P-049 A population study of correlation between the treatment rate for monoclonal antibodies (Mabs) and mortality rate in patients with metastatic colorectal cancer (mCRC) in Russia

Fedyanin, Mikhail; Polyanskaya, Elizaveta; Sekhina, O.; Tryakin, Alexey; Tjulandin, Sergei

doi:10.1093/annonc/mdw199.47

Cited by 3 publications

(3 citation statements)

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“…На первом этапе было выявлено, что пенетрация ири-нотекана и таргетных препаратов значимо ассоциирована с более низкими показателями смертности в регионе [6]. Это может говорить о том, что назначение второй линии терапии, а иринотекан в РФ чаще применяется во второй линии, и определяет уменьшение смертности.…”

Section: Discussionunclassified

“…К полученным результатам необходимо было относиться с осторожностью, так как на смертность от ме-тастатического рака толстой кишки могут влиять различ-ные факторы. Возможно, что в регионах, где чаще назна-чается адъювантная химиотерапия или чаще выполняется резекция органов по поводу метастазов, чаще назначают вторую линию терапии или назначают моноклональные антитела [6]. В связи с чем было решено провести допол-нительное анкетирование онкологических клиник реги-онов по оценке качества оказания противоопухолевого лечения больным метастатическим раком толстой кишки в 2013 году [7].…”

Section: Introductionunclassified

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Качество Оказания Противоопухолевого Лечения В Популяции Больных Метастатическим Раком Толстой Кишки В Рутинной Клинической Практике

Федянин¹,

Алиева²,

Владимирова³

et al. 2017

Zlokač. opuholi

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Section: Discussionunclassified

Section: Introductionunclassified

Качество Оказания Противоопухолевого Лечения В Популяции Больных Метастатическим Раком Толстой Кишки В Рутинной Клинической Практике

Федянин¹,

Алиева²,

Владимирова³

et al. 2017

Zlokač. opuholi

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“…Specific receptors exist on tumour cells that can be used to identify them. Monoclonal antibodies connect specifically to the receptor surface on tumour cells [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)

Didarian

Vargel

2021

IET Nanobiotechnology

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Intelligent inorganic nanoparticles were designed and produced for use in imaging and annihilating tumour cells by radio-frequency (RF) hyperthermia. Nanoparticles synthesised to provide RF hyperthermia must have magnetite properties. For this purpose, magnetite nanoparticles were first synthesised by the coprecipitation method (10-15 NM). These superparamagnetic nanoparticles were then covered with gold ions without losing their magnetic properties. In this step, gold ions are reduced around the magnetite nanoparticles. Surface modification of the gold-coated magnetic nanoparticles was performed in the next step. A self-assembled monolayer was created using cysteamine (2-aminoethanethiol) molecules, which have two different end groups (SH and NH 2 ). These molecules react with the gold surface by SH groups. The NH 2 groups give a positive charge to the nanoparticles. After that, a monoclonal antibody (Monoclonal Anti-N-CAM Clone NCAM-OB11) was immobilised by the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide method. Then, the antenna RF system (144.00015 MHz) was created for RF hyperthermia. The antibody-nanoparticle binding rate and cytotoxicity tests were followed by in vitro and in vivo experiments. As the main result, antibody-bound gold-coated magnetic nanoparticles were successfully connected to tumour cells. After RF hyperthermia, the tumour size decreased owing to apoptosis and necrosis of tumour cells.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Treatment of tumour tissue with radiofrequency hyperthermia (using antibody-carrying nanoparticles)

Didarian¹,

Vargel²

2020

IET Nanobiotechnology

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P-049 A population study of correlation between the treatment rate for monoclonal antibodies (Mabs) and mortality rate in patients with metastatic colorectal cancer (mCRC) in Russia

Abstract: posters P À 049 A population study of correlation between the treatment rate for monoclonal antibodies (Mabs) and mortality rate in patients with metastatic colorectal cancer (mCRC) in Russia

Cited by 3 publications

References 0 publications

Качество Оказания Противоопухолевого Лечения В Популяции Больных Метастатическим Раком Толстой Кишки В Рутинной Клинической Практике

Качество Оказания Противоопухолевого Лечения В Популяции Больных Метастатическим Раком Толстой Кишки В Рутинной Клинической Практике

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)

Treatment of tumour tissue with radiofrequency hyperthermia (using antibody-carrying nanoparticles)

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