P02.09: Isolated placental aneuploidy associated with spontaneous resolution of hydrops fetalis

Abstract

accuracy of prenatal diagnosis at our center is 73.2% (205/280). The four most accurate systems are abdominal wall (accuracy: 100%), hydrops fetalis (100%), thorax (100%), and gastrointestinal (82.2%) system. The four most inaccurate systems are heart (49%), musculoskeletal (66.7%), face and neck (70.8%), and neural axis (73.5%) system. The differences of accuracy in each system are statistically significant (p < 0.01). Conclusions: Our results show that the accuracy of ultrasound for detecting fetal anomaly differs according to fetal anatomical system. To improve the accuracy system oriented training program for fetal ultrasound is needed. P02.09Isolated placental aneuploidy associated with spontaneous resolution of hydrops fetalis We describe a case of transient mid-gestational hydrops fetalis identified by ultrasound in a 32-year-old woman, gravida 1, para 0, at our prenatal diagnosis unit. The first-trimester ultrasound showed increased nuchal translucency (3.0 mm), which was above 95th percentile for the crow-rump length (41 mm). Fetal nasal bone was present and the Doppler velocity waveform in the ductus venosus was normal. Karyotyping was offered owning to the increased nuchal translucency. Cytogenetic analysis revealed an abnormal placenta double trisomy in twenty cells analyzed (48 XX,+ 15,+ 20), but the fetus was alive and well at the 16th week of gestation. Therefore, an amniocentesis was performed and showed a normal 46,XX karyotype. Ultrasound revealed the resolution of the nuchal translucency. A detailed ultrasonographic examination performed at 19 weeks of gestation detected severe hydrops fetalis. Specialist fetal echocardiography showed a structural normally connection heart with no obvious structural defect. Two weeks later, a new scan showed only mild hydrops, and two weeks later the ultrasound was normal. The fetus was delivered at 38 week's gestation by Cesarean section. Her weight was 3025 g with Apgar scores of 9 and 10 at 1 and 5 min, respectively. The placenta histopathologic examination was normal. The newborn was evaluated with detail and no abnormality was demonstrated. At now (after 5 months) the infant's evolution is normal for its age. Results: The incidence of SUA in our population resulted 0.18%. Of these, 30cases were normal pregnancies at birth and 11 cases presented antenatal complications included growth retardation (n = 3) at delivery and eight congenital malformations such as acrania (n = 1), congenital diaphragmatic hernia and hypoplastic Lt heart syndrome (n = 1), Tetralogy of Fallot (n = 1), Tracheoesophageal atresia (TEA) with imperforated anus (n = 1), Omphalocele with choroids plexus cyst (CPC) (n = 1), and renal anomalies (unilateral renal agenesis n = 2, pelviectasis n = 1). Karyotype determinations by amniocentesis were in two cases and all were revealed normal. Abortus karyotype of omphalocele with CPC was Trisomy 18. Termination of pregnancy was done in four cases with major anomaly except renal anomaly and TEA with imperforated anus case. One TEA with imperforat...