P.4.a.005 Role of 5-HT3 receptors in depression-related behaviors and antidepressant treatments

Response of Htr3a knockout mice to antidepressant treatment and chronic stress

“…In our conditions, 5‐HT 1A receptor desensitization occurred in Htr3a KO mice, not WT mice, under the low‐dose citalopram regimen (5 mg·kg −1 ·day −1 ). The amplitude of this desensitization was similar to that observed in WT mice with the 20 mg·kg −1 ·day −1 citalopram regimen (Martin et al, ), commonly used in preclinical studies (Calcagno and Invernizzi, ). Actually, Ferrés‐Coy et al () demonstrated that short‐term partial reduction of 5‐HTT expression by small interference RNA led to decreased in both 5‐HT 1A autoreceptor expression and function.…”