, we discuss the role of visceral oxytocin and emotional behavior, and that the conditional motherinfant relationship may affect behavioral changes through anti-inflammatory gut-brain stem vagal signaling.

show abstract

Oxytocin is expressed throughout the human gastrointestinal tract

Abstract: Background/Aim: Several studies have described that oxytocin exerts stimulatory or

Cited by 86 publications

References 26 publications

Proenkephalin-A mRNA Is Widely Expressed in Tissues of the Human Gastrointestinal Tract

Proenkephalin-A mRNA Is Widely Expressed in Tissues of the Human Gastrointestinal Tract

Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men

Calming Cycle Theory and the Co-Regulation of Oxytocin

Contact Info

Product

Resources

About