Results: The data show that levels of total and individual phospholipids (except for phosphatidylinositol), as well as those of the preand post-synaptic proteins Synapsin-1 and PSD-95, were significantly enhanced by combined supplementation of FO plus uridine and AOX and not enhanced by supplementation of FO plus uridine without AOX. Brain and plasma DHA, EPA and total omega-3 fatty acids increased while arachidonic acid (AA) and total omega-6 fatty acids were decreased in rats receiving the FO plus uridine. Conclusions: Our data suggest that the antioxidants, vitamin C, vitamin E and selenium, in a diet containing phospholipid precursors are essential for the precursors' effects on increasing levels of membrane phospholipids and synaptic proteins, the indirect indicators of synaptogenesis.
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