P061 Methylation status of the p15INK4b and p16INK4a genes in pediatric primary myelodysplastic syndrome

Frequency of deletion of CDKN2A (9p21) gene in T-cell lymphomas in FISH analysis

“…The CDKN2A gene encodes two proteins, p14 and p16, and the CDKN2B gene p15 protein. The CDKN2A-2B region is often deleted in human solid tumours and haematological malignancies, and there is also described hypermethylation of the promoter region, which causes inactivation of the gene [11][12][13][14][15][16][17][18][19][20]. Loss of this region is rarely seen in the karyotype; most patients have submicroscopic deletions.…”