Oxytocin Modulation of Neural Circuits

Mitre, Mariela; Minder, Jessica; Morina, Egzona; Chao, Moses V.; Froemke, Robert C.

doi:10.1007/7854_2017_7

Cited by 59 publications

(57 citation statements)

References 90 publications

(135 reference statements)

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“…The optogenetically stimulated release of OT balanced the magnitude and timing of inhibitory and excitatory responses in the auditory cortex, resulting in a pattern of activity that resembles responses found in experienced mothers (Marlin, Mitre, D'amour, Chao, & Froemke, 2015). This, and similar experiments in rodents examining olfactory processing (Oettl et al, 2016)have ledtothe hypothesis that OT tunes inhibitory circuits to increase the salience (signal/noise ratio) of important social stimuli (Marlin & Froemke, 2017; Mitre, Minder, Morina, Chao, & Froemke, 2017). …”

Section: Introductionmentioning

confidence: 82%

Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research

Putnam

Young²,

Gothard

2018

American J Primatol

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Oxytocin (OT), a neuropeptide that acts in the brain as a neuromodulator, has been long known to shape maternal physiology and behavior in mammals, however its role in regulating social cognition and behavior in primates has come to the forefront only in the recent decade. Many of the current perspectives on the role of OT in modulating social behavior emerged first from studies in rodents, where invasive techniques with a high degree of precision have permitted the mechanistic dissection of OT-related behaviors, as well as their underlying neural circuits in exquisite detail. In parallel, behavioral and imaging studies in humans have suggested that brain OT may similarly influence human social behavior and neural activity. These studies in rodents and humans have spurred interest in the therapeutic potential of targeting the OT system to remedy deficits in social cognition and behavior that are present across numerous psychiatric disorders. Yet there remains a tremendous gap in our mechanistic understanding of the influence of brain OT on social neural circuitry between rodents and man. In fact, very little is known regarding the neural mechanisms by which exogenous or endogenous OT influences human social cognition, limiting its therapeutic potential. Here we discuss how non-human primates (NHPs) are uniquely positioned to now bridge the gaps in knowledge provided by the precise circuit-level approaches widely used in rodent models and the behavioral, imaging, and clinical studies in humans. This review provides a perspective on what has been achieved, and what can be expected from exploring the role of OT in shaping social behaviors in NHPs in the coming years.

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Section: Introductionmentioning

confidence: 82%

Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research

Putnam

Young²,

Gothard

2018

American J Primatol

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“…Furthermore, from a physiological perspective the central OXT system appears ideally organized to modulate widely distributed neural systems (Bethlehem et al, 2013;Johnson and Young, 2017;Mitre et al, 2017). Relevant properties of the OXT system include not only its central projection profile, somatodendritic release and widely distributed expression of OXT-sensitive receptors in the brain, but also a long half-life after release (20 min) as well as interactions with classical neurotransmitter such as serotonin and dopamine (Bethlehem et al, 2013;Johnson and Young, 2017;Mitre et al, 2017). In line with this conceptual framework, a growing number of recent studies have reported modulatory effects of OXT on the intrinsic functional interplay between widely distributed brain regions across species (e.g.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin modulates the intrinsic dynamics between attention-related large scale networks

Xin

Zhou

et al. 2018

Preprint

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Attention and salience processing have been linked to the intrinsic between-and within-network dynamics of large scale networks engaged in internal (default mode network, DN) and external attention allocation (dorsal attention, DAN, salience network, SN). The central oxytocin (OXT) system appears ideally organized to modulate widely distributed neural systems and to regulate the switch between internal attention and salient stimuli in the environment. The current randomized placebo (PLC) controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis (ICA) approach to determine the modulatory effects of OXT on the within-and between-network dynamics of the DAN-SN-DN triple network system. OXT increased the functional integration between subsystems within SN and DN and increased functional segregation of the DN with the SN and DAN engaged in attentional control. Whereas no sex differences were observed, OXT effects on the DN-SN interaction were modulated by autism traits. Together, the findings suggest that OXT may facilitate efficient attentional allocation towards social cues by modulating the intrinsic functional dynamics between DN components engaged in social processing and large-scale networks involved in external attentional demands (SN, DAN). KeywordsOxytocin / attention / salience / resting-state fMRI / default mode network

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“…These amazing qualities of this neurohormone makes it an interesting candidate for treatment of a number of clinical conditions such as artificial assistance to childbirth, depression, anxiety, autistic spectrum disorder intestinal problems, irritable bowel syndrome etc. [6].…”

Section: Oxytocinmentioning

confidence: 99%

Oxytocin: The Neurohormone

Zafar¹

2016

ACT

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Oxytocin is a peptide hormone, which serves important functions in body including labor management and lactation. Indiction of milk ejection and easy delivery there are many other aspects of in vivo oxytocin functions. Neurotransmission within the body is one of the important vital functions of oxytocin, which validates involvement of oxytocin in emotional, neuronal and behaviour balance of body. Present mini review discusses important facts and phenomenon's associated with oxytocin.

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Oxytocin Modulation of Neural Circuits

Cited by 59 publications

References 90 publications

Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research

Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research

Oxytocin modulates the intrinsic dynamics between attention-related large scale networks

Oxytocin: The Neurohormone

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