P2‐356: Sense of Location in People with Alzheimer's Disease

Pai, Ming‐Chyi; Jan, Shau-Shiun; Tsao, Shu-Hua

doi:10.1016/j.jalz.2016.06.1567

Cited by 2 publications

(4 citation statements)

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“…Regarding linear deviation as a reference for diagnostic power, a deviation of 16 m was set as cutoff for comparison (Pai et al, 2016 ). The hit rates were 0.86, 0.54, and 0.05 for CU, prAD, and AD, respectively ( p < 0.001, post hoc comparisons AD vs. prAD, p < 0.001; AD vs. CU, p < 0.001; prAD vs. CU, p < 0.01; Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…The length of the path was 660 m, on which five sites (A–E) were carefully chosen to prevent individuals from seeing the starting point. The participants, prior to the experiment, were instructed to approach the five target sites one after another and touch the screen of a tablet personal computer (PC) with an innovatively designed Pai-Jan (PJ) device (Pai et al, 2016 ) upon judging that they had reached the target. Figure 1A provides an aerial photo of the campus and the PJ device interface on which the designed path and the location of the target sites were shown.…”

Section: Methodsmentioning

confidence: 99%

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Have I Been Here? Sense of Location in People With Alzheimer's Disease

Pai

Jan

2020

Front. Aging Neurosci.

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Background: When navigating in a particular space, a sense of being at a current location is of great help for the navigators in reaching their destination or getting back to the start. To accomplish this work, interwoven neural structures and neurons are called into play. This system is called the heading direction cell-place cell-grid cell circuit. Evidence from various neuroscience studies has revealed that the regions responsible for this circuit are damaged in the early stages of Alzheimer's disease (AD). This may explain why wayfinding difficulty is one of the most frequent symptoms in persons with AD. The aim of this study was to examine the sense of location (SoL) in persons with mild AD, persons with prodromal AD (prAD), and those who were cognitively unimpaired (CU).Methods: We invited people with mild AD, prAD, and CU to participate in this study. The venue of the core experiment to assess SoL was a 660-m path located on the university campus. The participants were instructed to take a walk on the path and press a device to indicate their arrival at each of the five carefully chosen targets. The linear deviations from the target site were compared among the groups.Results: A total of 20 AD, 28 prAD, and 29 CU persons completed the study. Their Mini-Mental State Examination scores were on average 20 (SD 3), 24 (SD 3), and 28 (SD 2). The groups were well differentiated regarding several measurements for cognitive ability and spatial navigation. As for the SoL, the hit rates of exact location with linear deviation of 16 m or less were 0.05, 0.54, and 0.86 for AD, prAD, and CU persons, respectively. The hit rates were well correlated with the presence of getting lost. Also, SoL differentiated well among CU, PrAD, and AD in terms of average linear deviation.Conclusions: Our employing linear deviation by utilizing a grid-cell function device as an assessment for SoL showed distinct features among the three groups. This model can be used to develop more delicate devices or instruments to detect, monitor, and aid spatial navigation in persons with prAD and AD.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Have I Been Here? Sense of Location in People With Alzheimer's Disease

Pai

Jan

2020

Front. Aging Neurosci.

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“…We have previously shown that individuals with SCD, MCI, and dementia report spatial navigation complaints on SSNCQ-s more frequently than CN older adults [33]. Other studies have shown that QuENA can identify individuals with AD dementia who experience episodes of getting lost [34] and that QuENA-i in particular can predict the occurrence of these episodes over a three-year period [35]. The present study was the rst to comprehensively evaluate the potential of several self-and informant-reported spatial navigation questionnaires (i.e., SSNCQ, SBSOD, and QuENA) to discriminate between CN older adults and participants from the memory clinic cohort, including individuals with SCD, aMCI, and mild dementia de ned by clinical criteria and strati ed by biomarkers.…”

Section: Discussionmentioning

confidence: 96%

“…This is supported by the results of previous studies showing that self-reported spatial navigation de cits are related to AD pathology in cognitively normal older adults as measured by levels of amyloid-β in CSF [27,32] and are common in memory clinic cohorts, including individuals with SCD, aMCI and AD dementia [33]. Both self-and informant-reported spatial navigation questionnaires have been shown to identify individuals with AD dementia with episodes of getting lost [34], but only informant-reported questionnaires predicted getting lost episodes over a three-year period [35]. It is worth noting that self-reported spatial navigation abilities may be in uenced by anxiety and depressive symptoms [33,36].…”

Section: Introductionmentioning

confidence: 99%

Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease

Laczó,

Svatkova,

Lerch

et al. 2023

Preprint

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Background: Impaired spatial navigation is an early marker of Alzheimer's disease (AD), but the utility of reported navigation abilities is poorly understood. We examined the ability of self- and informant-reported spatial navigation questionnaires to discriminate between clinically and AD biomarker-defined participants from the Czech Brain Aging Study (CBAS). The associations of the questionnaires with objective measures of spatial navigation, atrophy of AD-related brain regions, AD biomarker abnormalities, and biomarker status were also examined. Methods: In total, we recruited 262 CBAS participants, including 41 cognitively normal (CN) older adults and 221 participants from the memory clinic cohort with subjective cognitive decline (SCD, n=76), amnestic mild cognitive impairment (aMCI, n=117), and mild dementia (n=28). Participants and their informants completed three spatial navigation questionnaires. Cognitive functions, spatial navigation using real-space and computerized versions of a human analog of the Morris Water Maze, and MRI-derived volume or thickness of six AD-related brain regions were assessed. Biomarker assessment, including measurement of amyloid-β1-42, p-tau181, and total tau in cerebrospinal fluid or dual-phase amyloid PET imaging or both, was performed in a subset of the memory clinic cohort (n=137) to stratify participants by amyloid-β and AT(N) status. Results: Informant-reported spatial navigation questionnaires distinguished participants with aMCI and mild dementia from CN participants, and amyloid-β positive aMCI participants from amyloid-β negative aMCI and CN participants. In contrast, informant-reported spatial navigation abilities were similar in amyloid-β negative aMCI and CN participants. Among participants in the memory clinic cohort (i.e., SCD, aMCI and mild dementia), informant-reported poorer spatial navigation abilities were associated with less accurate performance on real-space and computerized spatial navigation tasks, greater atrophy of the posterior hippocampus and the posteromedial entorhinal cortex, greater AD biomarker abnormalities, and amyloid-β positive status. Self-reported spatial navigation abilities were similar across all participant groups and were not associated with atrophy of AD-related brain regions, AD biomarker abnormalities, or biomarker status. Next, self—reported spatial navigation abilities were only weakly associated with objective measures of spatial navigation. Conclusions: Informant-reported spatial navigation questionnaires may be a useful screening tool for early AD in clinical settings, reflecting atrophy of AD-related brain regions and AD pathology.

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P2‐356: Sense of Location in People with Alzheimer's Disease

Cited by 2 publications

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Have I Been Here? Sense of Location in People With Alzheimer's Disease

Have I Been Here? Sense of Location in People With Alzheimer's Disease

Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease

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