Ozone therapy in periodontics: A meta-analysis

Abstract

Gingival and periodontal diseases constitute a major distress in the field of dentistry. The greater part of the contributing and etiologic factors are diminished or treated with all forms of ozone. Ozone which is well known for its antimicrobial and tissue regenerative properties is indicated in all the stages of gingival and periodontal diseases. The aim of this study was to review literature on the effects of ozone as an adjunct to mechanical therapy in periodontitis patients. A search of literature was conducted to identify articles of ozone therapy in periodontitis published during the period from January 1, 2010, to July 30, 2018. PubMed, Medline, Embase, Cochrane, and Google Scholar search and hand searching of journals were conducted to identify relevant articles. The search strategy employed both dental subject headings and free-text terms. Out of a total of 123 studies that fit the initial inclusion criteria, 117 studies were further excluded. Only six studies were included in the meta-analyses. A high level of heterogeneity in the selected studies was found as demonstrated by Q-value of 10.241 and I 2 value of 80.49%. However, the funnel plots showed symmetrical shape, with prevalence studies indicating absence of publication bias. Ozone therapy can be used effectively as an adjunct to scaling and root planing in the treatment of periodontitis.

Experience with the evidence map in oral ozone therapy - importance for integrative and complementary health practices

“…We identified 26 citations of which 10 systematic reviews (Albedah et al, 2013;Azarpazhooh & Limeback, 2008;Brazzelli et al, 2006;Deepthi & Bilichodmath, 2020;German et al, 2013;Moraschini et al, 2020;Santos et al, 2020;Sharda et al, 2021;Silva et al, 2020;Sridharan & Sivaramakrishnan, 2021) and 16 narrative reviews (Almaz & Sönmez, 2015;Chirumbolo et al, 2021;Domb, 2019;Gupta & Mansi, 2012;Haghighat & Oshaghi, 2020;Lacerda et al, 2021;Lio et al, 2020;Mohammadi et al, 2013;Nogales et al, 2008;Re et al, 2020;Seidler et al, 2008;Suh et al, 2019;Swanson et al, 2021;Tiwari et al, 2017;Trevor Burke, 2012;Tricarico et al, 2020); met the criteria for inclusion in the Map. Most of the reviews were published in the 2008, 2012 and 2014.…”

“…The combined interventions of ozone gas and photodynamic therapy had a positive effect on mandibular osteonecrosis. as well as topical ozonized water in cases of gingivitis, dentin hypersensitivity, halitosis, periodontal diseases, prosthetic stomatitis (Deepthi & Bilichodmath, 2020;Lio et al, 2020;Suh et al, 2019;Tiwari et al, 2017;Tricarico et al, 2020).…”

Efficacy Ozone Therapy in Reducing Periodontal Disease

“…A valid alternative to chlorhexidine could be ozone; it is considered a powerful antimicrobial, especially in its ability to counteract viral reduplication by inhibiting the activity of reverse transcriptase, a part of the viral protein synthesis. The application of ozone in dentistry is the result of its chemical–physical properties such as immunostimulant, analgesic, anti-hypoxic, detoxifying, antimicrobial, bioenergetic, and biosynthetic action [ 29 , 30 , 31 ].…”

Efficacy of ozonated water as a PS in photodynamic therapy: A tool for dental caries management? An in vitro study

“…Topical application of ozone in Dentistry can be managed in different forms: gaseous form, conveyed in the form of oils and in aqueous form, called ozonated water. 1 The use of ozonated water for the treatment of oral pathologies is widely documented in the literature.…”