P1‐378: Neurostructural predictors of Alzheimer's disease: A meta‐analysis of VBM studies

Ferreira, Luiz Kobuti; Diniz, Breno S.; Forlenza, Orestes Vicente; Busatto, Geraldo F.; Zanetti, Marcus V.

doi:10.1016/j.jalz.2010.05.932

Cited by 18 publications

(21 citation statements)

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“…As expected, atrophy in the AD group was confined to temporal and posterior regions [66], including the amygdala, the temporal pole, the HP, the precuneus, the inferior temporal gyrus and the fusiform gyrus. Lesion overlap in the FIS sample showed fronto-insular lobe damage, with the IC and the ACC being most severely compromised (figure 1; electronic supplementary material, §2.4.1, tables S4 and S5 for detailed areas of atrophy).…”

Section: (D) Imaging Results (I) Atrophy Patterns and Lesion Overlapsupporting

confidence: 81%

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

García‐Cordero

Sedeño

Fuente

et al. 2016

Phil. Trans. R. Soc. B

158

259

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Section: (D) Imaging Results (I) Atrophy Patterns and Lesion Overlapsupporting

confidence: 81%

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

García‐Cordero

Sedeño

Fuente

et al. 2016

Phil. Trans. R. Soc. B

158

259

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“…58 Potential clinical applications The observed neuroplastic effects of the presented video gaming intervention could be well suited as an intervention counteracting known risk factors for mental disease. Post-traumatic stress disorder 59,60 as well as neurodegenerative diseases such as dementia of the Alzheimer type 61,62 have consistently been associated with reduced hippocampal volume. Similarly, prominent biological markers of schizophrenia are volume reductions in hippocampus and prefrontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Playing Super Mario induces structural brain plasticity: gray matter changes resulting from training with a commercial video game

et al. 2013

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Video gaming is a highly pervasive activity, providing a multitude of complex cognitive and motor demands. Gaming can be seen as an intense training of several skills. Associated cerebral structural plasticity induced has not been investigated so far. Comparing a control with a video gaming training group that was trained for 2 months for at least 30 min per day with a platformer game, we found significant gray matter (GM) increase in right hippocampal formation (HC), right dorsolateral prefrontal cortex (DLPFC) and bilateral cerebellum in the training group. The HC increase correlated with changes from egocentric to allocentric navigation strategy. GM increases in HC and DLPFC correlated with participants' desire for video gaming, evidence suggesting a predictive role of desire in volume change. Video game training augments GM in brain areas crucial for spatial navigation, strategic planning, working memory and motor performance going along with evidence for behavioral changes of navigation strategy. The presented video game training could therefore be used to counteract known risk factors for mental disease such as smaller hippocampus and prefrontal cortex volume in, for example, post-traumatic stress disorder, schizophrenia and neurodegenerative disease.

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“…This section followed to a large extent, methods applied in a previous ALE meta-analysis (Ferreira et al, 2009). In order to collect studies for this section, in 07/20/2010 and 07/21/2010 we systematically searched Medline, ISI Web of Science and Scopus, using the keywords: [("fMRI" or "Voxel" or "neural correlates" or "brain correlates" or "brain imaging") and ("ToM" or "Theory of Mind" or "Social Cognition")], and retrieved all (and only) full experimental papers, written in English, whose abstracts suggested to hold data that meet our purpose.…”

Section: Methodsmentioning

confidence: 99%

“…Finally, clusters that passed the threshold were overlaid onto an anatomical MNI template, using MRIcron software (http://www.sph.sc.edu/comd/rorden/mricron/), as described elsewhere [13] . To normalize spatial coordinates into a single stereotactic space, we transformed MNI into Talairach coordinates, following standard instructions, as described by [14] (for details: http://imaging.mrc-cbu.cam.ac.uk/imaging/ MniTalairach).…”

Section: Methodsmentioning

confidence: 99%

Overcoming methodological limitations in theory-of- mind neuroscientific experiments: A voxel based meta-analysis of verbal and non-verbal theory of mind studies

Ando¹,

Dias

McNamara³

2013

JBGC

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Components of neuropsychological tests commonly employed by neuroimagers in developing a metric for Theory of Mind (ToM) research are currently extremely mixed. Tests commonly include factors which may be separate from the core ToM component such as emotion, morality and verbal skills. We explore these confounds, and hypothesize that the discrepant conclusions that have arisen in neuroimaging ToM research reflect the degree to which a task is confounded by these factors. To test this hypothesis we conduct a coordinate based activation likelihood estimations (ALE) meta-analysis of neuroimaging studies. The results demonstrate divergences in neuroimaging results are predicted by divergences in the use of verbal or non-verbal tasks. In response to this finding we systematically describe the main dimensions that should be excluded and included in an ideal ToM task drawing on the wide literature surveyed. We argue, good tasks should rely on minimum verbal content; avoid excessive empathic and moral reactions; include human-like figures executing purposeful behaviors; present several standardized phases, with increased levels of difficulty; and incorporate a clear scoring system, so that performance can be categorized. In order to try to accomplish these goals, we introduce the new 'Inverted Comic Strips Task'.

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P1‐378: Neurostructural predictors of Alzheimer's disease: A meta‐analysis of VBM studies

Cited by 18 publications

References 0 publications

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

Playing Super Mario induces structural brain plasticity: gray matter changes resulting from training with a commercial video game

Overcoming methodological limitations in theory-of- mind neuroscientific experiments: A voxel based meta-analysis of verbal and non-verbal theory of mind studies

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