P27. Altered regional and interregional interrelations of glutamate and GABA in patients with chronic low back pain – A 1H-MR spectroscopic study

Local and Interregional Neurochemical Associations Measured by Magnetic Resonance Spectroscopy for Studying Brain Functions and Psychiatric Disorders

“…In patients with subclinical hepatic encephalopathy the occipital lobe phosphodiester measured by 31 P MRS and Glx levels were found to be negatively correlated (13). Interregional correlations of glutamate and GABA levels have also been reported in many studies [e.g., (8,(14)(15)(16)(17)]. These studies have clearly demonstrated that neurochemical associations are abnormally altered in many brain disorders, but the absolute strengths of these correlations measured by different MRS methodologies have been inconsistent or controversial [e.g., (5,14,15,(18)(19)(20)(21)(22)(23)].…”

“…Many significant correlations among neurometabolites and between individual neurometabolites and non-MRS measures of brain function and disorders have been reported more recently. Altered correlations have been found in neuropsychiatric disorders, revealing abnormal neurochemical associations under pathophysiological conditions [e.g., (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)]. The strong correlations among Nacetylaspartate (NAA)/choline in precentral gyrus, midcingulate cortex, and thalamus found in healthy subjects were absent in patients with amyotrophic lateral sclerosis (4).…”

Neurochemical correlations in short echo time proton magnetic resonance spectroscopy

“…Subsequently, statistical analysis based on, for example, multivariate linear regression models is performed to correlate metabolite concentrations measured by short‐TE MRS with clinical parameters such as genetic abnormalities, symptoms, and/or response to treatment. In addition, many studies have also evaluated cross‐correlation coefficients between metabolite concentrations and found altered neurochemical correlations in aging and brain disorders 2,3 …”