P wave duration and dispersion and QT interval in multiple sclerosis

Razazian, Nazanin; Hedayati, Neda; Moradian, Nasrin; Bostani, Arash; Afshari, Daryoush; Asgari, Nasrin

doi:10.1016/j.msard.2014.05.001

Cited by 11 publications

(16 citation statements)

References 22 publications

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“…Multiple sclerosis: In the group of patients, mean P-wave duration, and PWD were significantly longer than normal controls [39].…”

Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 80%

“…Additionally, a statistically significant increase in PDW and Pmax in MD1 patient's subgroup with AF compared to MD1 patients with no arrhythmias [38]. Multiple sclerosis: In the group of patients, mean P-wave duration, and PWD were significantly longer than normal controls [39]. Anorexia nervosa : Increased PWD is observed as a risk for AF in adolescents with anorexia nervosa when compared with the group of controls [40]. Anxiety disorders [5]. Hypochondriac patients: they have significantly higher PWD than those of healthy matched controls.…”

Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 99%

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P-wave dispersion: an update

Pérez‐Riera

Abreu

Barbosa‐Barros

et al. 2016

Indian Pacing and Electrophysiology Journal

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P-wave dispersion (PWD, Pd or Pdis) is a noninvasive electrocardiographic (ECG) marker for atrial remodeling and predictor for atrial fibrillation (AF). PWD is defined as the difference between the widest and the narrowest P-wave duration recorded from the 12 ECG leads. Increased P-wave duration and PWD reflect prolongation of intraatrial and interatrial conduction time with lack of a well-coordinated conduction system within the atrial muscles, with inhomogeneous, asynchronic, pro-inflammatory and anti-inflammatory effect mediated by interleukin-6 (IL-6) in patients with the CG + GG genotype IL-6 -634C/G polymorphism [1] and discontinuous propagation of sinus impulses mainly between the left and right atria, interstitial/extracellular fibroblast activation and collagen deposition with fibrosis (via TGF-β) in atrial tissue, insufficient blood supply, significant not isotropic myoelectric activity, and thin wall thickness and consequent expansion tendency all well-known electrophysiological characteristics in patients with atrial arrhythmias and especially paroxysmal atrial fibrillation (PAF) [2].

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“…Multiple sclerosis: In the group of patients, mean P-wave duration, and PWD were significantly longer than normal controls [39].…”

Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 80%

Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 99%

P-wave dispersion: an update

Pérez‐Riera

Abreu

Barbosa‐Barros

et al. 2016

Indian Pacing and Electrophysiology Journal

View full text Add to dashboard Cite

show abstract

“…25,26 These P wave abnormalities have been found to be associated with an increased risk of atrial arrhythmias. 27,28 P wave abnormalities have been reported to be abnormal in MS patients compared with healthy normal controls.…”

Section: Cardiac Rhythm Dysfunction: Ecg Changes and Arrhythmiasmentioning

confidence: 99%

“…27,28 P wave abnormalities have been reported to be abnormal in MS patients compared with healthy normal controls. 25,26 In general, it may be heightened sympathetic tone that causes a significant increase in P wave dispersion. 29 The abnormalities noted in patients with MS may be the result of increased sympathetic nervous system activity as a result of damage to the normal brainstem reflex pathways.…”

Section: Cardiac Rhythm Dysfunction: Ecg Changes and Arrhythmiasmentioning

confidence: 99%

“…30 Conversely, no significant difference in the QT interval between MS patients and controls was found in another study. 26 Overall, prolongation of the QT interval may reflect an imbalance of ANS pathways such that there is heightened sympathetic tone. 32 In MS, such abnormalities leading to arrhythmias may be a function of brainstem demyelinating plaques disrupting reflex pathways from higher cortical centers.…”

Section: Cardiac Rhythm Dysfunction: Ecg Changes and Arrhythmiasmentioning

confidence: 99%

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