Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

Abstract

The search for new topical treatments able to display not only antimicrobial properties but also a multiplicity of other beneficial effects while expressing safe cytocompatibility toward host tissues is being progressively developed. Antiseptics represent an aid to the gold standard nonsurgical treatment Scaling-and-Root-Planing (SRP) for periodontal disease. This split-mouth study aims to assess the efficacy of the ozonized gel GeliO3 (Bioemmei Srl, Vicenza, Italy) plus SRP (experimental treatment), with respect to SRP + chlorhexidine gel. Ten participants were treated with SRP + chlorhexidine gel (control sites) and with SRP + ozone gel (trial sites). After 1 (T1) and 3 months (T2) from baseline (T0), patients were revisited. At each time-point, the following indexes were assessed: probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and bleeding on probing (BoP). It has been assessed that the use of the ozonized gel in addition to SRP did not show significant differences if compared to conventional SRP + chlorhexidine. Chlorhexidine was found to be more effective than ozone in reducing CAL and GI at T2. Ozone deserves consideration for its wide applicability in several clinical fields. In this connection, we also glance at the latest research on ozone therapy.

Effects of an Ozonated Water Irrigator on the Plaque Index and Bleeding Index of Pregnant Women

“…Ozonated water and ozone have a disinfectant power, reduce the signs of inflammation, and inhibit the formation of bacteria that cause halitosis, as demonstrated by the various articles published in the literature on the use of ozone therapy in the dental field [ 10 , 11 , 12 , 13 ]. They were demonstrated to be efficacious in the management of chronic periodontitis [ 14 , 15 ] and oral lichen planus [ 16 ], without the toxic effects of dental pulp cells [ 17 ].…”

Uso da ozonioterapia como tratamento adjuvante não cirúrgico para doenças periodontais: uma revisão integrativa da literatura

“…Em média concentração, pode ser usado como anti-inflamatório na endodontia, para diminuir a ação dos mediadores inflamatórios intrarradiculares. Já em alta concentração, pode ser aplicado em áreas necróticas, devido à sua ação antimicrobiana (Tasdemir et al, 2019;Colombo et al, 2021).…”

“…Assim, as práticas integrativas e complementares em saúde podem exercer um papel fundamental na terapia periodontal. Dentre elas, a ozonioterapia tem crescido seu escopo de atuação na odontologia, sendo utilizada para diversos fins, mediante a concentração estabelecida (Tasdemir, Oskaybas, Alkan & Cakmak, 2019;Colombo et al, 2021).…”

Use and Applicability of Ozone Therapy in Clinical Practice in Dentistry: An Integrative Review

“…A study carried out by Gandhi et al (2019) attested that the adjuvant use of ozonated olive oil in the treatment of chronic periodontitis significantly improves clinical and microbiological outcomes and is as effective as chlorhexidine, while being free of adverse effects. Colombo et al (2021) reported that the use of ozonated gel within a protocol for the nonsurgical treatment of periodontal disease represents a valid approach, even if without a greater effect compared to the group undergoing standard scaling and root planing plus chlorhexidine. This antimycotic efficacy of the ozonized gel is due to the oxidation of microorganisms by the slow release of peroxides (Monzillo et al, 2020).…”