P099 a Pharmaco-Epidemiological Approach to Estimate Ibd Prevalence and Incidence in Portugal

Magro, Fernando; Portela, F.; Lago, Pedro Más; Deus, José Ribeiro de; Vieira, A.C.; Peixe, Paula; Cotter, Jorge; Cremers, Isabelle; Cravo, Marília; Tavares, Luciane Santiago; Junior, José dos Reis; Gonçalves, Rubén Miranda; Caldeira, Patrícia Carlos; Lopes, Hélder; Ministro, Paula

doi:10.1016/s1873-9954(08)70110-1

Cited by 5 publications

(7 citation statements)

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“…Based on mesalamine consumption in the year 2005 and considering a daily drug intake‐defined dose (DDD) of 2 g/day, the prevalence of IBD in Portugal was estimated to be 118 per 100,000 inhabitants, that is, 12,508 estimated Portuguese patients with IBD. The same study estimated a prevalence of CD of 60 per 100,000 inhabitants 5. Based on these numbers, we believe that half of the CD patients in Portugal were included in this study, which may be considered a representative sample.…”

Section: Discussionmentioning

confidence: 85%

Crohnʼs disease in a southern European country: Montreal classification and clinical activity

Magro¹,

Portela²,

Lago³

et al. 2009

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 85%

Crohnʼs disease in a southern European country: Montreal classification and clinical activity

Magro¹,

Portela²,

Lago³

et al. 2009

Inflammatory Bowel Diseases

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“…This figure is based on mesalamine consumption during the year 2005 and a daily drug intake-defined dose of 2 g/day. The same study estimated a prevalence of CD of 60 per 100,000 inhabitants, giving an estimated 6,400 Portuguese patients with CD [7]. It is possible to use mesalamine consumption as a measure of CD prevalence in Portugal as most patients with CD are prescribed this drug.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Bowel Disease: A Patient’s and Caregiver’s Perspective

Magro¹,

Portela²,

Lago³

et al. 2009

Dig Dis Sci

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The purpose of this study was to conduct a survey examining the impact of inflammatory bowel disease (IBD) on patients' and their caregivers' daily activities. Questionnaires were distributed to patients registered in the APDI (Portuguese Association for IBD) database and their respective caregivers in 2007. Of 422 patient respondents, 251 had Crohn's disease (CD) and 171 had ulcerative colitis (UC), with the majority of patients being women (58.1%) and aged over 40 years (37.4%). The number of disease flares experienced by IBD patients was slightly higher for patients with CD than for patients with UC (2.64 vs. 2.34), and surgery was more often required in CD patients as compared to UC patients (42.4 vs. 7%). Sixty percent (60%) of patients reported having no problems with mobility, daily activities, or personal hygiene; however, over half of all patients experienced some pain and anxiety. Adult patients and children and adolescents respectively experienced time off work or school due to their disease but caregivers were not affected in this regard. The caregivers life (N=324) was affected by anxiety, with the major concern reported as the risk of the patient developing cancer. Both IBD patients and caregivers thought that the provision of information on new drugs and contact time with a doctor would have the biggest impact on improving care. The symptoms and complications of IBD have a considerable impact on the lives of patients and their caregivers, and several actions could be taken to improve their care.

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“…In our study, we identified 104 patients with UC diagnosed between January 1, 2000 and December 31, 2004, in a population of 509,000, which is contained in the incidence reported in the literature [10,11].…”

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis: Are We Neglecting Its Progressive Character

Massinha

Portela

Campos

et al. 2017

GE Port J Gastroenterol

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"lead pipe," 16% with pseudopolyps, and 3% with stenosis and fibrous bridges. Reference to functional anorectal disorders was identified in 49%, mostly previous and self-limited episodes of incontinence, but including persistent incontinence in 10% (CCIS 8 ± 4.8). There was an increased incidence of structural damage and anorectal dysfunction in patients who needed corticosteroid therapy (p = 0.001), immunosuppressants (p < 0.001), and anti-TNFs (p = 0.002) and an association of structural damage with anorectal dysfunction (p < 0.001). There was no association between age and anorectal dysfunction, including incontinence episodes. Conclusions: UC is a disease with structural and functional consequences in a significant subset of patients. This should be incorporated when defining the therapeutic strategy. AbstractIntroduction: Ulcerative colitis (UC) is a chronic disease but its progressive character, with structural damage, is insufficiently studied. Objectives: To analyze a group of patients without referral bias, regarding its clinical course, the morphological damage, and functional status. Methods: We evaluated UC patients diagnosed between January 1, 2000 and December 31, 2004, living in the direct referral area of the hospital and determined the medication use, colectomy rate, structural damage ("lead pipe," stenosis, pseudopolyps, fibrous bridges), and anorectal function (prospective evaluation with the Cleveland Clinic Incontinence Score [CCIS] and the Fecal Incontinence Quality of Life Scale). Results: We identified 104 patients, 47% female, with a mean age at diagnosis of 38 ± 17 years, 24% with proctitis, 57% with left colitis, and 19% with pancolitis. In 3 patients, it was not possible to obtain follow-up data. Of the studied patients, 56% needed corticosteroid therapy, 38% immunosuppressants, and 16% anti-tumor necrosis factors (anti-TNFs). After a mean follow-up of 13 ± 2 years, we found structural damage in 25 patients (24%): 5% with proctocolectomy, 15% with ResumoIntrodução: A colite ulcerosa (CU) é uma doença crónica mas o seu carácter progressivo, com danos estruturais, encontra-se insuficientemente estudado. Objetivos: Analisar um grupo de doentes, sem viés de referenciação, quanto ao percurso clínico, aos danos morfológicos e ao estado funcional. Métodos: Avaliaram-se os doentes com diagnóstico de CU estabelecido entre 01-01-2000 e 31-12-2004, com residência na área de referenciação directa do hospital, tendo-se determinado a medicação usada, a taxa de colectomia, os danos estruturais ("cano de chumbo", estenoses, pseudopolipos, pontes fibrosas) ou funcionais ano-rectais (avaliação prospectiva com Cleaveland Clinic Incontinence Score, CCIS e Fecal Incontinence Quality of Life, FIQL). Resultados: Identificaram-se 104 doentes, 47% do sexo feminino, idade média no diagnós-tico de 38 ± 17 anos, proctite 24%, colite esquerda 57%, pancolite 19%. Em 3 doentes não foi possível obter dados de seguimento. Dos doentes estudados 56% tiveram necessidade de corticoterapia, 38% de imunossupressores e ...

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P099 a Pharmaco-Epidemiological Approach to Estimate Ibd Prevalence and Incidence in Portugal

Cited by 5 publications

References 0 publications

Crohnʼs disease in a southern European country: Montreal classification and clinical activity

Crohnʼs disease in a southern European country: Montreal classification and clinical activity

Inflammatory Bowel Disease: A Patient’s and Caregiver’s Perspective

Ulcerative Colitis: Are We Neglecting Its Progressive Character

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