Ozonation Of Nucleic Acid Constituents

Légube, B.; Nompex, Ph.; Nadeau, Isabelle; Doré, M.

doi:10.1080/01919512.1992.10555717

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…It is reported that oxidation of proteins by ozone mainly occurs at the tyrosine, tryptophan, histidine, cysteine, and methionine residues, resulting in the abnormal folding ability and changed higher order structures [ 30 ]. As for nucleic acids, the predominant radical reactions happen on the bases of dCMP, dTMP and dGMP, attacking the carbon-nitrogen double bonds [ 31 ], although one study found the predominant reactions seemed to be with the sugar component for dAMP [ 32 ].…”

Section: The Virus Removal By Ozonationmentioning

confidence: 99%

The virus removal in UV irradiation, ozonation and chlorination

Kong

Ren

et al. 2021

Water Cycle

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The COVID-19 pandemic draws much attention to virus inactivation since the SARS-CoV-2 was detected in miscellaneous environments and the wastewater can be a potential transmitting pathway. UV irradiation, ozonation and chlorination are widely used disinfection processes in water treatment. In this review, the mechanisms and applications of three disinfection processes are introduced, and their inactivation effects on virus as well as other microorganisms are compared and discussed. The resistance of viruses to UV irradiation is generally stronger than that of bacteria. 4-log inactivation of bacteria can be easily obtained within a UV dose of 10 mJ/cm 2 . However, the doses to reach the same virus removal rate vary greatly from 10 to 140 mJ/cm 2 . The coronaviruses have even stronger UV resistance. Comparatively, ozonation and chlorination are effective methods to inactivate viruses, and the CT values of 4-log removal for most viruses concerned are lower than 1 mg·min/L and 10 mg·min/L, respectively. Protozoa, fungal spores and bacterial spores are more resistant to disinfection. Temperature, pH, organic matters, turbidity and other parameters all have influences on the disinfection. With a 10 °C decrease in temperature, the CT value required for certain removal rates doubles. Generally low pH promotes disinfection and high pH is against it. In drinking water and wastewater treatment process, the resistance properties of microorganisms and other influence parameters should be taken into consideration when choosing disinfection technologies.

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Section: The Virus Removal By Ozonationmentioning

confidence: 99%

The virus removal in UV irradiation, ozonation and chlorination

Kong

Ren

et al. 2021

Water Cycle

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“…34 In the ozonation of adenine, the oxidation of the C−N bonds was suggested as a reaction mechanism. 36 Although several studies dealt with the ozonation of related nucleobase analogues with regard to kinetics, ozone consumption ratios, and secondary oxidant yield, 30−32,34,36,39−41 no precise conclusions about reaction mechanisms were possible. 2 As adenine and guanine derivatives occur in the wastewater and the environment, it is important to understand their behavior in ozonation.…”

Section: Introductionmentioning

confidence: 99%

“…Studies on the ozonation of the selected structures mostly focused on reaction kinetics, − , − though the reported reaction rates were inconsistent or only available for single experimental conditions and hence not comparable. Nevertheless, an increasing trend from purine to adenine to guanine is noticeable for the reaction with ozone or hydroxyl radicals , at neutral conditions.…”

Section: Introductionmentioning

confidence: 99%

“…A hydrogen shift is followed by opening of the imidazole ring (Figure S1). In the ozonation of adenine, the oxidation of the C–N bonds was suggested as a reaction mechanism . Although several studies dealt with the ozonation of related nucleobase analogues with regard to kinetics, ozone consumption ratios, and secondary oxidant yield, − ,,,− no precise conclusions about reaction mechanisms were possible…”

Section: Introductionmentioning

confidence: 99%

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Insights into the Ozonation of Antiviral Purine Derivatives by the Basic Structures’ Kinetics and Ozone Consumption Ratios

Merkus,

Leupold,

Rockel

et al. 2023

ACS EST Water

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Adenine and guanine derivatives are widely applied as antiviral agents. Due to their incomplete removal in conventional wastewater treatment, these substances were detected in the aquatic environment. Ozonation as an additional treatment step is known to degrade the antiviral compounds. However, oxidation mechanisms are still poorly examined. This study focused on the basic structures of the large group of antiviral nucleobase analogues, purine, adenine, and guanine. Their reaction with ozone allows prognoses of the ozonation of structurally related micropollutants. Therefore, these structures and the two antivirals acyclovir and penciclovir are investigated regarding their kinetics and degradation. Both characteristics are the basis for further research regarding the comprehensive understanding of the purines’ ozonation. Results show differences for the basic structures but similarities between guanine derivatives. Overall, the fundamental examinations exhibit a strong pH-dependency. Investigation of kinetics and ozone consumption ratios at pH 7 indicates ozone attack at nitrogen sites for purine (k < 8 × 10–2 M–1 s–1) and adenine (k = 100 M–1 s–1) with a slight shift to a C-C double bond at a higher pH for adenine. In guanine analogues (k = 3 × 104 M–1 s–1), the attack occurs mostly at carbon. Altogether, knowledge transfer to structurally related micropollutants is possible in the absence of additional strong electron-withdrawing or electron-donating substituents.

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