P1.91. Assessment of systemic effects of ginger on salivation in patients with post-radiotherapy xerostomia

Chamani, Goli; Zarei, Mohammadreza; Mehrabani, Mehrnaz; Kalaghchi, Bita; Aghili, Mahdi; Alaee, Arezoo

doi:10.1016/j.oos.2009.06.377

Cited by 5 publications

(7 citation statements)

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“…Systemic agents were evaluated by 3 studies. Ginger capsules swallowed three times a day over a period of 14 days, did not significantly improved xerostomia nor OHRQoL in patients with post-radiotherapy xerostomia, when compared to a control group ( 27 ). A herbal infusion containing Malva sylvestris and Alcea digitata was reported to be effective improving dry mouth sensation ( 28 , 29 ) and OHRQol ( 29 ) by two randomized-controlled trials ( Table 2 , Table 2 cont.).…”

Section: Resultsmentioning

confidence: 73%

“…Ginger is commonly used in traditional Indian and Chinese medicine, and has been suggested to be effective for oral candidiasis and dry mouth ( 22 ). As a treatment agent for dry mouth, we found it in two different presentations; capsules ( 27 ) and spray ( 22 ), but only the presentation as a spray reported to be significant in decreasing dry mouth symptoms and in increasing salivary output ( 22 ). Apparently, ginger effects for improving dry mouth symptoms are associated with a local stimulant activity rather than a systemic way of action.…”

Section: Discussionmentioning

confidence: 99%

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Treatment alternatives for dry mouth: A scoping review

Niklander¹,

Martínez²,

Miranda³

et al. 2022

J Clin Exp Dent

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Background Saliva is a biological fluid essential for the maintenance of a proper oral health. Its absence predisposes to differences pathologies, including dental caries, fungal infections among many others, significantly affecting the oral health related quality of life (OHRQoL). There is a large variety of treatment alternatives available for dry mouth, which increases constantly. Objective: To identify new treatment alternatives for dry mouth. Material and Methods We conducted a systematic search in PubMed/MEDLINE, Web of Science, Scopus and Ebsco. Articles published between January 2015 and January 2020 were retrieved and reviewed by two independent evaluators. Results Nineteen studies met the inclusion criteria and were included for analysis. Local therapies were the most evaluated agents, followed by systemic and non-conventional treatments. Most local therapies showed certain utility for the management of dry mouth and the improvement of OHRQoL. These formulations were mainly based on natural agents, including malic acid, thyme honey, ginger, among others. Conclusions Local agents are first line treatment alternatives for dry mouth sensation, with a reported efficiency that varies between studies, and with a low number of reported adverse side-effects. Nevertheless, care must be taken when interpreting these results, as is difficult to compare studies within each other due large heterogeneity in study design and outcomes being measured. Key words: Xerostomia, dry mouth, hyposalivation, saliva, mouth dryness.

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Section: Resultsmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Treatment alternatives for dry mouth: A scoping review

Niklander¹,

Martínez²,

Miranda³

et al. 2022

J Clin Exp Dent

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“…Xerostomia is defined as a subjective sensation of oral dryness, [1][2][3] and its prevalence may be as high as 13% in the general population.…”

Section: Introductionmentioning

confidence: 99%

“…Xerostomia is defined as a subjective sensation of oral dryness, 1‐3 and its prevalence may be as high as 13% in the general population. The prevalence of xerostomia ranges from 9.3% in patients aged 15 to 34 years, to 26.5% in those over 75 years of age.…”

Section: Introductionmentioning

confidence: 99%

Translation and validation of a French version of the Xerostomia Inventory

Pierrard

Grenier²,

Dramé

et al. 2022

Gerodontology

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Objective This study aimed to assess the transcultural adaptation and psychometric properties of the French‐language version of the Xerostomia Inventory (XI‐Fr). Methods In total, 65 patients aged 65 years or older were recruited from three departments of a single French hospital. Patients had to have a Mini Mental State Examination score of 10 or more and be able to read and write French. The XI‐Fr was administered to all patients after transcultural adaptation, at the start of the study, and again at 7 days after inclusion. We assessed reliability, acceptability, validity, internal consistency and reproducibility of the instrument in its French‐language version. Results The XI‐Fr showed good internal consistency (Cronbach's alpha 0.79) and good reliability (intra‐class correlation 0.83) at 7 days. Convergent validity showed no relation between salivary flow and XI‐Fr score, as with the original instrument. Discriminant validity showed a positive correlation between the XI‐Fr and the GOHAI, but no difference for the MNA or miniGDS scores. Conclusion The XI‐Fr is a valid and reliable measure of xerostomia in French, with psychometric properties comparable to those of the original English‐language version.

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“…Most xerostomia treatments focus on keeping the mouth moist [ 6 ]. Symptomatic therapies are also used to increase salivation, such as sugar-free gum, herbal remedies like ginger, water gargling, and systemic parasympathomimetic agents, including pilocarpine, bethanechol, and cevimeline [ 11 – 13 ]. Pilocarpine is a cholinergic parasympathomimetic agonist that interacts with the muscarinic-M3 receptors and can produce smooth muscle contraction and stimulates salivary glands’ function.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the 1 and 2% pilocarpine mouthwash in a xerostomic population: a randomized clinical trial

et al. 2022

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Aims & background Pilocarpine is an accepted treatment for xerostomia, but limited research has been conducted on the oral, topical form. The present study aimed to compare the effects of 1 and 2% pilocarpine mouthwash on xerostomic participants. Methods In this double-blind clinical trial study, 48 subjects with xerostomia were randomly divided into three groups to measure the effects of 1 and 2% pilocarpine and placebo mouthwashes on saliva levels. The amount of saliva in the 1st and 14th days was measured at 0, 45, 60, and 75 mins, while participants used their mouthwash three times a day for 14 days. On the 1st and 14th days, they filled out the information forms on xerostomia and the medicine’s side effects before and after the intervention. Results On the 1st day, the mean salivary flow at 45, 60, and 75 mins in the 2 and 1% pilocarpine mouthwash were significantly higher than in the placebo mouthwash group (p < 0.05). On the 14th day, the mean salivary flow time at 45 mins in the 2% pilocarpine mouthwash group was significantly higher than in the placebo mouthwash group (p = 0.007). Furthermore, the mean salivary flow at 60 and 75 mins in the 2% (p < 0.001) and 1% pilocarpine mouthwash (p = 0.028) was significantly higher than in the placebo group. Moreover, the salivary flow in the 2% pilocarpine mouthwash group was significantly higher than the 1% pilocarpine mouthwash (p < 0.05) during these two times. No side effects were observed in any of the subjects. Conclusions The study showed that 5 ml of 2 and 1% pilocarpine mouthwash for 2 weeks increased salivary flow in xerostomic participants compared to placebo without any side effects.

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P1.91. Assessment of systemic effects of ginger on salivation in patients with post-radiotherapy xerostomia

Cited by 5 publications

References 0 publications

Treatment alternatives for dry mouth: A scoping review

Treatment alternatives for dry mouth: A scoping review

Translation and validation of a French version of the Xerostomia Inventory

Comparison of the 1 and 2% pilocarpine mouthwash in a xerostomic population: a randomized clinical trial

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