P2Y
            <sub>2</sub>
            deficiency impacts adult neurogenesis and related forebrain functions

Ali, Amira A. H.; Abdel-Hafiz, Laila; Tundo-Lavalle, Federica; Hassan, Soha A; Gall, Charlotte von

doi:10.1096/fj.202002419rr

Cited by 10 publications

(3 citation statements)

References 97 publications

(197 reference statements)

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“…Thus, purine and pyrimidine-analogues could modulate fast and long-lasting effects of temporo-ammonic transmission via these receptors. This is consistent with our earlier study showing a role of P2Y 2 in p -Akt expression and spatial working memory [ 51 ]. Moreover, ATP analogs biphasically modulate evoked glutamate release from rat hippocampal nerve terminals, the facilitation being mediated by P2X1, P2X2, and P2X3, and the inhibition by P2Y 1 , P2Y 2 , and or P2Y 4 [ 45 ].…”

Section: Discussionsupporting

confidence: 94%

“…In both the hippocampus and the SCN, the phases of rhythmic extracellular ATP levels [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , ...…”

Section: Discussionunclassified

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Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus

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Harr

et al. 2021

IJMS

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ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and pathophysiological processes. P2X receptors are ligand-gated ion channels mediating excitatory postsynaptic responses whereas P2Y receptors are G protein-coupled receptors mediating slow synaptic transmission. A variety of P2X and P2Y subtypes with distinct neuroanatomical localization provide the basis for a high diversity in their function. There is increasing evidence that P2 receptor signaling plays a prominent role in learning and memory and thus, in hippocampal neuronal plasticity. Learning and memory are time-of-day-dependent. Moreover, extracellular ATP shows a diurnal rhythm in rodents. However, it is not known whether P2 receptors have a temporal variation in the hippocampus. This study provides a detailed systematic analysis on spatial and temporal distribution of P2 in the mouse hippocampus. We found distinct spatial and temporal distribution patterns of the P2 receptors in different hippocampal layers. The temporal distribution of P2 receptors can be segregated into two large time domains, the early to mid-day and the mid to late night. This study provides an important basis for understanding dynamic P2 purinergic signaling in the hippocampal glia/neuronal network.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionunclassified

Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus

Lommen

Detken

Harr

et al. 2021

IJMS

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show abstract

“…The precise mechanisms through which P2Y12R-mediated effects act on the developing neuronal networks and adult cytoarchitecture should be investigated in further studies. Our observations are also supported by earlier studies that have implicated purinergic signaling in regulation of neurogenesis, although these results were mainly restricted to adult neurogenesis in the dentate gyrus and olfactory bulb (Ali et al, 2021;Stefani et al, 2018). Such mechanisms could also be important for development of complex pathological states such as seizure-induced adult neurogenesis (Mo et al, 2019).…”

Section: Discussionsupporting

confidence: 90%