Ozonetherapy protects from in-stent coronary neointimal proliferation. Role of redoxins

Effects of oxygen ozone therapy on cardiac function in a patient with a prior myocardial infarction

“…One experimental study in animals 18 showed that oxygen/ozone treatment protected the heart from AMIs thanks to a localised The ability of oxygen ozone therapy to lower re-stenosis rates after implanting metal stents in pigs due to its antioxidant and antiinflammatory properties has recently been assessed. 19 The recurrence of the stenosis, re-stenosis, or the lack of re-endothelialisation can occur after percutaneous trans-luminal coronary angioplasty, even when medicated drug-eluting stents are used, due to inflammation and oxidative stress at an endothelial level. Twelve male Landrace pigs (51±9 kg) were subjected to percutaneous transluminal metal stenting in the circumflex coronary arteries under infusion of heparin with fluoroscopic guidance using standard techniques.…”

The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases

“…In addition, Barone et al demonstrated that ozone therapy reduced restenosis 30 days following percutaneous transluminal coronary angioplasty with metal stent implantations in pigs [56]. The authors suggested that ozone autohemotransfusion upregulated the innate detoxifying and antioxidant system (i.e., thioredoxins), preventing post-stenting neointima hyperplasia and an inflammatory reaction, thus supporting successive re-endothelization which may be dependent on the increased glycolysis rate, stimulation of NO synthesis, and induction of growth factors [57,58].…”

Bifunctional investigation of ultra-small SnO2nanoparticle decorated rGO for ozone sensing and supercapacitor applications

“…Ozone is one of the toxic and strong oxidizing gases, with wide usage in various industrial and medical elds. [1][2][3][4][5] It can be produced naturally in the upper level of the atmosphere, called outdoor ozone, and the ground level ozone can be produced by electrical discharge, household materials, etc. This could create acute health effects like pulmonary, cardiovascular and chronic diseases 6 when exceeding the limited threshold value of (0.08 ppm).…”