P-selectin and Platelet-Derived Microparticles Associated with Monocyte Activation Markers in Patients with Pulmonary Embolism

Abstract

Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and compared in patients with pulmonary embolism (PE). These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.

Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles

“…35,[46][47] In addition, platelets and PMPs are known to modulate the activity of the cells with which they interact, including monocytes, neutrophils, and endothelial cells. 27,29,35,46,49,50 For example, PMPs are important for platelet-derived CD154 to stimulate the maturation of monocyte-derived dendritic cells. 14 Because circulating PMPs and CD154 increase during inflammation, understanding the role of PMPs in the delivery of CD154 signals and the impact of this delivery on damage has broad implications.…”

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

“…Previous studies have shown platelet reactivity in patients with PE and DVT [7][8][9][10][11][12]. Mean platelet volume (MPV) is a measure of average platelet size [13,14].…”

Coagulation and the Vessel Wall in Pulmonary Embolism

“…39 Elevated EMP levels were found in VTE patients, 40 and platelet-derived microparticle (PMP) levels were increased in PE patients. 41 In another study, it was shown that circulating procoagulant microparticles (CPMPs) and PMPs were significantly elevated in patients with acute PE, compared with those in controls lacking cardiovascular risk factors. However, when CPMP and PMP levels were compared with those of controls who had cardiovascular risk factors, there were no significant differences, emphasizing that the presence of cardiovascular risk factors must be adjusted in conditions with elevated MP levels.…”