P2507Long-term effects of fine particulate matter on cardiovascular disease and mortality

Kim, Ha Yong; Kim, Jihyeung; Kim, S.; Kim, H.; Heo, Ji Hoe; Yi, Sang-Heon; Kim, K.; Youn, Tae Jin; Chae, In‐Ho; Kang, Sung-Bum

doi:10.1093/eurheartj/ehx502.p2507

Cited by 1 publication

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“…Baseline hemodynamic severity correlated with distance to main road and the length of road surrounding the residential addresses for both the crude ( Figure S5) and the further-adjusted ( Increased air pollution exposure has been documented as an independent risk factor for mortality and hospitalisations in the general population [2,3], and in several chronic health conditions [4][5][6][7][8][9]15]. Evidence suggests that these effects are stronger for cardiovascular mortality than for other causes of mortality [25,26].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, PM 2.5 emissions have been consistently found to have more detrimental health effects compared to gaseous emissions (e.g. NO 2 ), with cardiovascular events exhibiting the strongest association with exposure to PM 2.5 [13,15]. Particles generated by diesel exhaust are considered particularly toxic since they carry a much larger fraction of toxic compounds [10,27].…”

Section: Resultsmentioning

confidence: 99%

“…The present study has several limitations that should be acknowledged. Since evidence suggests that mean PM 2.5 and NO 2 concentrations minimally fluctuate over the years [15], we estimated individual exposure to air pollution using the 2010 annual average air pollution maps of ambient PM 2.5 and NO 2 concentrations. W stations.…”

Section: Resultsmentioning

confidence: 99%

“…5 increases the risk of cardiovascular death [2,13], although long-term effects of PM 2.5 appear to have a greater impact on cardiovascular mortality [10,14]. Amongst cardiovascular events, the occurrence of heart failure exhibited the strongest association with PM 2.5 exposure [13,15].…”

Section: Introductionmentioning

confidence: 99%

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Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis

et al. 2019

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While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter with a 50% cut-off aerodynamic diameter ≤2.5 μm (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK National Cohort Study of Idiopathic and Heritable PAH. Associations with transplant-free survival and pulmonary haemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (unadjusted hazard ratio (HR) 2.68 (95% CI 1.11–6.47) per 3 μg·m−3; p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38 (95% CI 1.44–13.36) per 3 μg·m−3; p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival. Conversely, indirect measures of exposure to traffic-related air pollution within the 500–1000 m buffer zones correlated with the European Society of Cardiology/European Respiratory Society risk categories as well as pulmonary haemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.

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