DiabetesDiabetes Mellitus (or diabetes) is the most common metabolic disorder, caused by incapability of body in the metabolism of carbohydrates, fats, and proteins. This failure results in increased level of blood glucose. There are some specific and distinctive types of diabetes. This disorder is caused by complex reactions between genetic and environmental factors. Metabolic regulation disorder, induced by diabetes, results in secondary pathophysiologic changes in several organs, which per se can lead to a significant burden both for the patients as well as the health care system. 1,2 The global prevalence of diabetes significantly increased in the last two decades from about 300million in 1985 to more than 230million in 2004 and 382million in 2013. According to the estimations of the International Diabetes Federation, the number of diabetic patients will reach 592million by 2035. Although the incidence of types 1 and 2 diabetes is globally increasing, this rate is higher for the latter type. This can be due to increased prevalence of obesity, decreased rate of physical activities, and aging, which are all considered as the consequences of industrialization. 1,3 Although, diabetes is a main cause of mortality, some studies suggest that the reported number of deaths among diabetic patients is underestimated. In the United States, diabetes was the seventh cause of mortality in 2010. According to a recent estimate, diabetes is the cause of 5.1million deaths per year (8% of global deaths in 2013). According to the estimates, the diabetics accounted for 11% of global medical expenditures in 2013. 1