P1.13-07 Comparison of the 7th and 8th Edition of TNM Staging for NSCLC in Patients Undergoing Pulmonary Resection After Neoadjuvant/Induction Treatment

Melek, Hüseyin; Sevinç, Tolga Evrim; Çetinkaya, G.; Bayram, Ahmet Sami; Deligonul, Adem; Çubukçu, Erdem; Evrensel, Türkkan; Sarıhan, Süreyya; Gebitekin, Cengiz

doi:10.1016/j.jtho.2019.08.1144

Cited by 1 publication

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“…The former studies report that the five-year overall survival rate is 21 to 41% [1,2,4,5]. In this study, we found median survival to be 48.1 months and five-year overall survival rate to be 45.6% in 250 pneumonectomy cases.…”

Section: Discussionsupporting

confidence: 56%

“…Nonetheless, the role of neoadjuvant therapy is still questionable. Some series report lower postoperative mortality following neoadjuvant therapy [2], while others report higher early postoperative mortality [14] or higher mortality only in right pneumonectomy [15]. Our study showed a statistically significant difference in early mortality following neoadjuvant therapy.…”

Section: Discussionsupporting

confidence: 42%

“…Similarly, we also observed higher early mortality rates in right pneumonectomies (9.3% vs. 5.1%, p = 0.26). The common reason for high mortality in right pneumonectomy include more bronchopleural fistula rate at the right side, the postoperative cough not being adequately effective due to the lengthiness and position of the left main bronchus, and the functional predominance of the ablated lung [2,11]. Among our study population, 10 of 14 patients undergoing early rethoracotomy following pneumonectomy had right pneumonectomy.…”

Section: Discussionmentioning

confidence: 98%

“…Nevertheless, this procedure is still performed due to anatomic or technical reasons. Pneumonectomy accounts for 10 to 35% of all lung resections [2,3]. The tumors for which pneumonectomy is needed are often larger and centrally 106 © Current Thoracic Surgery.…”

Section: Discussionmentioning

confidence: 99%

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Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Yazgan¹,

Gürsoy²,

Üçvet³

et al. 2018

Curr Thorac Surg

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Background: This study aims to evaluate the mortality and survival rates of patients undergoing pneumonectomy due to primary non-small cell lung cancer (NSCLC) and to identify the factors which affect these variables. Materials and Methods: This retrospective single center cohort study included a total of 250 patients who underwent pneumonectomy due to NSCLC between January 2007 and July 2015. 30-and 90-day mortality rates and survival rates of the patients were analyzed. The factors which affected survival and mortality were evaluated. Results: The mean age was 59 (range: 35 to 77) years. The median survival was 48.1 months (95% C. I. 30.6-65.6 months) and five-year survival rate was 45.6%. The 30-and 90-day mortality rates were 6.4% and 7.6%, respectively. Age, nodal disease, and complete resection were factors to affect the survival (p = 0.002, p = 0.0001 and p = 0.017, respectively). Age was also effective on 30-and 90-day mortality (p = 0.004, RR: 3.3 and p = 0.006, RR: 2.5, respectively). The early rethoracotomy rate was 5.6% (n = 14) and the postoperative mortality rate in these patients was 28.6% (n = 4). Conclusions: Although implementation of pneumonectomy due to lung cancer seems fearful, the present study found lower survival rates only depending on advanced age and N2 disease. The high levels of 30-and 90-day mortality and the increased mortality after early rethoracotomy was associated with advanced age and comorbidity. In terms of postoperative mortality, the selection of eligible patients is important in elderly patients who are candidates of pneumonectomy due to lung cancer.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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