p-Cymene Complexes of Ruthenium(II) as Antitumor Agents

Abstract

In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(η6-p-cymene)RuCl2L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [(η6-p-cymene)RuClL2]PF6; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, respectively. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies.

Synthesis and Characterization of Azo Dye Complexes as Potential Inhibitors of Acetylcholinesterase, Butyrylcholinesterase, and Glutathione S‐Transferase

“…[21,22] Furthermore, a new absorption band was observed at 465 cm À 1 exclusively ruthenium complex can be predicated to Ru-NH 2 stretching frequency or backbonding on p-cymene group. [23]…”

Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy

“…Although the sales volume of metal antitumor drugs such as cisplatin and carboplatin ranks top ten in the global antitumor drug market 5,6 , this type of drugs can cause nausea, vomiting, bone marrow transplantation, liver and kidney toxicity and other side effects [7][8][9][10] . In order to find safe metal antitumor drugs, ruthenium (Ru) complexes have become a big breakthrough in the field [11][12][13][14] .…”

“…[7][8][9][10] In the search for safe metal antitumor drugs, ruthenium (Ru) complexes have become a big breakthrough in the field. [11][12][13][14] In comparison with cisplatin and its derivatives, ruthenium complexes have the following advantages. First, platinum complexes form a four-coordination plane square, whereas ruthenium complexes form six-coordination octahedron mode, and the range of oxidation states is wider than that of platinum (including II, III, IV valence states), which leads to abundant complex structures.…”

Redesigning Nature: Ruthenium Flavonoid Complexes with Antitumour, Antimicrobial and Cardioprotective Activities

“…A large variety of organometallic ruthenium arene complexes with antitumor [ 20 , 21 ] and anti-parasitary [ 22 , 23 ] activities are reported. Within antitumorals, one of most thoroughly studied complexes is [RuCl( p -cymene)(1,3,5-triaza-7-phosphaadamantane)], commonly abbreviated as RAPTA-C [ 24 ].…”