Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives

Abstract

Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity. Oral Candida is the most common fungal infection in the mouth among denture wearers and people with weakened immune systems. In the case of generalized candidiasis or immunocompromised patients, systemic therapy is needed, while localized infections are treated with topic medications. However, many Candida strains are resistant to antifungal drugs. The aim of this preliminary analysis is to evaluate the antimycotic efficacy of a new ozonided oil (GeliO3), as a possible terapeutic alternative in local treatments of these infections, compared to chlorhexidine digluconate (Plak gel®). Chlorhexidine is a chemical synthesis disinfectant with a broad-spectrum antiseptic action, active against bacteria and fungi. Antimycotic activity was tested against the following four Candida species: C. albicans, C. parapsilosis, C. glabrata, C. tropicalis, through an agar diffusion method. No significant differences were found between the growth inhibition zone diameters of the ozonized gel and chlorhexidine. The results indicated that the ozonized gel may help to combat Candida infections. Moreover, useful applications could be used to counteract Candida colonization of endosseous implants.

Copper-Alloy Surfaces and Cleaning Regimens against the Spread of SARS-CoV-2 in Dentistry and Orthopedics. From Fomites to Anti-Infective Nanocoatings

“…Ozone can be conveyed as a gas or a gel to sanitize the environment. It has been extensively studied and used for many years and its effectiveness has been demonstrated against viruses, bacteria and fungi [ 28 , 31 , 32 , 33 , 34 , 35 ], even if no tests have been conducted on SARS-CoV-2 yet.…”

Efficacy of Toluidine Blue—Mediated Antimicrobial Photodynamic Therapy on Candida spp. A Systematic Review

“…This makes it necessary to look for new therapeutic approaches. Alternative pharmacological antifungal agents have been considered, e.g., essential oils (tea tree oil) [ 14 , 15 ], lemongrass oil [ 16 ], oregano oil [ 17 , 18 ], Cinnamomum cassia [ 19 ], colloidal solutions of metal nanoparticles (silver, gold) [ 20 , 21 ], as well as methods such as ozone therapy [ 22 , 23 , 24 , 25 , 26 , 27 ], photobiomodulation [ 28 , 29 ] and antimicrobial photodynamic therapy (aPDT) [ 30 , 31 , 32 , 33 ]. The most promising of those agents seems to aPDT.…”

Utilização Da Ozonioterapia Em Odontologia/ Use of Ozoniotherapy in Dentistry

“…O ozônio é um composto natural, uma molécula composta por três átomos de oxigênio (1) incolor e com odor pungente, que tem atividade oxidante (2). Sua aplicação em terapias passou a ser vista como alternativa de tratamento em meados de 1930 (3) e, a partir de então, tem sido estudado por diversos pesquisadores.…”