P.c(17)-26 Profil épidémiologique des cancers de la cavité buccale au sénégal

Toure, S.; Sonko, L.; Diallo, B.-K.; Diop, Rudolph; Diop, A.; Diouf, R.; Diop, E.-M.

doi:10.1016/s0035-1768(05)86032-2

Cited by 6 publications

(5 citation statements)

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“…Clinical characteristics of Senegalese patientsdiagnosed with oral cancers have been described by Toure et al in 2005 and highlighted early age at diagnosis (52.6 years), a sex ratio in favor of females (0.67), a negative alcohol-tobacco status (62.9% non-smokers and 83.8% non-alcoholics) and a poor oral hygiene[24]. This profile is quite similar to what observed in our patients.…”

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confidence: 90%

Targeting Mutational Landscape of TP53 in patients diagnosed with Oral Cancer living in Senegal

Diaga

Toure

Elmostafa

et al. 2022

JCGB

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Introduction Genomic mutations in TP53 gene in association with etiological risk factors have been associated with oral carcinogenesis. Herein, we screened for genomic variants of TP53 predisposing to oral cancers in Senegalese patients. Methodology 88 patients with confirmed diagnostic were recruited after informed consent. Blood samples were collected from each patient to perform DNA extraction, PCR amplification of all coding exons of TP53 followed by Sanger Sequencing of PCR products. Nucleotide sequences were analysed with Genalys software. 94 blood donors with no cancer diagnosis were also recruited as controls for association study between the most common variants identified in patients and predisposition to oral cancers. Results Sequence analysis showed that 52.27% of patients carry at least one mutation in TP53. Eleven genomic variants were identified, 7 variants already reported in databases and 4 new variants. The most recurrent variants in this study already reported as cancer-related variants were Pro72Arg (rs1042522; Arginine frequency estimated at 31.26%) and a 16 bp insertion in intron 3 (rs59758982; allelic frequency estimated at 26.25%). Haplotype analysis between these variants showed a strong linkage disequilibrium (D’ = 0.999, r2 = 0.153 and p-value < 0.05). However, association study did not find any significant association with susceptibility to oral cancer (p-value > 0.05). Conclusion Our study highlighted that despite the absence of association between the two most common cancer-related variants in Senegalese patients diagnosed with oral cancer, their strong LD suggested that they could be transmitted together in a common haplotype which may be implicated in oral carcinogenesis.

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confidence: 90%

Targeting Mutational Landscape of TP53 in patients diagnosed with Oral Cancer living in Senegal

Diaga

Toure

Elmostafa

et al. 2022

JCGB

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“…20 However, in West Africa it is reported to be uncommon; we have found virtually no studies on oral cancer outside Nigeria. 10,17,21 In several countries, an increasing trend in the incidence of oral cavity and oropharyngeal cancers has been reported, even in some where tobacco and alcohol control is successfully being carried out, suggesting the influence of new risk factors. 22 In support of these new risk factors, there is also an increasing trend of oral and oropharyngeal cancers in young patients (under 45 years of age) worldwide.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of oral cancers in Benin

Hounkpatin

Bouraima

Flatin

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Background: The objective of the study was to study the epidemiological profile of malignant tumours of the oral cavity in Benin from January 2009 to 31 December 2014.Methods: This was a descriptive cross-sectional study that examined cancers of the oral cavity collected in the registers of the 5 anatomy and pathology laboratories in Benin as well as the only hospital in the country that sends its requests for histological examinations abroad. Results: With a rate of 19.8%, oral cavity cancer was the most frequent cancer localization in the ENT, head and neck sphere in Benin. The most frequent sites of cancers in the oral cavity were the palate (32.2%) followed by the tongue (25.4%) and the inner face of the cheeks (16.9%). The average age of the patients was 53.18±20.60 years with extremes of 1 year and 90 years. The sex ratio was 0.90. Squamous cell carcinoma was the most common histological type with 67.80%.Conclusions: Cancer of the oral cavity must be a priority for health authorities in Benin. Research must be initiated to determine the factors that contribute to it.

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“…Bouyakhef [27] found this factor in 4 patients (11%), the same percentage observed in EL IDRISSI (11%). [29].…”

Section: Discussionmentioning

confidence: 99%

“…Etiologic factors in the occurrence of these lesions are tobacco, alcohol, and Human Papilloma Virus (HPV) infections [30,4]. EL IDRISSI found these lesions in 16.6% of patients [29].…”

Section: Discussionmentioning

confidence: 99%

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Cancers of Oral Cavity Epidemiological and Clinical Study About 70 Cases

Allaye¹,

Faissal²,

Koussay³

et al. 2019

IJCOMS

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Our retrospective study is about 70 cases of cancers of the Oral cavity, collected at the department of maxillo-facial surgery in Mohamed VI hospital university of Marrakech, during 9 years (January 2007-January2016). The mean age has been 60 years (20-94 years old). The women predominate with a ratio, which equal 0.94. Among the etiologic factors, tobacco is 31% of our cases and alcohol 6% of our case _Clinically, the mean delay of consultation has been 8 months_the clinical symptomatology has often consisted in the oral cavity lesions (80%), pain has been the second symptom (33%), the difficulty in swallowing and the difficulty in chewing (18%) and clinical examination showed a ulcero budding tumor in 38% of the cases, the cervical adenopathies have been noticed in 47% of the cases. The definitive diagnosis has been based on the histologic analysis that showed an epidermoid carcinoma in 87% of the cases. According to the TNM classification, the T3 are noticed in 46% and the No is found in 54%. The therapeutic strategy consisted in the surgery alone (58%), the surgery with radiotherapy (33%), the radiotherapy just (9%). Among our patients, we noticed a local recidivism in 3 cases, and we noticedtwo cases of metastasis, 35 patients (50%) are still a live with good carcinologic and functional result, 10 patients died; the other patients have been lost to follow-up.

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P.c(17)-26 Profil épidémiologique des cancers de la cavité buccale au sénégal

Cited by 6 publications

References 0 publications

Targeting Mutational Landscape of TP53 in patients diagnosed with Oral Cancer living in Senegal

Targeting Mutational Landscape of TP53 in patients diagnosed with Oral Cancer living in Senegal

Epidemiological profile of oral cancers in Benin

Cancers of Oral Cavity Epidemiological and Clinical Study About 70 Cases

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