“…Stilbene disulfonates specifically interact with AE proteins at sites that competitively block anion flux [22-241. This study shows that these compounds stimulate B cell proliferation by interacting with surface receptors that are pharmacologically related to AE proteins on lymphocytes. For example, niflumic acid is a noncompetitive antagonist which specifically blocks binding of the stilbene disulfonate analog 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) to AE proteins [25,26] Stilbene disulfonic derivatives used as AE inhibitors were DIDS (Aldrich Chemical Co. Inc., Milwaukee, WI), 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (SITS; Sigma Chemical Co., St. Louis, MO), 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS; Aldrich), and 4,4'diazidostilbene-2,2'-disulfonic acid (DAzDA; Fluka Chemical Corp., Ronkonkoma, NY). Niflumic acid (Sigma) was used as a specific inhibitor of DIDS.…”