2006
DOI: 10.1016/j.yexmp.2005.08.005
|View full text |Cite
|
Sign up to set email alerts
|

p16INK4A expression in cervical premalignant and malignant lesions

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
33
0

Year Published

2007
2007
2014
2014

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 46 publications
(35 citation statements)
references
References 18 publications
2
33
0
Order By: Relevance
“…INK4a immunostaining in at least the basal and parabasal cells increases proportional to the severity of CIN lesions (8)(9)(10)(11). Moreover, CIN1 lesions with p16…”
Section: Introductionmentioning
confidence: 99%
“…INK4a immunostaining in at least the basal and parabasal cells increases proportional to the severity of CIN lesions (8)(9)(10)(11). Moreover, CIN1 lesions with p16…”
Section: Introductionmentioning
confidence: 99%
“…The p16 ink4a overexpression is an indicator of aberrant expression of viral oncogenes and HPV-induced transformation of epithelial cells [10]. Several research groups (including us) have demonstrated by immunohistochemical technique a manifold increase of the p16 ink4a expression in cervical dysplasia and carcinomas in comparison with that in normal epithelium [16][17][18][19] There is an abundant evidence demonstrating that immunohisto-/cytochemical detection of the protein p16 ink4a is a promising test for revealing the HPV-infected cells with malignant potential [ [10,20], for review see [21]]. Thus, the detection of the protein p16 ink4a overexpression is especially useful for early diagnostics of HR-HPV-associated cervical cancer.…”
Section: Introductionmentioning
confidence: 99%
“…Also, serial sections were stained with p16 INK4a , a surrogate marker for human papillomavirus (HPV) [7,8,9,10,11,12]. When necessary, CD10 as indication of endometrial stromal origin was used [13,14].…”
Section: Methodsmentioning
confidence: 99%