Oxytocin stimulates lipolysis, prostaglandin E2 synthesis, and leptin secretion in 3T3-L1 adipocytes

Assinder, Stephen J.; Boumelhem, Badwi B.

doi:10.1016/j.mce.2021.111381

Cited by 8 publications

(6 citation statements)

References 63 publications

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“…First, 3T3‐L1 cells, also known as preadipocytes, were used to differentiate into mature adipocytes by adding adipogenic induction medium as reported previously (Figure 3A,B). The amount of LEP secreted by differentiated adipocytes was much higher than that of the 3T3‐L1 preadipocytes, 20–22 which provided a theoretical basis for the establishment of BC cells and an adipocyte co‐culture model in the next step.…”

Section: Resultsmentioning

confidence: 95%

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Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes

Liu,

Li,

et al. 2023

Cancer Science

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Triple‐negative breast cancer (TNBC) is a special pathological type of breast cancer (BC) with poor prognosis. Obesity is shown to be involved in TNBC tumor progression. The interaction between obesity and BC has generated great attention in recent years, however, the mechanism is still unclear. Here, we showed that leptin secreted by adipocytes upregulated PD‐L1 expression in TNBC through the p‐STAT3 signaling pathway and that baicalein inhibited PD‐L1 expression in tumor microenvironment by suppressing leptin transcription of adipocytes. Collectively, our findings suggest that leptin may be the key factor participating in obesity‐related tumor progression and that baicalein can break through the dilemma to boost the anti‐tumor immune response.

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Section: Resultsmentioning

confidence: 95%

“…The amount of LEP secreted by differentiated adipocytes was much higher than that of the 3T3-L1 preadipocytes, [20][21][22] which provided a theoretical basis for the establishment of BC cells and an adipocyte co-culture model in the next step.…”

Section: Adipocytes Upregulate Pd-l1 Expression In 4t1 Cells By Secre...mentioning

confidence: 94%

Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes

Liu,

Li,

et al. 2023

Cancer Science

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“…Nonetheless, previous studies showed that leptin is directly associated with the inhibition of lipogenesis and promotes lipolysis by acting directly on adipocytes [ 48 ]. This leptin activity might be due to the suppression of the inhibitory action of adenylyl cyclase [ 49 ]. Previous studies suggested that PC regulates adipocyte differentiation [ 8 , 13 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Piceatannol induces regulatory T cells and modulates the inflammatory response and adipogenesis

Rakib¹,

Mandal²,

Showkat³

et al. 2023

Biomedicine & Pharmacotherapy

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“…Other hormones, such as oxytocin and orexins, as well as different interleukins, also stimulate leptin secretion in various cell types. The mechanisms seem to involve an increase in glycemia and insu-linemia in most cases [ 87 , 88 ]. The endocrine stress axis also appears to be implicated in these mechanisms, as epinephrine augments leptin secretion in fish and this could be related to adjust glucose mobilization and energy homeostasis in an adaptive stress response [ 89 ].…”

Section: Regulation Of Leptin Efficiencymentioning

confidence: 99%

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

Casado

Collado-Pérez

Frago

et al. 2023

IJMS

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Excess body weight is frequently associated with low-grade inflammation. Evidence indicates a relationship between obesity and cancer, as well as with other diseases, such as diabetes and non-alcoholic fatty liver disease, in which inflammation and the actions of various adipokines play a role in the pathological mechanisms involved in these disorders. Leptin is mainly produced by adipose tissue in proportion to fat stores, but it is also synthesized in other organs, where leptin receptors are expressed. This hormone performs numerous actions in the brain, mainly related to the control of energy homeostasis. It is also involved in neurogenesis and neuroprotection, and central leptin resistance is related to some neurological disorders, e.g., Parkinson’s and Alzheimer’s diseases. In peripheral tissues, leptin is implicated in the regulation of metabolism, as well as of bone density and muscle mass. All these actions can be affected by changes in leptin levels and the mechanisms associated with resistance to this hormone. This review will present recent advances in the molecular mechanisms of leptin action and their underlying roles in pathological situations, which may be of interest for revealing new approaches for the treatment of diseases where the actions of this adipokine might be compromised.

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Oxytocin stimulates lipolysis, prostaglandin E2 synthesis, and leptin secretion in 3T3-L1 adipocytes

Cited by 8 publications

References 63 publications

Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes

Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes

Piceatannol induces regulatory T cells and modulates the inflammatory response and adipogenesis

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

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