Ozonated water lavage and physiological saline irrigation combined with vacuum-sealed drainage in the treatment of 18 cases of chronic osteomyelitis

Abstract

Objective Ozone is a colorless gas used as a disinfectant and to treat diseases by limiting the effects of bacteria, viruses, fungi, yeast, and protozoa. In this study, we investigated the clinical efficacy of ozonated water lavage and physiological saline irrigation combined with vacuum-sealed drainage (VSD) in the treatment of chronic osteomyelitis. Methods Eighteen patients (14 men and 4 women) with chronic osteomyelitis in the limbs (tibia: 13 cases; femur: 4 cases; humerus: 1 case) admitted to our hospital between April 2012 and October 2018 were selected. The patients were aged 9 to 52 years, with a mean age of 31 years. All patients underwent ozonated water lavage and physiological saline irrigation combined with VSD negative pressure closed drainage during hospitalization. The patients were followed up for 18 to 84 months, with a mean of 31 months. Results Osteomyelitis recurred in only one case of nonunion. The length of hospitalization was 18 to 29 days, with a mean of 21 days. Conclusions A combination of ozonated water lavage, physiological saline irrigation, and VSD provided good clinical effects in the treatment of chronic osteomyelitis, and thus, is recommended for such treatment.

Vacuum sealing drainage combined with naso-intestinal and gastric decompression tubes for the treatment of esophagogastrostomy neck fistula

“…The principle of VSD is to connect negative pressure drainage with normal saline irrigation to ensure adequate drainage of inflammatory substances, creating a closed microenvironment for wound healing [ 16 , 17 ]. Some studies have shown that adding medication irrigation, such as ozonated water and recombinant human epidermal growth factor, could accelerate wound healing [ 18 , 19 ]. Animal experiments have shown that VSD can effectively promote wound healing by increasing the vessel density with hydroxyproline content, reducing the inflammatory responses and generating an ordered collagen arrangement [ 20 ].…”

Application of negative pressure sealing drainage technology combined with silver ion sterilization nursing solution in the nursing of necrotizing fasciitis

“…In hand high-pressure paint injection injury, debridement combined with VSD technology can prevent wound infection and promote the growth of granulation tissue, which is conducive to wound healing. In addition, the study by Yasheng et al 12 showed that negative pressure closed drainage not only had a debridement effect, but also had a good clinical effect in the treatment of chronic osteomyelitis. This is consistent with the results of this study.…”

Comparative analysis of the efficacy of drip drainage surgery and bone cement placement surgery in the treatment of haematogenous osteomyelitis of the extremities

“…The release of antibiotics above the local MIC is more likely to penetrate the bio lm. CS can react with the surrounding tissues to promote bone growth factors such as β-TGF, PDGF, and BMP release at higher than normal levels and thus promote osteogenesis [38].CS also creates a favourable microenvironment for vascularization and corticalization, while PMMA does not promote bone regeneration and needs to be removed a second time [16,36,39]. In a patient who underwent PMMA bone cement placement surgery, using a shaped bone cement wrapped around a Kirschner pin to treat right femoral HO, imaging showed no change in the contour of the bone cement six months postoperatively, and it was present as a foreign body in the bone tissue (Fig.…”

“…Therefore, drip drainage surgery is more recommended for HO patients with long marrow cavities. Long marrow cavities can create conditions for the ow of antibiotic solutions, improve local nutritional status and granulation tissue production, and are more conducive to lowering intramedullary pressure [39,42]. Epiphyseal, focal, or irregular bone lesions are not as effective as in the long marrow cavity due to their morphologic characteristics that prevent adequate irrigation of the infected area with antibiotic solution.…”