P-wave parameters and cardiac repolarization indices: Does menopausal status matter?

Doğan, Umuttan; Doğan, Nasuh Utku; Basarir, Ahmet Ozgur; Yıldırım, Serkan; Çelık, Çetin; Incesu, F.; Özdemi̇r, Kurtuluş

doi:10.1016/j.jjcc.2012.04.001

Cited by 9 publications

(7 citation statements)

References 52 publications

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“…A study by Siniscalchi et al1) investigated the effects of surgical early menopause on cardiac arrhythmia and demonstrated that surgical menopause and estrogen replacement therapy did not significantly affect atrioventricular transmission and ventricular repolarization time in women. In a study by Dogan et al13) Tp-e interval was significantly reduced while QT intervals and P-wave parameters were not altered in postmenopausal women compared to premenopausal women.…”

Section: Discussionmentioning

confidence: 89%

“…While women are somewhat protected against atherosclerosis during their reproductive years, this can change after the onset of menopause 13). The rate of progression of atherosclerosis increases throughout the menopausal transition, and often asymptomatic cardiovascular changes occur during the postmenopausal stage 3)13). Many pathophysiological processes are affected in atherosclerotic diseases, including changes in the LA, that contribute to the development of AF.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Surgical Early Menopause Patients

Akçay

Çoksevim

Ulubaşoğlu

et al. 2019

J Cardiovasc Imaging

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BACKGROUND This study evaluated the atrial electromechanical delay (AEMD) and the left atrial (LA) mechanical functions in patients with surgical early menopause. METHODS A total of 62 patients were included in the study: 33 patients with surgical early menopause and 29 age- and sex-matched healthy controls. The duration distance from the start of the P wave to the beginning of the A wave for the lateral mitral annulus, septal mitral annulus, and lateral tricuspid annulus was assessed by tissue Doppler echocardiography. The differences in these durations were used to calculate the inter- and intra-atrial mechanical delays. LA volumes were evaluated using the biplane area-length technique, and LA mechanical function values were measured. RESULTS The baseline laboratory and clinical characteristics were similar between the two groups. Surgical early menopause patients displayed increased static atrial electromechanical connection (PA′) times for the septal mitral annulus and lateral tricuspid annulus compared to the controls. However, the lateral mitral annulus, the inter-atrial, the intra-LA, and the right atrial EMD PA′ times were not significantly altered in surgical early menopause patients compared to controls. Importantly, the LA volume index (28.1 ± 8.17 vs. 24.89 ± 7.96 mL/m 2 , p = 0.019), the maximal LA volume (49.6 ± 14.1 vs. 42.9 ± 16.1 mL, p = 0.004), the minimal LA volume (18.4 ± 7.0 vs. 15.2 ± 9.0 mL, p = 0.022), and the atrial precontraction LA volume (31.0 ± 10.9 vs. 24.9 ± 10.1 mL, p = 0.006) were higher in the patients with surgical early menopause compared to the controls. The LA reservoir, conduit and pumping functions and the total, passive, and active emptying volumes were all comparable between the two groups (p = 0.09; 0.06; 0.68; 0.06; 0.48; 0.07, respectively). CONCLUSIONS Patients with surgical early menopause demonstrated impaired atrial electrical delay and electromechanical functions.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Surgical Early Menopause Patients

Akçay

Çoksevim

Ulubaşoğlu

et al. 2019

J Cardiovasc Imaging

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“…In this regard, Nakagawa et al 38 reported that Q-T interval is affected by natural events such as menopause, and probably these variations are in parallel to changes in serum levels of sex hormones, such as estrogen. 39 The exact impact of hormones, especially sex hormones, on arrhythmic mechanisms and cardiac conduction system are unclear. 39 Recently, the results of studies have shown that increased reactive oxygen species (ROS) due to elevated oxidative stress levels increase the cardiac inflammatory indices such as C-reactive protein (CRP) and the increase in age-related apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…39 The exact impact of hormones, especially sex hormones, on arrhythmic mechanisms and cardiac conduction system are unclear. 39 Recently, the results of studies have shown that increased reactive oxygen species (ROS) due to elevated oxidative stress levels increase the cardiac inflammatory indices such as C-reactive protein (CRP) and the increase in age-related apoptosis. 40 Consequently, it is possible that atrial negative regulation leads to a pre-excitation syndrome or a block in the AV node in post-menopause period.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

Tartibian

Afsargharehbagh

Malandish

et al. 2018

Int J Basic Sci Med

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Introduction: electrocardiogram (ECG) indices as a valuable tool for the diagnosis depolarization and repolarization of the myocardium are affected by aerobic exercise and detraining. The purpose of this study was to investigate the effects of 12-week moderate-intensity aerobic exercise and 5 months detraining on electrocardiogram (ECG) indices in post-menopausal women. Methods: Twenty-four post-menopausal women aged 50-70 years were randomly assigned to Exercise (E, n=12) and Control (C, n=12) groups. E group performed of 12 weeks moderate-intensity aerobic exercise program (W-WJMIAEP-R), and then 5 months detraining remained, but the C group participated in no intervention during 8-month. The ECG indices were measured at baseline, after 12-week exercise, and after 5-month detraining. Results: After 12-week in between-groups, ECG indices were not significantly different (P>0.05), except P-R interval (P≤0.05). After 5-month detraining in between-groups were not a significant difference for dependent variables (P>0.05), except P-R segment and S-T interval (P≤0.05). Conclusion: The Results suggest that 12 weeks of W-WJMIAEP-R increases P-R interval in sedentary post-menopausal women that is likely to be effective in preventing heart arrhythmias. The P-R segment and S-T interval decreased significantly after 5 months detraining period that 12 weeks W-WJMIAEP-R induced-ECG positive adaptations such as decrease P-R segment and S-T interval are maintained even after 5-month detraining and consequently prevents the increase in atrial aging process in postmenopausal women.

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“…The cardiovascular system also suffers from structural or functional impairment [1–3]. Several studies showed that estrogen deficiency increased cardiovascular risk factors and subsequently increased cardiovascular morbidity and mortality [4, 5], and myocardial injury can take place in asymptomatic women in postmenopause [6, 7].…”

Section: Introductionmentioning

confidence: 99%

The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model

Zhang

Xiang

Zhao

et al. 2018

BMC Complement Altern Med

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BackgroundEr-Xian decoction (EXD), a formula of Chinese medicine, is often used to treat menopausal syndrome in China. The aim of the present study was to explore the potential cardioprotective mechanism of EXD against myocardial injury in an ovariectomy-induced menopausal rat model.MethodsWe divided the female Wistar rats into ovariectomy group and sham operation group (SHAM group). The ovariectomized (OVX) rats received treatment of vehicle (OVX group), EXD (EXD group) or 17β-estradiol (E2 group). After 12-week of treatment, the level of estradiol in serum was detected using an electrochemiluminescence immunoassay, and electrophysiologic changes in myocardial action potentials (AP) were evaluated using intracellular microelectrode technique. Changes in the histopathology of the left ventricle and the ultrastructure of the cardiomyocytes were observed by hematoxylin and eosin (HE) staining and transmission electronmicroscopy to assess myocardial injury. Microarrays were applied for the evaluation of gene expression profiles in ventricular muscle of the OVX and EXD rats. Further pathway analyses of the differential expression genes were carried out using the Kyoto Encyclopedia of Genes and Genomes (KEGG). And real-time quantitative RT-PCR (qRT-PCR) was used for verification of the key findings.ResultsThe results from electrophysiological and histomorphological observations demonstrated that EXD had a substantial myocardial protective effect. The EXD-treated rats, in comparison with the OVX rats, demonstrated up-regulated expression of 28 genes yet down-regulated expression of 157 genes in the ventricular muscle. The qRT-PCR assay validated all selected differential expression genes. The KEGG pathway analysis showed that the down-regulated genes were relevant to cardiomyopathy and myocardial contractility. EXD could decrease the mRNA expressions of cardiac myosin (Myh7, Myl2) and integrin (Itgb5) in the ventricular myocardium.ConclusionEXD had a protective effect against myocardial injury in OVX rats, and this cardioprotective effect may be associated with modulation of the expression of cardiac myosin or integrin at the mRNA level.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2311-9) contains supplementary material, which is available to authorized users.

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P-wave parameters and cardiac repolarization indices: Does menopausal status matter?

Cited by 9 publications

References 52 publications

Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Surgical Early Menopause Patients

Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Surgical Early Menopause Patients

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model

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