P213 A comparison of ventilation MRI using hyperpolarised 3He and 129Xe to assess cystic fibrosis lung disease

Is hyperpolarised gas magnetic resonance imaging a valid and reliable tool to detect lung health in cystic fibrosis patients? a cosmin systematic review

“…The 25 included studies were published between 2005 and 2020. Six were conducted in the USA [8,24,28,29,36,40], seven in Canada [18,20,23,31,32,37,38], 10 in the UK [19,25,26,30,[33][34][35]43,45,46], one in France [22], and one in Ireland [4]. Eighteen of the studies investigated HP 3 He MRI [4,8,[18][19][20]22,23,[28][29][30][31][32][33][34][35]40,43,45] six investigated HP 129 Xe MRI [24,25,[36][37]…”

“…Two case series exposed participants to interventions such as nebulisers and chest physiotherapy prior to the MRI scan to understand treatment response [18,29]. One study presented a nested case series within a larger cross-sectional study [26]. There was one crossover clinical trial [40], There was one pilot study [20], one retrospective analysis study [24], and one cohort study [38].…”

“…Eight studies assessed test-retest reliability [8,19,20,[22][23][24][25][26]; five using the ICC [8,20,22,24,25], four using Bland-Altman tests [8,19,25,26], and one using ANOVA [23] (Table 4). There was good evidence for the test-retest reliability of MRI in assessing VDP across three studies of very good [25] and adequate quality [20,22] in which the intraclass correlations were more than 0.9 (Table 4).…”

“…Seven studies using HP 3 He MRI assessed construct validity [4,8,18,22,40,43,45], in addition to one study which used both HP 3 He and 129 Xe [26] (Table 7). Four of the eight studies did not report a study hypothesis and were rated indeterminate [22,26,43,45] (Appendix 2).…”

“…Seven studies using HP 3 He MRI assessed construct validity [4,8,18,22,40,43,45], in addition to one study which used both HP 3 He and 129 Xe [26] (Table 7). Four of the eight studies did not report a study hypothesis and were rated indeterminate [22,26,43,45] (Appendix 2). From the four studies which included a hypothesis, two studies of very good quality [4,40] found a strong correlation between FEV1 and VDP a weaker correlation (= -0.68) [18].…”