Ozone disinfection dynamics of enteric viruses provide evidence that infectious titer reduction is triggered by alterations to viral colloidal properties

Bossche, G. Vanden; Wustmann, U.; Krietemeyer, S.

doi:10.1016/s0944-5013(11)80083-2

Cited by 5 publications

(4 citation statements)

References 61 publications

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“…Some authors (7,17) have shown that inactivation of enteric viruses by chlorine is not a linear function of the disinfectant dose. For instance, vanden Bossche et al (40) observed a relationship between the poliovirus 1 inactivation rate and the residual ozone dose which followed a logistic model. This kind of relationship would explain how such a small change in chlorine concentration could lead to an important increase in the ability to inactivate viruses.…”

Section: Discussionmentioning

confidence: 99%

Poliovirus-1 inactivation and interaction with biofilm: a pilot-scale study

Quignon

Sardin

Kiéné

et al. 1997

Appl Environ Microbiol

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A pilot-scale study was initiated to examine the behavior of viruses pulse injected into a distribution system. The influence of a free-chlorine residual and that of virus preadsorption to clay particles was evaluated by tracing the viruses both in the water flow and after elution from the biofilm. These experiments demonstrated, first, that virus preadsorption on 40 mg of Na-montmorillonite per liter increased the residence time of the viruses within the pilot plant by roughly three times and, second, that preadsorption to clay did not prevent viruses from being inactivated by chlorine. Moreover, with no clay added, a greater amount of viruses was recovered from the biofilm than from the water flow (by a factor of 2 or 10 in the absence or presence of chlorine, respectively), indicating a tendency for virus accumulation within biofilms.

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Section: Discussionmentioning

confidence: 99%

Poliovirus-1 inactivation and interaction with biofilm: a pilot-scale study

Quignon

Sardin

Kiéné

et al. 1997

Appl Environ Microbiol

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“…We observed that the inactivation kinetics of the JV-4 reference strain differed strongly from those of the two recently isolated variants tested, which were more resistant. Differences in the inactivation process compared with the test virus have already been described with other enteric viruses and disinfectants (24,25). One parameter involved in this process could be the presence of viral aggregates in suspension.…”

Section: Discussionmentioning

confidence: 88%

“…Viral aggregates would then contribute to the changes of slope in virus survival curves and the loss of GTA efficiency as time is extended. Vanden Bossche et al (24) have shown that with higher ozone levels, particles c Presence (S) or absence (NS) of a statistically significant relationship between survival ratios and exposure time. The numbers in parentheses are the percent confidence levels.…”

Section: Discussionmentioning

confidence: 99%

Comparative sensitivities of Sabin and Mahoney poliovirus type 1 prototype strains and two recent isolates to low concentrations of glutaraldehyde

Chambon

Jallat-Archimbaud

Bailly

et al. 1997

Appl Environ Microbiol

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Significant intratypic differences in the glutaraldehyde (GTA) sensitivity of echovirus isolates have been shown. While exploring ways to optimize the study of GTA sensitivity of enteroviruses, we also observed intratypic differences in poliovirus type 1 isolates collected in France. A suspension procedure was used for assessing the virucidal effect of GTA at low concentrations (<0.10%) against purified viruses. Two recent isolates of poliovirus type 1 tested were first fully characterized by the PCR restriction fragment length polymorphism (RFLP) test. The RFLP pattern of clinical isolate 5617 was similar to that of poliovirus type 1 LS-c, 2ab (Sabin strain), confirming the vaccine origin of strain 5617. The RFLP pattern of strain 5915 recovered from sewage was different from that of the Mahoney strain, suggesting a genetic variation in this wild isolate. We then analyzed under the same controlled conditions the GTA sensitivities of both isolates and their respective prototype strains. The wild Mahoney and 5915 strains exhibited significantly lower sensitivities to GTA than did the vaccine Sabin and 5617 strains. The inactivation rates of clinical isolates 5617 and 5915 were very similar to those of their corresponding reference Sabin and Mahoney strains. Both the conformational structure of the capsid of each strain and the amino acid constitution of structural polypeptides could be involved in the variations observed. The relevance of our comparative sensitivity studies to standardization of virucidal tests is discussed.

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“…Ozone is a powerful oxidant, principally applied as a disinfectant of drinking and waste water (Alvarez and O’Brien 1982; Vanden Bossche et al . 1994; Gundarova et al .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of ozonized sunflower oil (Oleozon)

et al. 2001

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Aims: To evaluate the antimicrobial effect of the ozonized sun¯ower oil (Oleozon) on different bacterial species isolated from different sites. Methods and Results: The effect of Oleozon on Mycobacteria, staphylococci, streptococci, enterococci, Pseudomonas and Escherichia coli was tested. The sun¯ower oil was ozonized at the Centro de Investigaciones del Ozone (CENIC, Havana, Cuba) by an ozone generator. MICs were determined by the agar dilution method. For Mycobacteria, the MIC of Oleozon was determined on solid medium by a microdrop agar proportion test. Oleozon showed antimicrobial activity against all strains analysed, with an MIC ranging from 1á18 to 9á5 mg ml )1 . Conclusions: Oleozon showed a valuable antimicrobial activity against all micro-organisms tested. Results suggest that Mycobacteria are more susceptible to Oleozon than the other bacteria tested. Signi®cance and Impact of the Study: The wide availability of sun¯ower oil makes Oleozon a competitive antimicrobial agent. These results should prompt the setting up of some clinical trials to compare Oleozon with other antimicrobial agents.

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Ozone disinfection dynamics of enteric viruses provide evidence that infectious titer reduction is triggered by alterations to viral colloidal properties

Cited by 5 publications

References 61 publications

Poliovirus-1 inactivation and interaction with biofilm: a pilot-scale study

Poliovirus-1 inactivation and interaction with biofilm: a pilot-scale study

Comparative sensitivities of Sabin and Mahoney poliovirus type 1 prototype strains and two recent isolates to low concentrations of glutaraldehyde

Antibacterial activity of ozonized sunflower oil (Oleozon)

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